Volume 5.36 | Sep 15

ESC & iPSC News 5.36, September 15, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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Spontaneous Irs1 Passenger Mutation Linked to a Gene-Targeted SerpinB2 Allele 
Spontaneous mutations arising during embryonic stem cell culture may be a frequent but underappreciated occurrence. When linked to a targeted allele, such mutations could lead to incorrect assignment of phenotype and may account for a subset of markedly discordant results from experiments independently targeting the same gene. [Proc Natl Acad Sci U S A]



Researchers Create iPS Cells from Human Gums
A team of researchers has succeeded in creating induced pluripotent stem (iPS) cells from human gums. [Press release from The Mainichi Daily News discussing online prepublication in PLoS One]


CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Ontogeny-Recapitulating Generation and Tissue Integration of ES Cell-Derived Purkinje Cells
Researchers found that Purkinje cells could be robustly generated from mouse embryonic stem (ES) cells by recapitulating the self-inductive signaling microenvironments of the isthmic organizer. [Nat Neurosci]

Rare Cell Proteomic Reactor Applied to SILAC Based Quantitative Proteomic Study of Human Embryonic Stem Cell Differentiation
A fully-integrated proteomics sample processing and analysis platform, termed rare cell proteomic reactor, was developed for large-scale quantitative proteomic analysis of human embryonic stem cells with approximately 50,000 cells. [Mol Cell Proteomics]

Using Growth Factor Arrays and Micropatterned Co-Cultures to Induce Hepatic Differentiation of Embryonic Stem Cells
Instead of supplementing culture media with soluble growth factors (GFs), researchers investigated cultivation and differentiation of mouse embryonic stem cells on printed arrays of GFs. [Biomaterials]

Differential Roles of Sall4 Isoforms in Embryonic Stem Cell Pluripotency
By genome wide location analysis researchers have determined that Sall4a and Sall4b have overlapping, but not identical binding sites within the embryonic stem cell genome. [Mol Cell Biol]

Human Embryonic Stem Cells and Metastatic Colorectal Cancer Cells Shared the Common Endogenous Human MicroRNA-26b
Microarrays were used to analyze the global expression of miRNAs in a human embryonic stem cell line (i.e. HUES-17) and four colorectal cancer cell lines (i.e. LoVo, SW480, HT29 and Caco-2) with different metastatic potentialities. [J Cell Mol Med]

Gingival Fibroblasts as a Promising Source of Induced Pluripotent Stem Cells
Results suggest that gingival fibroblasts from the easily obtainable gingival tissues can be readily reprogrammed into induced pluripotent stem cells, thus making them a promising cell source for investigating the basis of cellular reprogramming and pluripotency for future clinical applications. [PLoS One]

Pro-Arrhythmic Risk of Embryonic Stem Cell-Derived Cardiomyocytes Transplantation in Infarcted Myocardium
Results demonstrate that transplantation of un-differentiated embryonic stem cells (ESCs) and ESC derived-cardiomyocytes provide similar improvement in cardiac function post-myocardial infarction. [Heart Rhythm]

PDCD2 Is Essential for Inner Cell Mass Development and Embryonic Stem Cell Maintenance
Results indicate that in vivo, PDCD2 is critical for blastomere and embryonic stem cell maintenance by contributing to the regulation of genes in a manner essential to the undifferentiated state of these cells. [Dev Biol]

Undifferentiated Propagation of the Human Embryonic Stem Cell Lines, H1 and HSF6, on Human Placenta-Derived Feeder Cells Without Basic Fibroblast Growth Factor Supplementation
Findings may support the hypothesis that human placenta-derived feeder cells (HPCs) enhance endogenous basic fibroblast growth factor production and activation of the ERK1/2-c-Fos/c-Jun pathway, which suggests that HPCs have an additional advantage in their human embryonic stem cell propagation compared with mouse embryonic fibroblast. [Stem Cells Dev]


STEMSOFT® Software Inc. Licenses StemLab® Software to Arizona’s Celebration Stem Cell Centre
STEMSOFT Software Inc., the leading provider of software solutions for the cell therapy and transplant community, is pleased to announce the licensing of StemLab, the leading cell therapy and cord blood banking laboratory software, to the Celebration Stem Cell Centre in Gilbert, Arizona. [STEMSOFT Software Inc. Press Release]

Geron Obtains Exclusive License for Deriving Cartilage from Human Embryonic Stem Cells from University of Edinburgh
Geron Corporation announced that it has entered into a worldwide, exclusive license agreement with the University of Edinburgh covering technology that allows the efficient production of chondrocytes from human pluripotent stem cells. [Geron Corporation Press Release]

Geron Announces Collaboration with University Campus Suffolk to Develop Human Embryonic Stem Cell-Derived Chondrocytes for Cartilage Repair
Geron Corporation announced that the company has entered into a collaboration with University Campus Suffolk in the U.K. to develop human embryonic stem cell-derived chondrocytes for the treatment of cartilage damage and joint disease. [Geron Corporation Press Release]

AstraZeneca and UCL Join Forces in Sight-Related Stem Cell Medicine
AstraZeneca and University College London (UCL) have entered into a collaboration to develop regenerative medicines for diabetic retinopathy. [University College London Press Release]

