Volume 5.49 | Dec 15

ESC & iPSC News 5.49, December 15, 2010.
In this issue:  Science News |  Current Publications |  Industry News |  Policy News |  Events
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TOP STORY

Stem Cells Turned Into Complex, Functioning Intestinal Tissue in Lab 
For the first time, scientists have created functioning human intestinal tissue in the laboratory from pluripotent stem cells. [Press release from Cincinnati Children’s Hospital Medical Center discussing online prepublication in Nature]

Defining Characteristics of Bona Fide Human iPS Cells
Speaker: Sutheera Ratanasirintrawoot, PhD Candidate
G. Daley & T. Schlaeger Labs, Harvard Medical School
WEBINAR: VIEW HERE STEMCELL Technologies Inc


SPECIAL FEATURE

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SCIENCE NEWS

“Grow Your Own Transplant” May be Possible for Men with Type 1 Diabetes
Men with type 1 diabetes may be able to grow their own insulin-producing cells from their testicular tissue, say researchers. [Press release from Georgetown University Medical Center discussing research presented at American Society of Cell Biology 50th Annual Meeting]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Directed Differentiation of Human Pluripotent Stem Cells Into Intestinal Tissue In Vitro
Researchers establish a robust and efficient process to direct the differentiation of human pluripotent stem cells into intestinal tissue in vitro using a temporal series of growth factor manipulations to mimic embryonic intestinal development. [Nature]
 
Genomic Safe Harbors Permit High Beta-Globin Transgene Expression in Thalassemia Induced Pluripotent Stem Cells
Researchers describe a strategy to genetically modify human induced pluripotent stem cells at ‘safe harbor’ sites in the genome, which fulfill five criteria based on their position relative to contiguous coding genes, microRNAs and ultraconserved regions. [Nat Biotechnol]

Tracking and Assessing the Rise of State-Funded Stem Cell Research
In the eight-year period preceding the most recent NIH guidelines, only a small number of cell lines could be studied with federal funds. During this time, six states — California, Connecticut, Illinois, Maryland, New Jersey and New York — took on a role typically played by the NIH and created funding programs specifically designed to support stem cell research, including human embryonic stem cell research. [Nat Biotechnol]

LIF-Independent JAK Signaling to Chromatin in Embryonic Stem Cells Uncovered From an Adult Stem Cell Disease
Researchers show that mouse embryonic stem cells carrying the human JAK2V617F mutation were able to self-renew in chemically defined conditions without cytokines or small-molecule inhibitors, independently of JAK signaling through the STAT3 or phosphatidylinositol-3-OH kinase pathways. [Nat Cell Biol]
 
Monocytic Cells Derived From Human Embryonic Stem Cells and Fetal Liver Share Common Differentiation Pathways and Homeostatic Functions
Researchers show that monocytic cells derived from human embryonic stem cells and fetal liver follow a differentiation pathway different to that of adult cells, leading to specific functions. [Blood]
 
Switching of the Core Structures of Glycosphingolipids From Globo- and Lacto- to Ganglio-Series Upon Human Embryonic Stem Cell Differentiation
In addition to the well-known human embryonic stem cell (hESC)-specific markers stage-specific embryonic antigen 3 (SSEA-3) and SSEA-4, researchers identified several globosides and lacto-series glycosphingolipids, previously unrevealed in hESCs, including Gb4Cer, Lc4Cer, fucosyl Lc4Cer, Globo H, and disialyl Gb5Cer. [Proc Natl Acad Sci U S A]

A Regulatory Circuitry Comprised of miR-302 and the Transcription Factors OCT4 and NR2F2 Regulates Human Embryonic Stem Cell Differentiation
Researchers show that the transcriptional factors OCT4 and NR2F2 (COUP-TFII) and the miRNA miR-302 are linked in a regulatory circuitry that critically regulate both pluripotency and differentiation in human embryonic stem cells. [EMBO J]

Large-Scale Phosphoproteome Profiles Comprehensive Features of Mouse Embryonic Stem Cells
This work provides an overview of phosphorylation in mouse embryonic stem (mES) cells and is a valuable resource for the future understanding of basic biology in mES cells. [Mol Cell Proteomics]
 
Choice of Random Rather Than Imprinted X Inactivation in Female Embryonic Stem Cell-Derived Extra-Embryonic Cells
Researchers tested the mode of X inactivation during the differentiation of female mouse embryonic stem cells derived from the inner cell mass of blastocyst-stage embryos toward trophectoderm and primitive endoderm lineages induced by artificial activation of transcription factor genes Cdx2 and Gata6, respectively. [Development]

