Volume 5.33 | Aug 25

ESC & iPSC News 5.33, August 25, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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A Better Way to Grow Stem Cells 
Researchers have devised a synthetic surface that includes no foreign animal material and allows stem cells to stay alive and continue reproducing themselves for at least three months. [Press release from the Massachusetts Institute of Technology discussing online prepublication in Nature Materials]



Stem Cells from the Thymus Reprogrammed to Become Skin Stem Cells
The study shows that stem cells from the thymus can function as hair follicle stem cells and contribute to the long-term maintenance of the skin. [Press release from the Medical Research Council Centre for Regenerative Medicine discussing online prepublication in Nature]

Stem Cell First
Researchers have created induced pluripotent stem cells from human skin without the use of viruses or genetic manipulation, an important step toward their eventual use in treating human disease. [Press release from the University of New South Wales discussing online prepublication in PLoS One]

Derive iPSCs feeder-free* with mTeSR®1
by STEMCELL Technologies
*Sun et al., PNAS, September 2009.
*Chan et al., Nature Biotechnology, October 2009.
STEMCELL Technologies Inc

CURRENT PUBLICATIONS  (Ranked by Impact Factor of the Journal)

Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells
Researchers show that the thymus of the rat contains a population of clonogenic thymic epithelial cells that can be extensively cultured while conserving the capacity to integrate in a thymic epithelial network and to express major histocompatibility complex class II molecules and Aire. [Nature]

Combinatorial Development of Biomaterials for Clonal Growth of Human Pluripotent Stem Cells
Researchers develop the first chemically defined, xeno-free, feeder-free synthetic substrates to support robust self-renewal of fully dissociated human embryonic stem and induced pluripotent stem cells. [Nat Mater]

Female Human iPSCs Retain an Inactive X Chromosome
Results indicate that human induced pluripotent stem cells (iPSCs) are epigenetically dynamic and do not display a pristine state of X inactivation with two active Xs as found in some female human embryonic stem cell lines. [Cell Stem Cell]

Canonical Wnt/Beta-Catenin Regulation of Liver Receptor Homolog-1 (Lrh-1) Mediates Pluripotency Gene Expression
Researchers present genetic, molecular, and pharmacological studies identifying a signaling axis in which beta-catenin promotes pluripotency gene expression in an Lrh-1-dependent manner. [Stem Cells]

High-Efficiency Induction of Neural Conversion in hESCs and hiPSCs with a Single Chemical Inhibitor of TGF-Beta Superfamily Receptors
Researchers identified compound C (also denoted as dorsomorphin), a protein kinase inhibitor, as a potent regulator of human embryonic stem cell (hESC) and human induced pluripotent stem cell (hiPSC) fate decisions. [Stem Cells]

A Role for Regulatory T Cells in Acceptance of Embryonic Stem Cell-Derived Tissues Transplanted Across an MHC Barrier
Researchers demonstrate that fully allogeneic embryonic stem cell-derived tissues are accepted with a regimen of coreceptor blockade even in recipients known to be relatively resistant to such a tolerizing protocol. [Stem Cells]

Generation of Microglial Cells from Mouse Embryonic Stem Cells
Researchers describe a basic protocol for the in vitro differentiation of mouse embryonic stem cells into microglial precursor cells. [Nat Protoc]

Factors from Human Embryonic Stem Cell-Derived Fibroblast-Like Cells Promote Topology-Dependent Hepatic Differentiation in Primate Embryonic and Induced Pluripotent Stem Cells
Researchers describe a novel in vitro differentiation model, and show that human embryonic stem cell (ESC)-derived fibroblast-like cell-secreted factors act in concert with regional features of ESC colonies to induce robust hepatic endoderm differentiation in primate pluripotent stem cells. [J Biol Chem]

A Combined Epigenetic and Non-Genetic Approach for Reprogramming Human Somatic Cells
Researchers report the first application of a combined epigenetic and non-genetic approach for reprogramming somatic cells, i.e., DNA methyltransferase and histone deacetylase inhibitors, and human embryonic stem cell extracts. [PLoS One]

