Volume 5.18 | May 12

ESC & iPSC News 5.18, May 12, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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TOP STORY

Same Disease, Different Stem Cell Models: Fragile X Syndrome Induced Pluripotent Stem Cells and Embryonic Stem Cells Behave Differently
Induced pluripotent stem cells are different from embryonic stem cells in their ability to model a human genetic disease, a new cell-to-cell comparison shows. [Press release from Children’s Hospital Boston discussing online prepublication in Cell Stem Cell]

mFreSR_645x110_v01

SCIENCE NEWS

Scientists Create Human Embryonic Stem Cells with Enhanced Pluripotency
Researchers have converted established human induced pluripotent stem cells and human embryonic stem cells to a base state of greater pluripotency.  [Press release from the Whitehead Institute for Biomedical Research discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

Tumor Promoter Aids Stem Cell Reproduction
A signalling pathway known to promote tumors is also involved in the pluripotent regulation of embryonic stem cells. [Press release from eCancerMedicalScience discussing online prepublication in Acta Pharmacologica Sinica]

mTeSR  
Derive iPSCs feeder-free* with mTeSR®1
by STEMCELL Technologies
 
 
*Sun et al., PNAS, 2009 STEMCELL Technologies Inc
 


CURRENT PUBLICATIONS (Ranked by Impact Factor)

Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
These data highlight critical differences between embryonic stem cells and induced pluripotent stem cells in modeling fragile X disorder. [Cell Stem Cell]

Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells
Researchers report that epigenomic landscapes in human embryonic stem cells and lineage-committed cells are drastically different. [Cell Stem Cell]

Tracing the Derivation of Embryonic Stem Cells from the Inner Cell Mass by Single-Cell RNA-Seq Analysis
Researchers detected significant molecular transitions and major changes in transcript variants, which include genes for general metabolism. Furthermore, the expression of repressive epigenetic regulators increased with a concomitant decrease in gene activators that might be necessary to sustain the inherent plasticity of embryonic stem cells. [Cell Stem Cell]

Multiple Epigenetic Modifiers Induce Aggressive Viral Extinction in Extraembryonic Endoderm Stem Cells
These results further the understanding of mechanisms regulating retroviral transcription in different stem cell lineages. [Cell Stem Cell]

Human Embryonic Stem Cells (ESCs) with Biological and Epigenetic Characteristics Similar to Those of Mouse ESCs
Here, researchers rewire the identity of conventional human ESCs into a more immature state that extensively shares defining features with pluripotent mouse ESCs. [Proc Natl Acad Sci U S A ]

The Enhancement of Human Embryonic Stem Cell Osteogenic Differentiation with Nano-Fibrous Scaffolding
The data indicates that the nanofibrous architecture enhances the osteogenic differentiation of the human embryonic stem cells compared to more traditional scaffolding architecture. [Biomaterials]

Rac1 is Essential for Basement Membrane-Dependent Epiblast Survival
Researchers demonstrate that Rac1 ablation in embryonic stem cell-derived embryoid bodies leads to massive apoptosis of epiblast cells in contact with the basement membrane. [Mol Cell Biol]

Glycoproteomic Analysis of Embryonic Stem Cells: Identification of Potential Glycobiomarkers Using Lectin Affinity Chromatography of Glycopeptides
In this study, the glycoproteomic characterization of pluripotent murine embryonic stem cells (ES) and from ES cells that were differentiated into embryoid bodies was performed using immobilized Concanavalin A. [J Proteome Res]

Promotion of Self-Renewal of Embryonic Stem Cells by Midkine
Midkine/PTP-zeta signaling pathway is a novel pathway in the signal network maintaining pluripotency of embryonic stem cells (ESCs). The results extend knowledge on pluripotency control of ESCs and the relationship between ESCs and cancers. [Acta Pharmacol Sin]



INDUSTRY NEWS

Cellular Dynamics Partners with iPS Academia Japan, Inc. to In-License Seminal iPS Cell Patent Portfolio
Cellular Dynamics International, Inc. and iPS Academia Japan, Inc. announced a nonexclusive licensing agreement for the seminal induced pluripotent stem cell (iPSC) patent portfolio arising out of the work of Dr. Shinya Yamanaka, M.D, Ph.D., Center for iPS Cell Research and Application, Kyoto University. [Cellular Dynamics International, Inc. Press Release]

