Volume 5.39 | Oct 6

ESC & iPSC News 5.39, October 6, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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TOP STORY

Safe, Efficient Method Reported for Creating and Differentiating Human Pluripotent Stem Cells 
Researchers report the development of a safe and efficient technology to create human induced pluripotent stem cells. [Press release from Children’s Hospital Boston discussing online prepublication in Cell Stem Cell]

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SCIENCE NEWS

University of Michigan Creates the State’s First Human Embryonic Stem Cell Line
Researchers have created the state’s first human embryonic stem cell line, known as UM4-6. [Press release from the University of Michigan discussing research presented at the World Stem Cell Summit]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA
Researchers describe a simple, nonintegrating strategy for reprogramming cell fate based on administration of synthetic mRNA modified to overcome innate antiviral responses. [Cell Stem Cell]

Efficient Differentiation of Human Pluripotent Stem Cells into Functional CD34+ Progenitor Cells by Combined Modulation of MEK/ERK and BMP4 Signaling Pathways
Results suggest that combined modulation of signaling pathways may be an efficient means of differentiating human pluripotent stem cells into functional CD34+ progenitor cells. [Blood]

Embryonic Stem Cell-Derived Hemangioblasts Remain Epigenetically Plastic and Require PRC1 to Prevent Neural Gene Expression
Researchers show that the chromatin profile of this important cohort of genes is progressively modified as embryonic stem cells differentiate towards blood-forming precursors. [Blood]

Proteome of Mouse Oocytes at Different Developmental Stages
Results provide important knowledge to better understand the molecular mechanisms in early development and may improve the generation of induced pluripotent stem cells. [Proc Natl Acad Sci U S A]

Memory in Induced Pluripotent Stem Cells: Reprogrammed Human Retinal Pigmented Epithelial Cells Show Tendency for Spontaneous Redifferentiation
Results show that retinal pigmented epithelial cells can be reprogrammed to pluripotency, and suggest that they often retain a memory of their previous state of differentiation. [Stem Cells]

Opposing Putative Roles for Canonical and Non-Canonical NFKappaB Signaling on the Survival, Proliferation and Differentiation Potential of Human Embryonic Stem Cells
The findings, coupled with opposing trends in expression of key components during human embryonic stem cell (hESC) differentiation, suggests a fine and opposing balance between the two branches of NFkappaB signaling pathways and their involvement in two distinct processes: the canonical pathway regulating hESC differentiation and the non-canonical pathway maintaining hESC pluripotency. [Stem Cells]

Cancer-Related Epigenome Changes Associated with Reprogramming to Induced Pluripotent Stem Cells
Findings suggest that by studying the process of induced reprogramming, researchers may gain significant insight into the origins of epigenetic gene silencing associated with human tumorigenesis, and add to means of assessing induced pluripotent stem cells for safety. [Cancer Res]

Efficacy of hESC-MSCs in Knitted Silk-Collagen Scaffold for Tendon Tissue Engineering and Their Roles
Tissue-engineered tendon can be successfully fabricated through seeding of human embryonic stem cell-derived mesenchymal stem cells (hESC-MSCs) within a knitted silk-collagen sponge scaffold followed by mechanical stimulation. [Biomaterials]

Rhythmic Beating of Stem Cell-Derived Cardiac Cells Requires Dynamic Coupling of Electrophysiology and Ca Cycling
Rhythmic embryonic stem cell-derived cardiocyte automaticity can be achieved by boosting “coupling” factors, such as cAMP/PKA signaling, that enhance interactions between sarcoplasmic reticulum and sarcolemma. [J Mol Cell Cardiol]

A Novel Stepwise Differentiation of Functional Pancreatic Exocrine Cells from Embryonic Stem Cells
Researchers developed a differentiation protocol that gradually induced the formation of mouse pancreatic exocrine cells from embryonic stem cells. [Stem Cells Dev]

INDUSTRY NEWS

Oakland University and Beaumont Announce Stem Cell Research Partnership
With the Oakland University William Beaumont School of Medicine set to open with its inaugural class in fall 2011, its parent institutions have launched the Oakland University William Beaumont Institute for Stem Cell and Regenerative Medicine. [Beaumont Hospitals Press Release]

McLean Researchers Awarded $1.9 Million Grant for Stem Cell, Blood Research
Researchers at Harvard-Affiliated McLean Hospital have been awarded a $1.9 million National Institutes of Health Director’s Opportunity Award to continue their research into creating human induced pluripotent stem cells using a method aimed at eliminating the risk of cancer and other problems associated with other options such as genome-integrating viral methods. [McLean Hospital Press Release]

