Feeder Layer Cells Actions and Applications|
Regenerative medicine has been gaining importance in recent years as a discipline that moves biomedical technology from the laboratory to the patients. Human stem and pluripotent cells play an important role, but feeder cells presence is necessary for these progenitor cells to grow and differentiate. The authors address recent specific applications including those associated to the growth of embryonic and induced pluripotent stem cells. [Tissue Eng Part B Rev] Abstract
Transcription Factor-Mediated Reprogramming: Epigenetics and Therapeutic Potential
The authors focus on the different ways of implementing transcription factor-mediated reprogramming, their associated epigenetic changes and its therapeutic potential. [Immunol Cell Biol] Abstract
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Three USC Researchers Win $4.3 Million in Awards from California’s Stem Cell Agency|
Three scientists from Keck Medicine of USC have won grants exceeding $4.3 million from the California Institute for Regenerative Medicine for research that includes creating a temporary liver for patients, finding novel ways to treat immune disorders and blood diseases, and developing new animal models for heart failure, diabetes and neurodegenerative diseases. [University of Southern California] Press Release
Juno Therapeutics Establishes Manufacturing Presence in Washington State
Juno Therapeutics, Inc. announced that it has entered into a lease agreement for a facility in Bothell, Washington to manufacture the company’s cell therapy products. The facility, which is expected to come online in early 2016, will support Juno’s planned JCAR015 multicenter clinical trial, additional clinical programs in Juno’s pipeline, and the company’s first commercial products. [Juno Therapeutics, Inc.] Press Release
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Moot Punishments for Japanese STAP Scientists|
Four Japanese stem-cell researchers have been disciplined for their role in the scandal that gripped Japan — and the international science community — last year. The harshest punishments, however, went to two researchers who have since left their jobs. [Nature News] Editorial
NIH Proposal to Create Grant for Aging Scientists Hits a Nerve
A seemingly innocuous idea from the National Institutes of Health (NIH) for nudging aging scientists to retire is being blasted in the blogosphere. NIH’s proposal — an “emeritus” award that senior scientists would use to pass their work on to younger colleagues and wind down their labs — is unnecessary and could take funding away from younger and midcareer scientists, many commenters argued. [ScienceInsider] Editorial