Volume 5.29 | Jul 28

ESC & iPSC News 5.29, July 28, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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RNA Offers a Safer Way to Reprogram Cells 
Researchers have shown, for the first time, that they can deliver reprogramming genes using RNA. This method could prove much safer than DNA-based reprogramming. [Press release from Massachusetts Institute of Technology discussing online prepublication in PLoS One]

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Pluripotent Stem Cells Model Cardiac Disease Mechanisms
Researchers have successfully generated pluripotent stem cells capable of recapitulating certain aspects of long-QT syndrome type 1. [Press release from ModernMedicine discussing online prepublication in the New England Journal of Medicine]

Scientists ‘Reprogram’ Mouse Fat Cells into Clinically Useful Stem Cells
Scientists from the Monash Institute of Medical Research have “reprogrammed” adult mouse fat cells and neural cells to become induced pluripotent stem cells. [Press release from EurekAlert! discussing online prepublication in Cell Transplantation]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome
Researchers generated patient-specific pluripotent stem cells from members of a family affected by long-QT syndrome type 1 and induced them to differentiate into functional cardiac myocytes. The patient-derived cells recapitulated the electrophysiological features of the disorder. [N Engl J Med]

Promotion of Direct Reprogramming by Transformation-Deficient Myc
Researchers report that the promotion of induced pluripotent stem cell generation by Myc is independent of its transformation property. [Proc Natl Acad Sci U S A]

Generation of Genetically Modified Rats from Embryonic Stem Cells
To monitor the pluripotency of rat embryonic stem cells, researchers generated Oct4-Venus transgenic rats via a conventional method, in which Venus is expressed by the Oct4 promoter/enhancer. [Proc Natl Acad Sci U S A]

Deletion of TDP-43 Down-Regulates Tbc1d1, a Gene Linked to Obesity, and Alters Body Fat Metabolism
Results establish that Tat activating regulatory DNA-binding protein (TDP-43) is critical for fat metabolism and embryonic stem cell survival. [Proc Natl Acad Sci U S A]

Synthesized Basement Membranes Direct the Differentiation of Mouse Embryonic Stem Cells into Pancreatic Lineages
On a synthesized basement membrane, mouse embryonic stem or induced pluripotent stem cells sequentially differentiated into the definitive endoderm, pancreatic progenitor cells, and then insulin-expressing pancreatic beta cells in vitro. [J Cell Sci]

Cell Line-Dependent Differentiation of Induced Pluripotent Stem Cells into Cardiomyocytes in Mice
Mouse induced pluripotent stem (iPS) cells differentiate into cardiomyocytes in a cell line-dependent manner. Trichostatin A induces myocardial differentiation in mouse iPS cells and might be useful to overcome cell line variation in the differentiation efficiency. [Cardiovasc Res]

The Efficient Generation of Induced Pluripotent Stem (iPS) Cells From Adult Mouse Adipose Tissue-Derived and Neural Stem Cells
Findings confirm that adipose tissue-derived cells are an ideal candidate as a readily accessible somatic cell type for high efficiency establishment of iPS cell lines. [Cell Transplant]

Involvement of Caveolin-1 in Fibronectin-Induced Mouse Embryonic Stem Cell Proliferation: Role of FAK, RhoA, PI3K/Akt, and ERK 1/2 Pathways
Researchers conclude that fibronectin stimulates mouse embryonic stem cell proliferation via RhoA-PI3K/Akt-ERK 1/2 pathway through caveolin-1 phosphorylation. [J Cell Physiol]

Application of Induced Pluripotent Stem (iPS) Cells in Periodontal Tissue Regeneration
iPS cells combined with enamel matrix derivative provide a valuable tool for periodontal tissue engineering, by promoting the formation of new cementum, alveolar bone, and normal periodontal ligament. [J Cell Physiol]

Innate Immune Suppression Enables Frequent Transfection with RNA Encoding Reprogramming Proteins
Researchers show that combined knockdown of interferon-beta (Ifnb1), Eif2ak2, and Stat2 rescues cells from the innate immune response triggered by frequent long-RNA transfection. Using this technique, they were able to transfect primary human fibroblasts every 24 hours with RNA encoding the reprogramming proteins Oct4, Sox2, Klf4, and Utf1. [PLoS One]


USF, Jackson to Partner on Biomedical Village
Jackson Laboratory is launching a biomedical research and education village in Collier County, and the University of South Florida (USF) is its first medical partner. [University of South Florida Press Release]

International Stem Cell Plans $10 Million Financing Through European Subsidiary
International Stem Cell Corporation announced that it had entered into a Memorandum of Understanding with ARG Vermogensverwaltung AG, a German Investment Fund, to create a new European subsidiary to be funded with up to $10 million of capital derived from ARG and other independent sources in Europe. [International Stem Cell Corporation Press Release]

BioTime Announces Addition of New Stem Cell Lines to Its Product Portfolio
BioTime, Inc. announced that on August 1, 2010 the Company will be offering for sale 21 new stem cell products for research use only. [Yahoo! Finance]

New Health Care Leaders Named
News outlets report on new leadership appointments at key health care groups. [The Medical News]

Finance Secretary for Scotland Explores the Options of Jobs in Life Sciences
Finance Secretary John Swinney met with senior managers at Merck MSD in Newhouse to explore options to protect and sustain employment in the area. [eGov Monitor]


NIH Takes on New Role in Fight Against Rare Diseases
A government program focusing on rare diseases, the Therapeutics for Rare and Neglected Diseases (TRND) program, has launched five pilot projects that are taking the National Institutes of Health in a new direction: developing drugs. TRND will work together with scientists, advocates and others to do the required research and testing on drugs before a compound can be tried in humans in a clinical trial. [National Institutes of Health, United States]

NIH Asks for Input on Closing Loophole in Conflict-of-Interest Rule
Responding to yet another flap about the influence of drug companies on biomedical research, the National Institutes of Health (NIH) has decided it needs more time to revise its rules for policing conflicts of interest so that sanctions will move with an investigator if he or she changes institutions. [National Institutes of Health, United States]

Responsibility of Applicants for Promoting Objectivity in Research for Which Public Health Service Funding Is Sought and Responsible Prospective Contractors [Docket Number NIH-2010-0001] [Department of Health and Human Services, United States]

National Institute of General Medical Sciences; Notice of Closed Meeting (Doc. 2010-18088) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (Doc. 2010-18052) [National Institutes of Health, United States]

Instrument Development for Biomedical Applications (R21) (RFA-RR-10-009) [National Institutes of Health, United States]

Bioengineering Research Partnerships (BRP)[R01] (PAR-10-234) [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering Program Project (P01) Applications (PAR-10-233) [National Institutes of Health, United States]


Cold Spring Harbor Workshop on Stem Cells
July 30-August 5, 2010
Cold Spring Harbor, United States

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010

9th Mount Desert Island Stem Cell Symposium
August 6-7, 2010
Salsbury Cove, United States

Select Biosciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

Select Biosciences Inaugural Cellular Therapy Summit

August 24-25, 2010
Edinburgh, Scotland

Select Biosciences 2nd Annual World Biobanking Summit
August 24-25, 2010
Edinburgh, Scotland

International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
September 11-17, 2010
Hydra, Greece

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th Annual Meeting of the German Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine
October 7, 2010
Hertfordshire, United Kingdom

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

Select Biosciences 2nd International Forum on Stem Cells
November 12-13, 2010
Tianjin, China

Stem Cell Network 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

NEW Biotech Showcase 2011
January 10-12, 2011
San Francisco, USA

Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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