Osiris Therapeutics Receives FDA Orphan Drug Designation for Stem Cell Treatment for Type 1 Diabetes
Osiris Therapeutics, Inc. announced that it has been granted Orphan Drug designation from the U.S. Food and Drug Administration (FDA) for Prochymal as a treatment for type 1 diabetes mellitus. [Osiris Therapeutics, Inc. Press Release]

BioTime Announces Receipt of $8 Million from Early Exercise of Warrants
BioTime, Inc., a biotechnology company that develops and markets products in the field of human stem cells and regenerative medicine, announced that it has received an additional $8 million from two investors. [BioTime, Inc. Press Release]

University of California, Irvine to Dedicate Sue and Bill Gross Hall: A California Institute for Regenerative Medicine (CIRM) Institute
University of California Irvine will dedicate its $80-million, 100,000-square-foot stem cell research building Friday, May 14. Sue and Bill Gross Hall: A CIRM Institute is the first major stem cell center in Southern California, a region known for biomedical innovation. [University of California, Irvine Press Release]

March of Dimes Awards $250,000 Prize to Scientist Who Discovered How to Reprogram Human Cells
The March of Dimes awarded Shinya Yamanaka, MD, PhD its 2010 Prize in Developmental Biology. [March of Dimes Press Release]

POLICY NEWS

NSF to Ask Every Grant Applicant for Data Management Plan
Scientists seeking funding from the National Science Foundation (NSF) will soon need to spell out how they plan to manage the data they hope to collect. It’s part of a broader move by NSF and other federal agencies to emphasize the importance of community access to data. [National Science Foundation, United States]

Montgomery Council Gives the Go-Ahead to ‘Science City’ Plan
County officials hope the development, which could be two decades in the making, could position Montgomery as an international center for biosciences that would rival North Carolina’s Research Triangle or Palo Alto, Calif. The county is home to almost 300 biotech companies and institutions. [Montgomery County Council, United States]

Granholm Announces Stem Cell Public Education Day
Governor Jennifer M. Granholm announced at a press conference in Chicago that the World Stem Cell Summit will kick off with a free “Public Education Day” on October 3 at the Detroit Science Center. [Michigan, United States]

With Hung Parliament, British Scientists Wonder Who’s the Boss?
On May 7, 2010, Britain woke up to an uncertain political future-and British scientists continue to remain in the dark about how expected government funding cuts will slice into research efforts. [Parliament of the United Kingdom, United Kingdom]

Training Australian Scientists in Latest Stem Cell Discoveries
For the first time in Australia, young researchers will be trained in the techniques of growing and using human induced pluripotent stem cells in research. [Australian Stem Cell Centre, Australia]

Qatar Stem Cell Research Policy Most Liberal
Qatar is forging ahead on stem cell research with one of the most permissible policies set down. The transparent guidelines that explain almost every aspect of the research even allows embryonic stem cell research which is still a controversy or illegal in many parts of the world. [Qatar Foundation, United Arab Emirates]

Notice of Funding Opportunity for a Cell Characterization Core for the National Heart, Lung and Blood Institute Progenitor Cell Biology Consortium (NOT-HL-10-109) [National Institutes of Health, United States]

Enhancing Peer Review: Expectation for Service on NIH Peer Review and Advisory Groups (NOT-OD-10-089) [National Institutes of Health, United States]

Drug Safety and Risk Management Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Agency Information Collection Activities; Proposed Collection; Comment Request; Experimental Study of Patient Information Prototypes [Docket No. FDA-2010-N-0184] [Food and Drug Administration, United States]

EVENTS

16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

Stem Cell Investor & Executive Networking Conference Event (S.C.I.E.N.C.E.)
June 1, 2010
New York, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – European Union 2010
June 13-17, 2010
Galway, Ireland

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
August 17-19, 2010
Cambridge, United States

Select BioSciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

International Society for Cell Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

Stem Cell Network 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States


Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



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