Dynamic MicroRNA Expression Programs During Cardiac Differentiation of Human Embryonic Stem Cells: Role for miR-499
The data give significant insight into the regulatory networks that govern human embryonic stem cell (hESC) differentiation, and highlights the ability of microRNAs to perturb, and even control, the genes that are involved in cardiac specification of hESCs. [Circ Cardiovasc Genet]


Proteonomix, Inc. Announces Joint Venture in the United Arab Emirates
Proteonomix, Inc. announced that it has executed a joint venture agreement with a group of investors that will create a new stem cell treatment and research facility in the United Arab Emirates. [Proteonomix, Inc. Press Release]
Stem Cell Agency Commits $243 Million, Expands Team Approach to Developing New Therapies
The Governing Board of the California Institute for Regenerative Medicine approved the concept for up to $243 million round of funding to move stem cell-based therapies to clinical trial. [California Institute for Regenerative Medicine Press Release]

BioTime Raises $9.2 Million in Warrant Discount Offer
BioTime, Inc. announced the completion of its warrant discount offer. [BioTime, Inc. Press Release]


Federal Judge: Obama Stem Cell Policy Halted
Research on embryonic stem cells funded by the U.S. government must stop immediately for a court-ordered review, Judge Royce Lamberth of the U.S. District Court for the District of Columbia ruled. [United States District Court for the District of Columbia]
NIH Director Collins Says Cell Ruling Won’t Halt Most Ongoing Grants
National Institutes of Health (NIH) Director Francis Collins said that the court injunction blocking federally funded research on human embryonic stem cells will not affect grant payments that have already gone out the door this year. [National Institutes of Health, United States]
Universities, Scientists Urge NIH to Narrow Conflicts Rule
The biomedical research community is reacting with concern to a proposal from the National Institutes of Health (NIH) to clamp down on financial conflicts of interest in research. [National Institutes of Health, United States]
Lawrence A. Tabak Named Principal Deputy Director NIH
National Institutes of Health Director Francis S. Collins, M.D., Ph.D., announced the appointment of Lawrence A. Tabak, D.D.S., Ph.D., as principal deputy director of the National Institutes of Health. [National Institutes of Health, United States]
Food and Drug Administration Clinical Trial Requirements, Regulations, Compliance, and Good Clinical Practice; Public Workshop [Docket No. FDA-2010-N-0001] [Food and Drug Administration, United States]

Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) (RFA-GM-11-003) [National Institutes of Health, United States]
NIH-RAID Updates on Program Scope and Procedures: Biologics Manufacture, Lead Selection, and Product Development Plans (NOT-RM-10-012) [National Institutes of Health, United States]
Proposed Collection; Comment Request; STAR METRICS–Science and Technology in America’s Reinvestment: Measuring the Effects of Research on Innovation, Competitiveness and Science (FR Doc. 2010-20614) [National Institutes of Health, United States]
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-20588) [National Institutes of Health, United States]

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-20675) [National Institutes of Health, United States]
Support of National Institute of General Medical Sciences Program Project Grants (P01) (PAR-10-266) [National Institutes of Health, United States]
Limited Pilot for National Institute of General Medical Sciences Legacy Community-Wide Scientific Resources (R24) (PAR-10-261) [National Institute of General Medical Sciences, United States]
Submission for Office of Management and Budget Review; Comment Request; Resource for the Collection and Evaluation of Human Tissues and Cells from Donors With an Epidemiology Profile (NCI) (FR Doc. 2010-21098) [National Institutes of Health, United States]


International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
September 11-17, 2010
Hydra, Greece

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

5th Annual Meeting of the German Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine
October 7, 2010
Hertfordshire, United Kingdom

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

BioMalaysia 2010 Conference and Exhibition
November 2-4, 2010
Kuala Lumpur, Malaysia

Select Biosciences 2nd International Forum on Stem Cells
November 12-13, 2010
Tianjin, China

Stem Cell Network 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Biotech Showcase 2011
January 10-12, 2011
San Francisco, United States 

Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



Cell Therapy Technologist (Opexa Therapeutics)

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