Volume 10.37 | Sep 30

ESC & iPSC News 10.37 September 30, 2015
ESC & iPSC News
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Regulation of Nucleosome Architecture and Factor Binding Revealed by Nuclease Footprinting of the ESC Genome
By simultaneously quantifying alterations in small MNase footprints over the binding sites of 30 regulatory factors in mouse embryonic stem cells (ESCs), scientists provided evidence that esBAF and Mbd3/NuRD modulate the binding of several regulatory proteins. [Cell Rep] Full Article | Graphical Abstract
Weekend-Free Culture hPSCs with mTeSR™1 or TeSR™-E8™
PUBLICATIONS (Ranked by impact factor of the journal)
Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem Cells
Researchers report the direct repression of core pluripotency factors by Tgif1, a previously known terminal repressor of TGFβ/activin/nodal signaling. [Cell Rep] Full Article | Graphical Abstract

The Knockdown of H19lncRNA Reveals Its Regulatory Role in Pluripotency and Tumorigenesis of Human Embryonic Carcinoma Cells
To study the role of H19 in oncogenesis and pluripotency, investigators down-regulated H19 expression in vitro and in vivo in pluripotent human embryonic carcinoma and embryonic stem cells. [Oncotarget] Full Article

Cdh2 Stabilizes FGFR1 and Contributes to Primed-State Pluripotency in Mouse Epiblast Stem Cells
To understand the function of cadherin 2 (Cdh2) in mouse epiblast stem cells (mEpiESCs), researchers compared the expression of pluripotency-related genes in mEpiSCs and mouse embryonic stem cells after either Cdh2 knockdown or Cdh2 over-expression. [Sci Rep] Full Article

OCT4 Coordinates with WNT Signaling to Pre-Pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm
Investigators demonstrated that the pluripotency gene OCT4 has a role in regulating differentiation via Wnt signaling. OCT4 expression levels in human embryonic stem (ES) cells increased transiently during the first 24 hours of in vitro differentiation, with OCT4 occupancy increasing at endoderm regulators such as SOX17 and FOXA2. [Stem Cell Reports] Full Article

Cyclin E1 Plays a Key Role in Balancing between Totipotency and Differentiation in Human Embryonic Cells
The authors investigated if Cyclin E1 plays a role in human embryogenesis, in particular during the early developmental stages characterized by a short cell cycle. [Mol Hum Reprod] Abstract

Transcriptome Characteristics and X-Chromosome Inactivation Status in Cultured Rat Pluripotent Stem Cells
Scientists showed that reprogramming of rat somatic cells to a pluripotent state was accompanied by X-chromosome reactivation. [Stem Cells Dev] Abstract

Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells
The authors found that exposure to microgravity for 15 days inhibits mouse embryonic stem cell differentiation and expression of terminal germ layer lineage markers in embryoid bodies. [Stem Cells Dev] Abstract

Embryonic Stem Cell Growth Factors Regulate eIF2α Phosphorylation
The authors found abundant phosphorylated-eIF2α (P-eIF2α) in both pluripotent mouse and human embryonic stem cells (ESCs), but little P-eIF2α in ESCs triggered to differentiate. [PLoS One] Full Article

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Hallmarks of Pluripotency
The authors describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance. [Nature] Full Article

Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field.
New York Blood Center Announces New Collaboration to Foster Groundbreaking Advancements in Regenerative Medicine
New York Blood Center and the Howard and Abby Milstein Foundation announced a further expansion of their collaborative efforts to advance the use of specialized stem cell lines in regenerative medicine. [New York Blood Center] Press Release

$25 Million for UQ Genomics Research
A $25 million boost to genomics research at Queensland research institutions will help experts in their efforts to improve healthcare. The State Government announced new funding for genomics research at The University of Queensland (UQ). [The University of Queensland] Press Release

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New U.S. Board Proposed to Tackle Regulatory Burden on Research Universities
The best way to ease the regulatory burden on U.S. academic researchers is to create another layer of bureaucracy. That surprising conclusion is the top recommendation in a report by a National Academies committee that Congress asked to examine the current regulatory jungle confronting universities that receive federal research dollars. [ScienceInsider] Editorial

Cardiologist to Head Extramural Research at NIH
A cardiovascular epidemiologist and research administrator is taking the helm of the office that oversees policies for the National Institutes of Health’s (NIH’s) $25 billion a year in research grants and contracts. Michael Lauer, who has been with the National Heart, Lung, and Blood Institute since 2007, will become NIH deputy director for extramural research in a few weeks. [ScienceInsider] Editorial
NEW Clinical Applications of Stem Cells
February 24, 2015
Singapore, Singapore

Visit our events page to see a complete list of events in the ESC & iPSC community.
NEW Assistant/Associate/Full Professor – Biomedical Engineering (Worcester Polytechnic Institute)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Fellow – Cancer Genetics (Wellcome Trust Sanger Institute)

Senior Stem Cell Scientist (Medicines and Healthcare products Regulatory Agency)

Postdoctoral Researcher – Epigenetic Modifiers (Van Andel Research Institute)

Postdoctoral Position – Spinal Cord Injury Research (Indiana University-Purdue University)

Postdoctoral Fellowship – Embryonic Stem Cells, Bio-NEMS, and Tissue Engineering (University of South Carolina)

Laboratory Head – Stem Cell Biology (RIKEN)

Postdoctoral Research Fellow – Development and Pathogenesis of Pancreatic Cancer (University College London)

Postdoctoral Fellow – (Johns Hopkins University School of Medicine)

Advanced Research Assistant – Gene Targeting (Wellcome Trust Sanger Institute)

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