Volume 5.48 | Dec 8

ESC & iPSC News 5.48, December 8, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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TOP STORY

Scientists Home In on Chemicals Needed to Reprogram Cells 
Scientists have made a significant leap forward in the drive to find a way to safely reprogram mature human cells and turn them into stem cells, which can then change into other cell types, such as nerve, heart, and liver cells. [Press release from The Scripps Research Institute discussing online prepublication in Cell Stem Cell]

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SCIENCE NEWS

Reproductive Scientists Create Mice from Two Fathers
Using stem cell technology, reproductive scientists at the M.D. Anderson Cancer Center have produced male and female mice from two fathers. [Press release from EurekAlert! discussing online prepublication in Biology of Reproduction]

Japan Team Say Stem Cells Helped Monkey Jump Again
Japanese researchers said they had used stem cells to restore partial mobility in a small monkey that had been paralyzed from the neck down by a spinal injury. [Associated Free Press]

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CURRENT PUBLICATIONS  (Ranked by Impact Factor of the Journal)

Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds
Researchers report a small molecule cocktail that enables reprogramming of human primary somatic cells to induced pluripotent stem cells with exogenous expression of only OCT4. [Cell Stem Cell]
 
MicroRNA Profiling Reveals Two Distinct p53-Related Human Pluripotent Stem Cell States
Researchers profiled miRNA expression levels across 49 human cell lines, including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), differentiated cells, and cancer cell lines. They found that the resulting miRNA profiles divided the iPSCs and human ESCs examined into two distinct categories irrespective of the cell line origin. [Cell Stem Cell]
 
A Mesoderm-Derived Precursor for Mesenchymal Stem and Endothelial Cells
Using human embryonic stem cells directed toward mesendodermal differentiation, researchers show that mesenchymal stem/stromal cells originate from a population of mesodermal cells identified by expression of apelin receptor. [Cell Stem Cell]
 
A Cyclic AMP Analog, 8-Br-cAMP, Enhances the Induction of Pluripotency in Human Fibroblast Cells
Researchers demonstrate that 8-Bromoadenosine 3′, 5′-cyclic monophosphate improves the reprogramming efficiency of human neonatal foreskin fibroblast cells transduced with the four transcription factors by two-fold. [Stem Cell Rev]
 
Murine Embryonic Stem Cells Self Renewal and Pluripotency Is Maintained by a Bovine Granulosa Cell Line Conditioned Medium While Increasing the Proliferation Rate
Researchers studied the effects of the conditioned medium from a bovine granulosa cell line (BGC-CM), on the maintenance of self renewal and pluripotency of murine embryonic stem cells (mESCs). They found that this medium is able to maintain mESC self renewal while preserving its critical properties without leukemia inhibitory factor addition. [Stem Cells Dev]
 
Human Germ Cell Differentiation from Fetal- and Adult-Derived Induced Pluripotent Stem Cells
Researchers compared the potential of human induced pluripotent stem cells, derived from adult and fetal somatic cells, to form primordial and meiotic germ cells, relative to human embryonic stem cells. [Hum Mol Genet]
 
Successful Differentiation to T Cells, But Unsuccessful B-Cell Generation, from B-Cell-Derived Induced Pluripotent Stem Cells
Forced expression of certain transcription factors in somatic cells results in generation of induced pluripotent stem (iPS) cells, which differentiate into various cell types. Researchers investigated T-cell and B-cell lineage differentiation from iPS cells in vitro. [Int Immunol]

Generation of Viable Male and Female Mice from Two Fathers
Researchers used pluripotent stem cells derived from somatic cells to combine the haploid genomes from two males to produce viable sons and daughters. [Biol Reprod]
 
There Is More to a Lipid Than Just Being a Fat: Sphingolipid-Guided Differentiation of Oligodendroglial Lineage from Embryonic Stem Cells
Research showed for the first time that the composition of glycosphingolipids is tightly regulated during embryo development. The new studies suggest that ceramide and its derivative, sphingosine-1-phosphate, act synergistically on embryonic stem cell differentiation. [Neurochem Res]


