Volume 5.23 | Jun 16

ESC & iPSC News 5.23, June 16, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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TOP STORY

Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming
Somatic cell reprogramming using chromatin-remodeling molecules represents an efficient method of generating reprogrammed cells. [Cell]

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SCIENCE NEWS

Obstacles to Stem Cell Therapy Cleared
Researchers have come up with a new technique to prevent tumors developing in connection with stem cell transplantations. [Press release from Lund University discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Tracking Differentiating Neural Progenitors in Pluripotent Cultures Using MicroRNA-Regulated Lentiviral Vectors
In this study, researchers used a microRNA-regulated lentiviral reporter system to visualize and segregate differentiating neuronal cells in pluripotent cultures. [Proc Natl Acad Sci U S A]

Rare Cell Proteomic Reactor Applied to SILAC Based Quantitative Proteomic Study of Human Embryonic Stem Cell Differentiation
A fully-integrated proteomics sample processing and analysis platform, termed rare cell proteomic reactor, was developed for large-scale quantitative proteomic analysis of human embryonic stem cells with approximately 50,000 cells. [Mol Cell Proteomics]

Cripto-1 is a Cell-Surface Marker for a Tumorigenic, Undifferentiated Subpopulation in Human Embryonal Carcinoma Cells
Results demonstrate that Cripto-1 expression is enriched in an undifferentiated, tumorigenic subpopulation and is regulated by key regulators of pluripotent stem cells. [Stem Cells]

Cell Line-Dependent Differentiation of Induced Pluripotent Stem Cells into Cardiomyocytes in Mice
Mouse induced pluripotent stem (iPS) cells differentiate into cardiomyocytes in a cell-line dependent manner. Trichostatin A induces myocardial differentiation in mouse iPS cells, and might be useful to overcome cell line variation in the differentiation efficiency. [Cardiovasc Res]

Unique Differentiation Profile of Mouse Embryonic Stem Cells in Rotary and Stirred Tank Bioreactors
Researchers conclude that bioreactor type and culture parameters can be used to control embryonic stem cell differentiation, enhance unique progenitor cell populations and provide means for large scale production of transplantable therapeutic cells. [Tissue Eng Part A]

Osteogenic Potential of Human Mesenchymal Stem Cells and Human Embryonic Stem Cell-Derived Mesodermal Progenitors: A Tissue Engineering Perspective
The high osteogenic ability of human embryonic stem cell-derived mesodermal progenitors, together with a low expression of HLA class II, make these cells an attractive alternative for bulk production of cells for bone engineering applications. [Tissue Eng Part A]

Viable Fertile Mice Generated from Fully Pluripotent iPS Cells Derived from Adult Somatic Cells
Researchers successfully generated high-pluripotency induced pluripotent stem (iPS) cells from adult tail tip fibroblasts (TTF) that resulted in viable, full-term, fertile TTF-iPS animals with no obvious teratoma formation or other developmental abnormalities. [Stem Cell Rev]

Efficient Derivation of Pluripotent Stem Cells from siRNA-Mediated Cdx2-Deficient Mouse Embryos
Results demonstrate that Cdx2 plays an essential role within the microenvironment created by the trophectoderm to support inner cell mass pluripotency, but that the embryonic stem cell (ESC) culture system, with mouse embryonic fibroblasts, could rescue the pluripotent cell population for efficient ESC derivation. [Stem Cells Dev]

Induction of Pluripotency in Human Cord Blood Unrestricted Somatic Stem Cells
Cord blood induced pluripotent stem cells are highly similar to human embryonic stem cells morphologically, at their molecular signature as well as in their differentiation potential. [Exp Hematol]

Hes1 Regulates Embryonic Stem Cell Differentiation by Suppressing Notch Signaling
Results indicate that sustained Hes1 expression delays the differentiation of embryonic stem cells and promotes the preference for the mesodermal rather than the neural fate by suppression of Notch signaling. [Genes Cells]


INDUSTRY NEWS

STEMCELL Technologies is Proud to Announce STEMcircles™, a Virus-Free Technology for Reprogramming Cells
STEMCELL Technologies, Inc. announced that they have signed a licensing agreement with Stanford University for a virus-free technique used for the generation of induced pluripotent stem cells. [STEMCELL Technologies, Inc. Press Release]

Lonza Announces Worldwide, Exclusive Licensing and Supply Agreements with California Stem Cell Inc.
Lonza Inc. has entered worldwide, exclusive licensing and supply agreements with California Stem Cell Inc. This collaboration makes novel pluripotent stem cell products readily available to researchers worldwide. [Lonza Inc. Press Release]

