Volume 5.45 | Nov 17

ESC & iPSC News 5.45, November 17, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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TOP STORY

Embryonic Stem Cell Culturing Grows from Art to Science 
A team of researchers reports the development of a fully defined culture system that promises a more uniform and, for cells destined for therapy, safer product. [Press release from the University of Wisconsin-Madison discussing online prepublication in Nature Methods]

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SCIENCE NEWS

Modeling Autism in a Dish
Researchers successfully used human induced pluripotent stem cells derived from patients with Rett syndrome to replicate autism in the lab and study the molecular pathogenesis of the disease. [Press release from the Salk Institute for Biological Studies discussing online prepublication in Cell]
 
Stem Cell Patch May Result in Improved Function Following Heart Attack
Researchers have found that applying a stem cell-infused patch together with overexpression of a specific cell instruction molecule promoted cell migration to damaged cardiac tissue following heart attack and resulted in improved function in animal models. [Press release from the University of Cincinnati discussing research presents at the American Heart Association Scientific Sessions 2010]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

A Model for Neural Development and Treatment of Rett Syndrome Using Human Induced Pluripotent Stem Cells
Using Rett syndrome (RTT) as an autism spectrum disorders genetic model, researchers developed a culture system using induced pluripotent stem cells from RTT patients’ fibroblasts. [Cell]
 
A Defined Glycosaminoglycan-Binding Substratum for Human Pluripotent Stem Cells
Results indicate that synthetic substrates that recognize cell-surface glycans can facilitate the long-term culture of pluripotent stem cells. [Nat Methods]

Caveolin-1 and Integrin Beta1 Regulate Embryonic Stem Cell Proliferation via p38 MAPK and FAK in High Glucose
Results demonstrate that high glucose-induced caveolin-1 and integrin beta1 activation can stimulate embryonic stem cell proliferation through the modification of focal adhesion signaling pathways. [J Cell Physiol]
 
Reprogramming of Telomeric Regions During the Generation of Human Induced Pluripotent Stem Cells and Subsequent Differentiation into Fibroblast-Like Derivatives
Researchers studied telomere length, subtelomeric DNA methylation and telomeric-repeat-containing RNA expression in several human induced pluripotent stem cell clones derived from normal neonatal foreskin fibroblasts. [Epigenetics]

Spontaneous In Vivo Differentiation of Embryonic Stem Cell-Derived Pancreatic Endoderm-Like Cells Corrects Hyperglycemia in Diabetic Mice
Data suggest that Pdx1-expressing pancreatic endoderm-like cells are capable of spontaneously undergoing differentiation in vivo into insulin-producing cells and leading to a sustained correction of hyperglycemia in diabetic mice. [Transplantation]
 
Analysis of Co-Expression of OCT4, NANOG and SOX2 in Pluripotent Cells of the Porcine Embryo, In Vivo and In Vitro
Researchers studied the spatial and temporal expression pattern of key factors in pluripotency and lineage segregation of blastocyst-stage porcine embryos between embryonic days (E) 6.5 and E10.5. [Theriogenology]

Core Transcription Factors, Oct4, Sox2 and Nanog, Individually Form Complexes with Nucleophosmin (Npm1) to Control Embryonic Stem (ES) Cell Fate Determination
Researchers described four novel protein-protein interactions in ES cell involving all three core transcription factors. [Aging]

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INDUSTRY NEWS

Verastem Secures $16 Million in Series A Financing for Novel Cancer Stem Cell Drugs
Verastem, Inc. announced the closing of a $16 million Series A financing. Founding investor, Longwood Founders Fund, was joined by Bessemer Venture Partners, Cardinal Partners, and MPM Capital. [Enhanced Online News]
 
ReNeuron Announces First Patient Treated in Landmark Stroke Stem Cell Clinical Trial
ReNeuron Group plc announced that the first patient has been treated with the Company’s ReN001 stem cell therapy for stroke in a ground-breaking UK clinical trial. [ReNeuron Group Press Release]
 
Dr. Shinya Yamanaka Receives 2010 Kyoto Prize in “Advanced Technology” for Work with Induced Pluripotent
The non-profit Inamori Foundation (President: Dr. Kazuo Inamori) presented Dr. Shinya Yamanaka with its 26th annual Kyoto Prize in Advanced Technology, which focuses for 2010 on the fields of Biotechnology and Medical Technology. [Kyoto Symposium Organization Press Release]

POLICY NEWS

New Stem Cell Action Coalition Launches Campaign Supporting Embryonic Stem Cell Research
The Genetics Policy Institute announced the launch of a new advocacy coalition of 30 organizations to foster public awareness and advance the cause of embryonic stem cell research in the United States. [Stem Cell Action Coalition, United States]
 
FDA Seen Tougher on Drug Risks Post-Avandia
Regulators appear to be increasing their scrutiny of product risks after cases like the bitter debate over the diabetes pill Avandia, industry executives and experts said. [Food and Drug Administration, United States]
 
European Medicines Agency and Massachusetts Institute of Technology Launch Joint Project on Regulatory Science
The European Medicines Agency and the Massachusetts Institute of Technology’s Center for Biomedical Innovation and Center for International Studies are launching a collaborative research project with a focus on enhancing regulatory science in pharmaceuticals. [European Medicines Agency, European Union]

Establishment of the Independence Advisory Council (FR Doc. 2010-28781) [Department of Health and Human Services, United States]
 
Institutional Clinical and Translational Science Award (U54) (RFA-RM-10-020) [National Institutes of Health, United States]
 
Office of the Director, Office of Biotechnology Activities; Notice of Meeting (FR Doc. 2010-28373) [National Institutes of Health, United States]
 
Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-28467) [National Institutes of Health, United States]
 
Government-Owned Inventions; Availability for Licensing (FR Doc. 2010-27912) [National Institutes of Health, United States]

EVENTS

8th Annual Commercial Translation of Regenerative Medicine Conference
November 18-19, 2010
London, United Kingdom

Stem Cell Network’s 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

NEW The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Biotech Showcase 2011
January 10-12, 2011
San Francisco, United States

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

NEW Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

Molecular Medicine Tri-Conference: Stem Cells – Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Stem Cells, Cancer and Metastasis
March 6-11, 2011
Dillon, United States

NEW 15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

NEW StemCONN 11
March 22, 2011
Farmington, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

NEW Clinical Gene Transfer: State of the Art Conference and e-Chips European Congress on Human iPS Cells
April 7-9, 2011
Paris, France

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

 



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