Volume 5.15 | Apr 21

ESC & iPSC News 5.15, April 21, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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TOP STORY

Chinese Scientists Discover Marker Indicating the Developmental Potential of Stem Cells
Researchers in China are reporting that they have found a way to determine which somatic cells, or differentiated body cells, that have been reprogrammed into a primordial, embryonic-like state are the most viable for therapeutic applications. [Press release from EurekAlert! discussing online prepublication in the Journal of Biological Chemistry]

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SCIENCE NEWS

Tohoku University Team Discovers New Type of Stem Cells in Human Skin, Bone
A research team from Tohoku University has discovered a new type of pluripotent stem cell in the skin and bone marrow of adults, providing a possible third source of stem cells after embryonic stem cells and human-made induced pluripotent stem cells. [Press release from The Mainichi Daily News discussing online prepublication in Proceedings of the National Academy of Sciences USA]

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CURRENT PUBLICATIONS

Histone Deacetylase 1 (HDAC1), but not HDAC2, Controls Embryonic Stem Cell Differentiation
This genetic study of HDAC1 and HDAC2 in embryonic stem cells, which mimic the embryonic epiblast, has identified a unique requirement for HDAC1 in the optimal activity of HDAC1/2 corepressor complexes and cell fate determination during differentiation. [Proc Natl Acad Sci U S A]

A Role for Borg5 During Trophectoderm Differentiation
Researchers report that differentiation of embryonic stem cells toward trophectoderm is accompanied by enhanced actin protrusion and cell motility that require up-regulation of Borg5. [Stem Cells]

The Transcription Factor TCFAP2C/AP-2Gamma Cooperates with CDX2 to Maintain Trophectoderm Formation
Researchers report that the transcription factor Tcfap2c is expressed at a high level in the trophectoderm and is able to induce trophoblast fate in embryonic stem cells. [Mol Cell Biol]

Activation of the Imprinted Dlk1-Dio3 Region Correlates with Pluripotency Levels of Mouse Stem Cells
In this study, investigators identified a conserved imprinted region of the mouse genome, the Dlk1-Dio3 region, which was activated in fully pluripotent mouse stem cells but repressed in partially pluripotent cells. [J Biol Chem]

Repression of Retrotransposal Elements in Mouse Embryonic Stem Cells is Primarily Mediated by DNA Methylation-Independent Mechanism
To determine whether intracisternal A-Particles (IAP) is also repressed in pluripotent stem cells by DNA methylation, researchers examined IAP expression in demethylated mouse embryonic stem cells and epiblast-derived stem cells. [J Biol Chem]

Variation in Hematopoietic Potential of Induced Pluripotent Stem Cell Lines
Researchers compare differentiation capacity of six induced pluripotent stem lines into mesodermal cells and hematopoietic cells through embryoid body formation. [Stem Cell Rev]

Alternative Sources of Pluripotent Stem Cells: Ethical and Scientific Issues Revisited
Ethically uncompromised stem cells, such as those derived by direct reprogramming or from germ-cell precursors are likely to yield important advances in stem cell research, and move the field rapidly towards clinical applications. [Stem Cells Dev]

Rederivation of Transgenic Mice from Induced Pluripotent Stem Cells Derived from Frozen Tissue
This study provides conclusive evidence that, as a practical matter, frozen tails and fibroblasts can be used as an effective and reliable alternative to frozen germplasm and embryonic stem cells for the storage, maintenance, and distribution of genetically-altered mutant mice. [Transgenic Res]

Derivation and Long-Term Culture of Human Parthenogenetic Embryonic Stem Cells Using Human Foreskin Feeders
This study indicates that homologous human fibroblasts can be used as feeder cells to support not only the propagation, but also the derivation of embryonic stem cells, and this should facilitate studies of therapeutic cloning for research and clinical applications. [J Assist Reprod Genet]

Preimplantation Mouse Embryo Selection Guided by Light-Induced Dielectrophoresis
Researchers present a method that exploits the scaling electrical properties of pre-transfer embryos to quantitatively discern embryo developmental maturity using light-induced dielectrophoresis. [PLoS One]



INDUSTRY NEWS

Einstein Receives $10 Million National Institutes of Health Grant to Expand Stem Cell Research Facilities
Albert Einstein College of Medicine of Yeshiva University has been awarded $10 million from the National Institutes of Health to expand its stem cell research capabilities. [Albert Einstein College of Medicine Press Release]

Regenerative Medicine Company Wants Biobusiness Center Space
A start-up biotech company will seek Rochester City Council approval to put a manufacturing facility in the Minnesota Biobusiness Center. [The Post-Bulletin]

Florida Biotech Research Money in Jeopardy
Florida researchers could lose $50 million in biomedical research funding due to the state’s $3 billion budget deficit. [Orlando Business Journal]

Quebec Biotechs in Tailspin
Once Canada’s envy, and in the same league as Boston and San Francisco, Quebec’s biotechnology industry is a shadow of its former self and in danger of disappearing, observers say. [The Gazette]



POLICY NEWS

Stem Cell Funding in Sight
Two of the most widely used embryonic stem cell lines could be just weeks away from being eligible for United States federal funding. [Obama Administration, United States]

Obama Picks Pragmatists for New Bioethics Panel
President Barack Obama named the members of his bioethics commission – headed by two university presidents. [National Bioethics Commission, United States]

Policy Reminder Concerning Appendix Materials for All National Institutes of Health/Agency for Healthcare Research and Quality/National Institute for Occupational Safety and Health Grant Applications (NOT-OD-10-077) [National Institutes of Health, United States]

Enhancing Peer Review: Clarification of Resubmission Policy and Determination of New Application Status (NOT-OD-10-080) [National Institutes of Health, United States]

Guidance on Confirming Appropriate Charges to NIH Awards during Periods of Noncompliance for Activities Involving Animals (NOT-OD-10-081) [National Institutes of Health, United States]

Update of Sample Animal Welfare Assurance for Foreign Institutions (NOT-OD-10-083) [National Institutes of Health, United States]

Agency for Healthcare Research and Quality Small Research Grant Program (R03) (PAR-10-168) [National Institutes of Health, United States]

Human Cell, Tissues and Cellular and Tissue-Based Products (HCT/P) List of Registered Establishments [Center for Biologics Evaluation and Research, United States]

Preparation for International Conference on Harmonisation Steering Committee and Expert Working Group Meetings in Tallinn, Estonia; Regional Public Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]



EVENTS

Society for Biological Engineering’s (SBE) 2nd International Conference on Stem Cell Engineering
May 2-5, 2010
Boston, United States

World Stem Cells & Regenerative Medicine Congress 2010
May 11-13, 2010
London, United Kingdom

European Molecular Biology Laboratory (EMBL) Stem Cells, Tissue Homeostasis and Cancer Conference
May 12-15, 2010
Heidelberg, Germany

16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – European Union 2010
June 13-17, 2010
Galway, Ireland

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

Select BioScience 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

International Society for Cell Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

Stem Cell Network 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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