Volume 10.42 | Nov 4

ESC & iPSC News 10.42 November 4, 2015
ESC & iPSC News
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Researchers Track Gene That Keeps Stem Cells in Check
When it comes to stem cells too much of a good thing isn’t wonderful: Producing too many new stem cells may lead to cancer; producing too few inhibits the repair and maintenance of the body. Researchers describe a key gene that maintains this critical balance. Called Prkci, the gene influences whether stem cells self-renew to produce more stem cells or differentiate into more specialized cell types, such as blood or nerves. [Press release from the University of Southern California discussing online publication in Stem Cell Reports]
Press Release | Full Article | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Coordination of m6A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming
Scientists showed that the chromatin-associated zinc finger protein 217 (ZFP217) coordinates epigenetic and epitranscriptomic regulation. ZFP217 interacted with several epigenetic regulators, activated the transcription of key pluripotency genes, and modulated N6-methyladenosine (m6A) deposition on their transcripts by sequestering the enzyme m6A methyltransferase-like 3. [Cell Stem Cell]
Abstract | Graphical Abstract | Press Release

Histone Demethylase Expression Enhances Human Somatic Cell Nuclear Transfer Efficiency and Promotes Derivation of Pluripotent Stem Cells
Investigators showed that overexpression of a related histone H3 lysine 9 trimethylation (H3K9me3) demethylase KDM4A improves human somatic cell nuclear transfer (SCNT), and that, as in mice, H3K9me3 in the human somatic cell genome is an SCNT reprogramming barrier. [Cell Stem Cell]
Abstract | Graphical Abstract

Efficient Delivery of Nuclease Proteins for Genome Editing in Human Stem Cells and Primary Cells
The authors describe procedures for implementing protein-based genome editing in human embryonic stem cells and primary cells. [Nat Protoc] Abstract

TRIM28 Controls Genomic Imprinting through Distinct Mechanisms during and after Early Genome-wide Reprogramming
By analyzing maternal, zygotic, maternal-zygotic, and conditional Trim28 mutants, researchers found that the transcription factor TRIM28 controls genomic imprinting through distinct mechanisms at different developmental stages. During early genome-wide reprogramming, both maternal and zygotic TRIM28 are required for the maintenance of methylation at germline imprints. [Cell Rep] Full Article | Graphical Abstract

Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells
Researchers showed that the efficiency and kinetics of induced pluripotent stem cells reprogramming are dramatically improved by the combined expression of Jarid2 and genes encoding its associated proteins. [Stem Cells] Abstract

Stimulation of Vasculogenesis and Leukopoiesis of Embryonic Stem Cells by Extracellular Transfer RNA and Ribosomal RNA
Scientists investigated the impact of extracellular ribonucleic acid, especially transfer RNA, on vasculogenesis and leukopoiesis of mouse embryonic stem cells [Free Radic Biol Med] Full Article

Adrenergic DNA Damage of Embryonic Pluripotent Cells via β2 Receptor Signaling
Researchers revealed that adrenergic stress mediators cause DNA damage of embryonic pluripotent cells through the β2 adrenergic receptor/adenylate cyclase/cAMP/PKA signaling pathway. The adrenergic stress agonists adrenaline, noradrenaline, and isoprenaline caused DNA damage and apoptosis of embryonic stem cells and embryonal carcinoma stem cells. [Sci Rep] Full Article

Three-Dimensional Bioprinting of Embryonic Stem Cells Directs Highly Uniform Embryoid Body Formation
Extrusion-based 3D bioprinting technology was utilized for biofabricating embryonic stem cells into a three-dimensional cell-laden construct. [Biofabrication] Full Article | Press Release

Rapidly Generating Knockout Mice from H19-Igf2 Engineered Androgenetic Haploid Embryonic Stem Cells
Investigators report the high-frequency generation of healthy, fertile mice from H19-Igf2 imprinting-locus modified androgenetic haploid embryonic stem cells, which maintained normal paternal imprinting and pluripotency. [Cell Disc] Full Article

Free Wallchart from Nature Reviews Neuroscience on Modeling Neurological Disease with iPS Cells
Clinical Trials in a Dish: The Potential of Pluripotent Stem Cells to Develop Therapies for Neurodegenerative Diseases
The authors explore the potential and caveats of induced pluripotent stem cell (iPSC) technology as a platform for drug development and screening, and the future potential to use large cohorts of disease-bearing iPSCs to perform clinical trials in a dish. [Annu Rev Pharmacol Toxicol] Abstract

Transdifferentiation via Transcription Factors or microRNAs: Current Status and Perspective
Transdifferentiation as a new approach for obtaining the ideal cells for transplantation has gradually become a hot research topic. Compared with the induced pluripotent stem cells technique, transdifferentiation may have better efficiency and safety. [Differentiation] Abstract

Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field.
Georgia State Adds Two Research Centers in Healthy Development, Molecular and Translational Medicine
Georgia State University has created two new research centers—the Mark Chaffin Center for Healthy Development and the Center for Molecular and Translational Medicine—dedicated to health and medicine. [Georgia State University] Press Release

RegMedNet showcases KCL’s Centre for Stem Cells and Regenerative Medicine
For the next five weeks, RegMedNet will offer an exclusive spotlight on the aims and expertise of King’s College London’s (KCL’s) Centre for Stem Cells and Regenerative Medicine. RegMedNet, a leading online community for regenerative medicine professionals, is a free portal managed by Future Science Group. [RegMedNet (EurekAlert!)] Press Release

Two A*STAR Scientists Clinch Prestigious 2015 EMBO Young Investigator Awards
Two A*STAR scientists have joined 21 other scientists as EMBO Young Investigators. They are: Dr Khor Chiea Chuen, Group Leader at the Genome Institute of Singapore, and Dr Nicolas Plachta, Senior Principal Investigator at the Institute of Molecular and Cell Biology, [Agency for Science, Technology and Research] Press Release

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NIH Refocuses Research into Chronic Fatigue Syndrome
In the wake of mounting criticism that researchers pay scant attention to myalgic encephalomyelitis/chronic fatigue syndrome, the U.S. National Institutes of Health (NIH) announced that it is increasing efforts to figure out what causes the baffling illness and to find treatments for it. [ScienceInsider] Editorial

Neuroscientist Tapped as Australia’s Chief Scientist
Neuroscientist Alan Finkel will be Australia’s next chief scientist, Prime Minister Malcolm Turnbull announced at a press conference in Canberra. [ScienceInsider] Editorial
NEW Hematopoietic Stem Cells: From the Embryo to the Aging Organism
June 3-5, 2016
Heidelberg, Germany

Visit our events page to see a complete list of events in the ESC & iPSC community.
NEW Postdoctoral Fellow – Cardiac Regeneration (Duke University)

NEW Postdoctoral Position – Modeling and Treatment of Human Skeletal Muscle Diseases (Duke University)

Team Leader Position – Developmental Biology (Institut de Biologie Paris-Seine)

Postdoctoral Position – Neuroscience/Stem Cell Research (University of California, Davis)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Fellow – iPSC Research (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Biomaterials for Cell Reprogramming (Institute of Tissue Regeneration Engineering)

Postdoctoral Position – Stem Cells, Development, and Cancer Biology (University of California, Santa Cruz)

Assistant/Associate/Full Professor – Biomedical Engineering (Worcester Polytechnic Institute)

Assistant Professor – Stem Cell Biology (University of South Carolina)

Postdoctoral Position – Spinal Cord Injury Research (Indiana University-Purdue University)

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