INDUSTRY NEWS

Wellcome Trust Award Could Bring Sight for Sore Eyes
A collaboration between scientists at the University of Sheffield and the LV Prasad Eye Institute in Hyderabad, India recently received an award under the new R&D for Affordable Healthcare in India scheme — a partnership between the Indian government’s Department of Biotechnology and the Wellcome Trust — to support development of a stem cell-based therapy to restore sight in eyes where the cornea has been damaged by chemical injury or burns. [Wellcome Trust Press Release]
 
Mesoblast and Cephalon Enter into Strategic Alliance to Commercialize Novel Therapeutic Products for Regenerative Medicine
Regenerative medicine company, Mesoblast Limited and global biopharmaceutical company, Cephalon, Inc., announced they have entered into a strategic alliance to develop and commercialize novel adult stem cell therapeutics for degenerative conditions of the central nervous and cardiovascular systems. [Mesoblast Limited Press Release]
 
State Receives $16 Million for Biomedical Research
Ten colleges and universities in the state, including the University of South Carolina, have received $16 million to support a network to develop biomedical-research programs in areas such as regenerative medicine, biochemistry and molecular biology. [University of South Carolina Press Release]

Robert Klein Reacts to Nomination to Second Term as Chair of CIRM Independent Citizens’ Oversight Committee
Robert N. Klein, author of Proposition 71 and Chairman of the Independent Citizens Oversight Committee, which oversees the California Institute for Regenerative Medicine (CIRM), reacted to his nomination by Governor Schwarzenegger and Lieutenant Governor Maldonado to a second term as Chair. [California Institute for Regenerative Medicine Press Release]

New International Competition Focuses on Early Career Scientists
The Howard Hughes Medical Institute launched an international competition to select up to 35 early career scientists working at academic institutions in 18 countries on five continents with the goal of helping these talented individuals establish independent research programs. [Howard Hughes Medical Institute Press Release]

POLICY NEWS

Stem Cell Funding Has Day in Court
Three federal appeals judges questioned lawyers on both sides of the lawsuit over whether federally funded research on human embryonic stem cells is illegal. [Court of Appeals, United States]

NIH Considering New Translational Medicine Institute
Weeks after deciding to trim one of its 27 institutes and centers, the National Institutes of Health is now looking at creating a new center focused on translational medicine. [National Institutes of Health, United States]

NHS Blood and Transplant and Anthony Nolan Welcome Publication of Stem Cell Strategy Report
NHS Blood and Transplant and charity Anthony Nolan welcomed the publication of a new report setting out recommendations to save 200 patient lives a year by improving the availability and quality of stem cell transplants in the UK. [National Health Service, United Kingdom]
 
European Medicines Agency Widens Public Access to Documents
The European Medicines Agency has published its new policy on access to documents related to medicines for human and veterinary use. [European Medicines Agency, European Union]

National Institute of Biomedical Imaging and Bioengineering; Notice of Meeting (FR Doc. 2010-30644) [National Institutes of Health, United States]
 
National Cancer Institute; Notice of Meeting (FR Doc. 2010-30456) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-30458) [National Institutes of Health, United States]
 
Center For Scientific Review; Notice of Closed Meetings (FR Doc. 2010-30455) [National Institutes of Health, United States]
 
New Page Limits for NIH Individual Career Development (K) Award Applications: Due Dates After January 7, 2011 (NOT-OD-11-027) [National Institutes of Health, United States]

2010 Biological License Application Supplement Noteworthy Approvals [Center for Biologics Evaluation and Research, United States]

EVENTS

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America (TERMIS-NA) 2010 Annual Conference
December 5-8, 2010
Orlando, United States

5th Annual Stem Cell Meeting on the Mesa
December 7, 2010
La Jolla, United States

The 3rd Young Investigator Stem Cell Meeting
December 14, 2010
Tel Aviv, Israel

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Biotech Showcase 2011
January 10-12, 2011
San Francisco, United States

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

SMi Stem Cells 2011 – Innovation and Commercialisation
February 23-24, 2011
London, United Kingdom

Molecular Medicine Tri-Conference: Stem Cells – Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Stem Cells, Cancer and Metastasis
March 6-11, 2011
Dillon, United States

PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

StemCONN 11
March 22, 2011
Farmington, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

Clinical Gene Transfer: State of the Art Conference and e-Chips European Congress on Human iPS Cells
April 7-9, 2011
Paris, France

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States

13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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