Volume 10.43 | Nov 18

ESC & iPSC News 10.43 November 18, 2015
ESC & iPSC News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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New Stem Cell Gene Correction Process Puts Time on Researchers’ Side
Researchers have devised a way to dramatically cut the time involved in reprogramming and genetically correcting stem cells, an important step to making future therapies possible. They demonstrated how genetically repaired stem cells can be derived from patient skin cells in as little as two weeks, compared to conventional multi-step approaches that take more than three months. [Press release from Murdoch Childrens Research Institute discussing online publication in Stem Cell Reports] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming
Researchers showed that the frequency of mitochondrial flashes (mitoflashes) transiently increases, accompanied by flash amplitude reduction, during the early stages of reprogramming. [Cell Metab]
Abstract | Graphical Abstract

Generation of Functional Hippocampal Neurons from Self-Organizing Human Embryonic Stem Cell-Derived Dorsomedial Telencephalic Tissue
The authors showed the generation of functional hippocampal granule- and pyramidal-like neurons from self-organizing dorsomedial telencephalic tissue using human embryonic stem cells. [Nat Commun] Full Article

Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation
Scientists showed that Bax−/−Bak−/− murine embryonic stem cells display defects during the exit from pluripotency, both in culture and during teratoma formation. [Curr Biol] Abstract | Graphical Abstract

Generation of an Expandable Intermediate Mesoderm Restricted Progenitor Cell Line from Human Pluripotent Stem Cells
Scientists used a cellular microarray technology to identify a defined and optimized culture condition that supports the derivation and propagation of a cell population with mesodermal properties. [eLife]
Full Article | Press Release

Cellular Heterogeneity in the Level of mtDNA Heteroplasmy in Mouse Embryonic Stem Cells
Scientists analyzed cellular heterogeneity in embryonic stem cells derived from a polymorphic mouse model containing NZB and BALB mtDNA genotypes. [Cell Rep] Full Article | Graphical Abstract

Improvement in Mouse iPSC Induction by Rab32 Reveals the Importance of Lipid Metabolism during Reprogramming
By testing the efficiency of induced pluripotent stem cell (iPSC) generation using Oct4, Sox2, Klf4 plus one additional gene, investigators found that Rab32 improved reprogramming efficiency. [Sci Rep] Full Article

Dzip3 Regulates Developmental Genes in Mouse Embryonic Stem Cells by Reorganizing 3D Chromatin Conformation
The authors tested whether known H2A ubiquitin ligases and deubiquitylases are involved in mouse embryonic stem cell regulation and discovered that Dzip3, the E3 ligase of H2AK119, represses differentiation-inducible genes, as does Ring1B. [Sci Rep] Full Article

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells
Investigators generated pyruvate kinase deficiency (PKD) induced pluripotent stem cells from peripheral blood mononuclear cells of PKD patients by non-integrative Sendai viral vectors. [Stem Cell Reports] Full Article

Selective Targeting of the BRG/PB1 Bromodomains Impairs Embryonic and Trophoblast Stem Cell Maintenance
The authors showed that exposure of embryonic stem cells to PFI-3 led to deprivation of stemness and deregulated lineage specification. [Sci Adv] Full Article

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Chromatin Remodeling and Bivalent Histone Modifications in Embryonic Stem Cells
The authors discuss bivalency in general, describe the machineries that catalyze bivalent chromatin domains, and portray the emerging connection between bivalency and the action of different families of chromatin remodelers, namely INO80, esBAF, and NuRD, in pluripotent cells. [EMBO Rep] Abstract

Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field.
ViaCyte Licenses Cell Differentiation Technology to Takara Bio Inc.
ViaCyte, Inc. announced that the company has entered into a non-exclusive licensing agreement with Takara Bio, Inc. Takara will utilize certain portions of ViaCyte’s cell differentiation technology to expand its stem cell product line, marketed under the Cellartis® brand. [ViaCyte, Inc.] Press Release

Connecticut Bioscience Innovation Fund Approves $1 Million in Funding for Two Healthcare IT Companies
Connecticut Innovations announced that the Connecticut Bioscience Innovation Fund has approved $1 million in funding to support bioscience innovations during the latest review of project applications. [BioInnovation CT.] Press Release

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European Commission Appoints Top Scientists to Fill Policy Advice Gap
Seven scientists have been appointed to provide the European Commission with policy advice—bringing an end to a year of suspense since the awkward exit of Anne Glover, the first and only chief scientific adviser in the commission’s history. [ScienceInsider] Editorial

Data Check: How U.S. Budget Deal Turns $30 Billion into $3 Billion
Get your money this year—because federal spending in 2017 may feel very tight. That message for U.S. scientists is buried in the new two-year budget agreement that President Barack Obama signed. [ScienceInsider] Editorial
NEW Cell Symposia – 10 Years of iPSCs
September 25-27, 2016
Berkeley, United States

Visit our events page to see a complete list of events in the ESC & iPSC community.
NEW Team Leader/Professor/Associate Professor – Regenerative Medicine (Ji Nan University)

NEW Postdoctoral Fellow and Research Scientist – Epigenomics and Systems Biology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Cardiac Regeneration (Duke University)

Postdoctoral Position – Modeling and Treatment of Human Skeletal Muscle Diseases (Duke University)

Team Leader Position – Developmental Biology (Institut de Biologie Paris-Seine)

Postdoctoral Position – Neuroscience/Stem Cell Research (University of California, Davis)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Fellow – iPSC Research (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Biomaterials for Cell Reprogramming (Institute of Tissue Regeneration Engineering)

Assistant/Associate/Full Professor – Biomedical Engineering (Worcester Polytechnic Institute)

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