Promega and Cellular Dynamics Partner to Validate Stem Cell-Based In Vitro Assays for Predicting Drug-Induced Cardiotoxicity
Cellular Dynamics International and Promega have entered into a research collaboration with the goal of bringing more relevant and highly predictive toxicity testing to the drug discovery process. [Cellular Dynamics International Press Release]

Southern California Cell Company Partners with Northern California Life Science Research Technology Company for Developing Human Derived Disease Specific iPS Cell Lines
DV Biologics, LLC announced that it has executed an agreement with System Biosciences, LLC for the development of human-derived disease-specific induced pluripotent stem (iPS) cell lines. [DV Biologics, LLC Press Release]

Gladstone and Institute for Systems Biology Collaborate to Discover New Genes Associated with the Onset of Huntington’s Disease
The Institute for Systems Biology is collaborating with the Gladstone Institute of Neurological Disease and its Taube-Koret Center for Huntington’s Disease Research to use whole-genome sequencing to identify genes and novel drug targets related to the onset and progression of Huntington’s disease. [The Institute for Systems Biology Press Release]

Connecticut Awards $9.8 Million in Stem Cell Research Grants
Connecticut state has awarded $9.8 million in grants to support nearly two dozen stem cell research projects by scientists at the University of Connecticut and at Yale. [State of Connecticut Press Release]

NIH Approves Advanced Cell Technology’s Stem Cell Line for Federal Funding
Advanced Cell Technology, Inc. announced that human embryonic stem cell line MA135 was unanimously approved for federal funding at the 100th Meeting of the Advisory Committee to the Director National Institutes of Health (NIH). [Advanced Cell Technology, Inc. Press Release]

Advanced Cell Technology Awarded Broad Patent for Production of Retinal Pigment Epithelial Cells
Advanced Cell Technology, Inc. (ACT) announced that it has been issued U.S. Patent Number 7736896, which is broadly directed to processes developed by ACT scientists for the production of retinal pigment epithelial cells from human embryonic stem cells. [Advanced Cell Technology, Inc. Press Release]

Companies Pledge to Make More Trial Data Public
An international organization of pharmaceutical companies has adopted new guidelines governing the publication of clinical trial results. The policy calls for the industry to publish the results of late-stage, ‘phase III’ clinical trials in peer-reviewed journals, regardless of the trials’ outcome. [NatureNews Press Release]


POLICY NEWS

The Path to Personalized Medicine
The leaders of the National Institutes of Health and the Food and Drug Administration have a shared vision of personalized medicine and the scientific and regulatory structure needed to support its growth. Together, they have been focusing on the best ways to develop new therapies and optimize prescribing by steering patients to the right drug at the right dose at the right time. [The National Institutes of Health and the Food and Drug Administration, United States]

Diseased Cells Fail to Win Approval
In the latest obstacle to expanding the number of embryonic stem-cell lines eligible for US federal funding, a National Institutes of Health committee has unanimously rejected dozens of cell lines carrying mutations for specific diseases. [National Institutes of Health, United States]

NIH Researchers Explore How Healthy, Young Adults View the Role Genetics Plays in Improving Health
Most healthy young adults place greater emphasis on health habits than on genetic risk factors when considering what causes common diseases, a research team from the National Human Genome Research Institute and the Henry Ford Health System in Detroit has found. [National Institutes of Health, United States]

Hospital Clinic de Barcelona Obtained the First Accreditation for Cell Therapy Research
The certification, awarded for the first time in Catalonia, allows the Hospital Clinic de Barcelona to produce drugs in gene therapy, cell therapy and tissue engineering. [Spanish Medicines Agency, Spain]

Enhancing Peer Review: Advance Notice on Post-Submission Application Materials for NIH Training and Related Applications (NOT-OD-10-104) [National Institutes of Health, United States]

PFINDR: Phenotype Finder IN Data Resources: A Tool to Support Cross-study Data Discovery Among NHLBI Genomic Studies (UH2/UH3) (RFA-HL-11-020) [National Institutes of Health, United States]

Final Report of The National Academies’ Human Embryonic Stem Cell Research Advisory Committee and 2010 Amendments to the National Academies’ Guidelines for Human Embryonic Stem Cell Research [National Academy of Sciences, United States]

Roster of the Cellular, Tissue and Gene Therapies Advisory Committee [Center for Biologics Evaluation and Research, United States]



EVENTS

Worldwide Innovative Networking (WIN) Symposium in Personalized Cancer Medicine
July 7-9, 2010
Paris, France

United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom


2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore


Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit

August 24-25, 2010
Edinburgh, Scotland


International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy


Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States


Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany


Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany


Select Biosciences 2nd International Forum on Stem Cells
November 12-13, 2010
Tianjin, China


Stem Cell Network 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States


Stem Cells World Congress
January 24-25, 2011
San Diego, United States


Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


 

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