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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
SRRM2 Splicing Factor Modulates Cell Fate in Early Development
[Biology Open] The authors showed that serine/arginine repetitive matrix 2 (Srrm2) dosage was critical for maintaining ESC pluripotency and cell identity.
Development and Application of Haploid Embryonic Stem Cells
[Stem Cell Research & Therapy] Investigators review the progress of haploid ESC research and briefly discuss the applications of haploid ESCs.
Induced Pluripotent Stem Cells (iPSCs): Molecular Mechanisms of Induction and Applications
[Signal Transduction and Targeted Therapy] The authors outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications.
YY1 Binding Is a Gene-Intrinsic Barrier to Xist-Mediated Gene Silencing
[EMBO Reports] Researchers examined mESC lines with an inducible Xist allele and integrated allele-specific data of gene silencing and decreasing inactive X chromatin accessibility over time courses of Xist induction with cellular differentiation.
Precise Editing of Pathogenic Nucleotide Repeat Expansions in iPSCs Using Paired Prime Editor
[Nucleic Acids Research] Scientists presented a precise and programmable method called prime editor–mediated correction of nucleotide repeat expansion for correcting pathogenic nucleotide repeat expansion.
Maternal Factor Trim75 Contributes to Zygotic Genome Activation Program in Mouse Early Embryos
[Molecular Biology Reports] The authors utilized published single-cell RNA sequencing data from a Dux-mediated mESCs to induce a 2-cell-like transition state and selected potential drivers for the transition according to an RNA velocity analysis.
Analysis of Long-Range Chromatin Contacts, Compartments and Looping between Mouse Embryonic Stem Cells, Lens Epithelium, and Lens Fibers
[Epigenetics & Chromatin] Chromatin organization between mESCs, newborn lens epithelium, and fiber cells were analyzed using Hi-C. Localization of CTCF in both lens chromatins was determined by ChIP-seq and compared with ESCs.
Murine and Human-Purified very Small Embryonic-like Stem Cells (VSELs) Express Purinergic Receptors and Migrate to Extracellular ATP Gradient
[Stem Cell Reviews And Reports] Researchers reported that human umbilical cord blood and murine bone marrow purified VSELs expressed mRNA for P1 and P2 purinergic receptors and CD39 and CD73 ectonucleotidases converting extracellular ATP into its signaling metabolite extracellular adenosine.
Detection of Newly Synthesized RNA Reveals Transcriptional Reprogramming during ZGA and a Role of Obox3 in Totipotency Acquisition
[Cell Reports] The authors developed a method to capture and sequence newly synthesized RNA in early mouse embryos, providing a view of transcriptional reprogramming during zygotic genome activation.
Phototoxicity Avoidance Is a Potential Therapeutic Approach for Retinal Dystrophy Caused by EYS Dysfunction
[JCI Insight] Scientists generated retinal organoids from iPSCs derived from patients with eyes shut homolog (EYS)-associated retinal dystrophy.
Chromatin Landscape Instructs Precise Transcription Factor Regulome during Embryonic Lineage Specification
[Cell Reports] Researchers delineated the dynamics of TFAP2C during the mouse peri-implantation stage and elucidated its collaboration with the key lineage regulators CDX2 and NANOG.
Tbl1 Promotes Wnt/β-Catenin Signaling-Induced Degradation of the Tcf7l1 Protein in Mouse ESCs
[Journal of Cell Science] Investigators showed that the overexpression of transducin-β-like protein 1 (Tbl1) or its family member Tblr1 could decrease Tcf7l1 protein levels, while the knockdown of each increased Tcf7l1 levels without affecting Tcf7l1 transcription.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