RTI Biologics and Athersys Announce Collaboration in the Orthopedic Market
RTI Biologics Inc. (RTI) and Athersys Inc. announced an agreement under which Athersys will provide RTI access to its Multipotent Adult Progenitor Cell technologies. [Athersys Inc. Press Release]

Data from Clinical Trials Show Pluristem’s Placenta-Derived Cell Therapy is Safe and Improves Quality of Life and Efficacy Measurements in Patients with Critical Limb Ischemia
Pluristem Therapeutics Inc. reported that data from clinical trials show the Company’s placenta-derived cell therapy, PLX-PAD, is safe and improves quality of life as well as other efficacy measurements in patients with critical limb ischemia. [Pluristem Therapeutics Inc. Press Release]

Advanced Cell Technology Lands Patents for Stem Cell-Derived Eye Treatment
Advanced Cell Technology Inc. has won two patents related to its stem cell-derived regenerative technology used to treat eye disorders. [Mass High Tech]

Maryland Stem Cell Research Commission to Host Third Annual Maryland Stem Cell Research Symposium
The Maryland Stem Cell Research Commission will host the Third Annual Maryland Stem Cell Research Symposium in partnership with the National Institutes of Health and the National Institute of Standards and Technology on Wednesday, Sept. 22, 2010. [Maryland Stem Cell Research Commission Press Release]


Senator Specter Introduces Fix to Stem Cell Ban
As Congress returned from recess yesterday, a long-time champion of biomedical research introduced the first proposal to override the 23 August court ruling that shut down federal funding for human embryonic stem cell for 17 days and could soon halt research again. [Congress, United States]

Appeals Court Stays Stem Cell Injunction
A federal appeals court stayed, or suspended, a preliminary injunction issued two weeks ago that brought federal funding for human embryonic stem cell research to a standstill. [Court of Appeals, United States]

NIH Rushes to Hand Out Stem Cell Grants During Temporary Stay
The National Institutes of Health (NIH) is scrambling to push out research grants for work on human embryonic stem cells (hESCs) and has given a cautious all-clear to in-house stem cell researchers after an appeals court yesterday temporarily lifted a ban on federal funding for hESC research. [National Institutes of Health, United States]

Stem Cell Research Opponents Ask Appeals Court to Reinstate Ban
In the latest development in the stem cell funding saga, the adult stem cell researchers behind the lawsuit that shut down federal funding for human embryonic stem cells three weeks ago have asked an appeals court that lifted the ban to reinstate it. [Court of Appeals, United States]

NIH Expands Network Focused on How Genes Affect Drug Responses
The National Institutes of Health plans to spend $161.3 million over the next five years to expand the Pharmacogenomics Research Network, a nationwide collaborative of scientists focused on understanding how genes affect a person’s response to medicines. [National Institutes of Health, United States]

‘Sound Science’ Code Draws Fire
The first draft policy on scientific integrity from a federal agency, released by the Department of the Interior, has drawn a storm of criticism from watchdogs including the Union of Concerned Scientists, based in Cambridge, Massachusetts. [Union of Concerned Scientists, United States]

New Animal-Research Regulations for the European Union
European scientists will use fewer animals in research when newly approved regulations come into effect across the European Union. [European Parliament, European Union]

NIH Statement Regarding Stay of Stem Cell Injunction [National Institutes of Health, United States]

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-22327) [National Institutes of Health, United States]
National Center for Research Resources; Notice of Closed Meetings (FR Doc. 2010-22529) [National Institutes of Health, United States]
National Institute of Mental Health Announces Availability of Funds for Competitive Revision Applications for a Repository Supporting Stem Cell Research Relevant to Mental Disorders (U24) (NOT-MH-10-032) [National Institutes of Health, United States]

Enhancing Peer Review:  Reminder of and Correction to Previous Notice on A2 Resubmission Opportunities for Eligible Applications (NOT-OD-10-135) [National Institutes of Health, United States]

Notice of Correction to RFA-AG-11-010, Basic Research on Self-Regulation (R21) (NOT-AG-10-011) [National Institutes of Health, United States]

Public Meeting on Animal Models–Essential Elements to Address Efficacy Under the Animal Rule; and Reopening of Comment Period (Docket No. FDA-2009-D-0007) [Food and Drug Administration, United States]


Third Annual Maryland Stem Cell Research Symposium
September 22, 2010
Gaithersburg, United States

5th Annual Meeting of the German Society for Stem Cell Research
September 30-October 2, 2010
Lübeck, Germany

5th World Congress on Preventive & Regenerative Medicine (WCRM) 2010
October 5-7, 2010
Hannover, Germany

Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine
October 7, 2010
Hertfordshire, United Kingdom

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

BioMalaysia 2010 Conference and Exhibition
November 2-4, 2010
Kuala Lumpur, Malaysia

Select Biosciences 2nd International Forum on Stem Cells
November 12-13, 2010
Tianjin, China

Stem Cell Network 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Biotech Showcase 2011
January 10-12, 2011
San Francisco, United States 

Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.



Cell Therapy Technologist (Opexa Therapeutics)

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