ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

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Quantitative Proteomics Reveals the Dynamic Proteome Landscape of Zebrafish Embryos during the Maternal-to-Zygotic Transition

May 10, 2024

[iScience] The authors revealed the expression dynamics of 5,000 proteins across four stages of zebrafish embryos during maternal-to-zygotic transition (MZT), representing one of the most systematic surveys of proteome landscape of the zebrafish embryos during MZT.

ARTseq-FISH Reveals Position-Dependent Differences in Gene Expression of Micropatterned mESCs

May 9, 2024

[Nature Communications] To identify the effect of cellular position on gene expression, researchers developed a scalable antibody and mRNA targeting sequential fluorescence in situ hybridization method capable of simultaneously profiling mRNAs, proteins, and phosphoproteins in single cells.

Local and Global Changes in Cell Density Induce Reorganization of 3D Packing in a Proliferating Epithelium

May 8, 2024

[Development] Investigators used live imaging of the sea star embryo coupled with deep learning-based segmentation to dissect the relative contributions of cell density, tissue compaction, and cell proliferation on epithelial architecture.

A Novel Protein CYTB-187AA Encoded by the Mitochondrial Gene CYTB Modulates Mammalian Early Development

May 8, 2024

[Cell Metabolism] Researchers demonstrated that cytochrome b (CYTB) also encoded an unrecognized 187-amino-acid-long protein, CYTB-187AA, using the standard genetic code of cytosolic ribosomes rather than the mitochondrial genetic code.

ISWI Chromatin Remodeling Complexes Recruit NSD2 and H3K36me2 in Pericentromeric Heterochromatin

May 8, 2024

[Journal of Cell Biology] Investigators revealed the mechanism of heterochromatin targeting of histone H3 lysine36 dimethylation (H3K36me2). Among several H3K36 methyltransferases, NSD2 was responsible for inducing heterochromatic H3K36me2.

Unraveling the Impact of ZZZ3 on the mTOR/Ribosome Pathway in Human Embryonic Stem Cells Homeostasis

May 8, 2024

[Stem Cell Reports] Scientists investigated the role of zinc finger ZZ-type containing 3 (ZZZ3) in human ESCs homeostasis. They found that knockdown of ZZZ3 negatively impacted ribosome biogenesis, translation, and mTOR signaling, leading to a significant reduction in cell proliferation.

Malat1 Affects Transcription and Splicing through Distinct Pathways in Mouse Embryonic Stem Cells

May 8, 2024

[NAR Genomics and Bioinformatics] Researchers performed a nuclear knockdown of Malat1 in mESCs, causing the de-regulation of 320 genes and aberrant splicing of 90 transcripts, some of which potentially affecting the translated protein sequence.

Forward Programming Human Pluripotent Stem Cells into Microglia

May 8, 2024

[Trends in Cell Biology] Investigators provide a comprehensive assessment of published forward programming protocols that are based on forced expression of key lineage transcription factors.

Scientists Are Trying to Get Cows Pregnant with Synthetic Embryos

May 8, 2024

[MIT Technology Review] The experiment, at the University of Florida, is an attempt to create a large animal starting only from stem cells—no egg, no sperm, and no conception.

The Transcription Factor OCT6 Promotes the Dissolution of the Naïve Pluripotent State by Repressing Nanog and Activating a Formative State Gene Regulatory Network

May 7, 2024

[Scientific Reports] The authors showed that Oct6 was not expressed in mESCs but was rapidly induced as cells exit the naïve pluripotent state.

H1FOO-DD Promotes Efficiency and Uniformity in Reprogramming to Naive Pluripotency

May 7, 2024

[Stem Cell Reports] Researchers showed that expressing the maternal-specific linker histone H1FOO fused to a destabilizing domain (H1FOO-DD), together with OCT4, SOX2, KLF4, and LMYC, in human somatic cells improved the quality of reprogramming to both primed and naive pluripotency.

Monocytes Prevent Apoptosis of iPSCs and Promote Differentiation of Kidney Organoids

May 3, 2024

[Stem Cell Research & Therapy] Differentiation of kidney organoids from human iPSCs was performed. Cell survival and autophagy were analyzed using cell counting kit 8 kit and autophagy detection kit.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.