Quicken Founder Gilbert Invests in Stem Cell Research
Gilbert, founder and chairman of Quicken Loans Inc., told the audience at the World Stem Cell Summit in Detroit that he supports stem cell research and has invested several million dollars in Cellerant Therapeutics, a California-based company. [The Detroit News]

POLICY NEWS

Appeals Court Says Stem Cell Funding Can Continue
An appeals court decided to allow federal funding for human embryonic stem cell (hESC) research to continue while the court considers legal arguments that halted hESC research last month. [Court of Appeals, United States]

Court Schedule Suggests Stem Cell Lawsuit Won’t Be Resolved Until Late in Year
The court dates for the lawsuit tying up stem cell research suggest the case won’t be decided until at least Thanksgiving and could take until the end of the year. [Court of Appeals, United States]

Lawmakers Introduce Bipartisan Legislation to Create Jobs and Promote Investment in Life Sciences
U.S. Representatives introduced bipartisan legislation that will provide tax incentives for small and mid-sized businesses to invest in life sciences research and development on a targeted basis. The Life Sciences Jobs and Investment Act of 2010 provides an opportunity to enhance medical innovation, life sciences education and job creation in the United States. [House of Representatives, United States]

NIH and FDA Announce Awards to Advance Regulatory Science
The National Institutes of Health will award $9.4 million over three years to support four research projects in regulatory science. This research is conducted in partnership with the U.S. Food and Drug Administration, which will contribute approximately $950,000. [National Institutes of Health and Food and Drug Administration, United States]

FDA Issues Final Rule on Safety Information During Clinical Trials
The U.S. Food and Drug Administration (FDA) issued a final rule that clarifies what safety information must be reported during clinical trials of investigational drugs and biologics. [Food and Drug Administration, United States]

NIH Transformative Research Project Awards Hasten Innovation
The National Institutes of Health will award up to $64 million over five years to encourage exploration of exceptionally innovative and original research ideas that have the potential for extraordinary impact. [National Institutes of Health, United States]

Clarification of the Submission Date for Applications for Program Projects for Collaborative Research on the Basic Biology of Pluripotency and Reprogramming (P01) (RFA-GM-11-005) (NOT-GM-10-109) [National Institute of General Medical Sciences, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24680) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24549) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-24550) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-24556) [National Institutes of Health, United States]
 
Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-24405) [National Institutes of Health, United States] 

EVENTS

Induced Pluripotent Stem Cells: Production and Utility in Regenerative Medicine
October 7, 2010
Welwyn Garden City, United Kingdom

Functional Stem Cell and Regeneration
October 9-10, 2010
Kansas City, United States

18th Annual BioPartnering Europe
October 10-12, 2010
London, United Kingdom

3rd Biobridge “Generation Regeneration” Conference
October 11, 2010
Geneva, Switzerland

New York Stem Cell Foundation 5th Annual Translational Stem Cell Research Conference
October 12-13, 2010
New York City, United States

4th International Symposium Stem Cells, Development and Regulation
October 12-14, 2010
Amsterdam, Netherlands

Stem Cells and Regenerative Medicine – New Solutions to Old Problems
October 18-20, 2010
San Antonio, United States

European Society of Gene and Cell Therapy (ESGCT) 18th Annual Congress
October 22-25, 2010
Milan, Italy

World Stem Cells & Regenerative Medicine Congress Asia 2010
October 26-28, 2010
Seoul, Korea

Fraunhofer Life Science Symposium Leipzig 2010
October 29-30, 2010
Leipzig, Germany

Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
November 2-3, 2010
Singapore

BioMalaysia 2010 Conference and Exhibition
November 1-3, 2010
Kuala Lumpur, Malaysia

Select Biosciences 2nd International Forum on Stem Cells (2010 IFSC)
November 12-13, 2010
Tianjin, China

The 16th International Conference of the International Society of Differentiation: From Stem Cells to Organisms
November 15-18, 2010
Nara, Japan

8th Annual Commercial Translation of Regenerative Medicine Conference
November 18-19, 2010
London, United Kingdom

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Alberta

Tissue Engineering & Regenerative Medicine International Society – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Biotech Showcase 2011
January 10-12, 2011
San Francisco, USA

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

Keystone Symposia-Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Molecular Medicine Tri-Conference – Stem Cells: Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Stem Cells, Cancer and Metastasis (C4)
March 6-11, 2011
Dillon, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

 



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