Pancreatic Differentiation of Pdx1-GFP Reporter Mouse Induced Pluripotent Stem Cells
Researchers generated and characterized induced pluripotent stem cells from Pdx1-GFP transgenic mice. The use of a GFP reporter knocked into the endogenous Pdx1 promoter allowed them to monitor pancreatic induction based on the expression of Pdx1, a pancreatic master transcription factor, and to isolate a pure Pdx1-GFP+ population for downstream applications. [Differentiation] Abstract
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WPI Team Awarded Patent for Reprograming Skin Cells
Cell therapies for a range of serious conditions, including heart attacks, diabetes, and traumatic injuries, will be accelerated by research at Worcester Polytechnic Institute (WPI) that yielded a newly patented method of converting human skin cells into engines of wound healing and tissue regeneration. [Worcester Polytechnic Institute] Press Release
Industry-Backed Project Aims to Become One-Stop Shop for Clinical Research Data
There’s a broad consensus that widely sharing patient-level data from clinical trials is desirable, with potential advantages ranging from faster identification of side effects, easier confirmation of a therapy’s efficacy, and a reduction in duplicative efforts. A new project from Boston’s Brigham and Women’s Hospital and Harvard University is trying to build a global, neutral platform for such data sharing, but some are skeptical it’s the right solution. [ScienceInsider] Editorial