Generation of HIV-1 Resistant and Functional Macrophages from Hematopoietic Stem Cell-Derived Induced Pluripotent Stem Cells
Researchers demonstrate the ability of induced pluripotent stem cells (iPSCs) to develop into HIV-1 resistant immune cells and highlight the potential use of iPSCs for HIV gene and cellular therapies. [Mol Ther]
 
Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage
Researchers report the in vitro differentiation of mouse induced pluripotent stem cells into a keratinocyte lineage through sequential applications of retinoic acid and bone-morphogenetic protein-4 and growth on collagen IV-coated plates. [J Invest Dermatol]
 
Influencing Hematopoietic Differentiation of Mouse Embryonic Stem Cells Using Soluble Heparin and Heparan Sulfate Saccharides
Embryonic stem cells (ESCs) derived from Ext1-/- embryos are unable to differentiate into hematopoietic lineages, instead retaining ESC marker expression throughout embryoid body culture. However hematopoietic differentiation can be restored by the addition of soluble heparin. [J Biol Chem]


INDUSTRY NEWS

States Now Fund Majority of Human Embryonic Stem Cell Research
States, not the federal government, now fund the majority of human embryonic stem cell research conducted in the United States, according to a recent study. [Press release from the Georgia Institute of Technology discussing online prepublication in Nature Biotechnology]

Melbourne Receives $21 Million for Pioneering Stem Cell Research
The University of Melbourne has been awarded $21 million from the Australian Research Council to establish Stem Cells Australia, an initiative that will position Australia as a major world player in stem cell research. [University of Melbourne Press Release]

University of Toronto-Hosted Project to Develop Regenerative Medicine Products Is Awarded $15 Million From the Federal Government
A University of Toronto-hosted project to develop products to treat devastating health conditions such as heart disease, diabetes, cancer and spinal cord injuries, The Centre for Commercialization of Regenerative Medicine, has been awarded $15 million by the federal government. [University of Toronto Press Release]

$26 Million Boosts Stem Cell Research
A new $26.5-million stem cell research facility to be built at the University of Alberta will keep Edmonton at the forefront of regenerative medicine for patients with diabetes, burns, premature lungs and Parkinson’s disease. [The Edmonton Journal]

ReNeuron Announces Fundraising
ReNeuron Group plc announced that it has raised £10 million, before expenses. [ReNeuron Group plc Press Release]
 
Harvard Bioscience Files Two Major Patents in Field of Regenerative Medicine
Harvard Bioscience, Inc. has filed two major patents in the field of regenerative medicine, the first covering 61 claims for its stem cell therapy injectors and the second for 338 claims for bioreactors for organ growth. [Harvard Bioscience, Inc. Press Release]

Sanofi-aventis Appoints Dr. Elias Zerhouni, President, Global Research & Development
Sanofi-aventis announced the appointment of Dr. Elias Zerhouni as President, Global Research & Development, covering Medicines and Vaccines, effective January 1, 2011. [Sanofi-aventis Press Release]


POLICY NEWS

NIH Panel Approves More Stem Cell Lines
A key advisory panel to the National Institutes of Health (NIH) director has recommended that four additional human embryonic stem cell lines be added to those eligible for U.S. funding. [National Institutes of Health, United States]
 
House Approves Flat 2011 Budget for Most Science Agencies
The three federal agencies that support the vast majority of academic research would receive no more money in 2011 than in 2010 under a spending bill that narrowly passed the House of Representatives. [House of Representatives, United States]
 
CIRM-MRC Human Somatic Cell Nuclear Transfer Workshop Report
Report of an Medical Research Council (MRC) and California Institute for Regenerative Medicine (CIRM) workshop to examine human somatic cell nuclear transfer and its role in stem cell research, summarizing the state of the global research effort in this area. [Medical Research Council, United Kingdom]
 
Public Consultation on Personnel Reliability and Culture of Responsibility Issues (FR Doc. 2010-31056) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-31058) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-31057) [National Institutes of Health, United States]
 
Center for Scientific Review; Notice of Closed Meeting (FR Doc. 2010-31054) [National Institutes of Health, United States]
 
Guidance for the Public, FDA Advisory Committee Members, and FDA Staff: The Open Public Hearing at FDA Advisory Committee Meetings; Availability [Docket No. FDA-2005-D-0072] (formerly Docket No. 2005D-0042) [Food and Drug Administration, United States]


EVENTS

Pharmacology in Stem Cells Research and Regenerative Medicine
December 17, 2010
London, United Kingdom

The 3rd Guangzhou International Conference on Stem Cell Biology and Regenerative Medicine
December 17-19, 2010
Guangzhou, China

Biotech Showcase 2011
January 10-12, 2011
San Francisco, United States

5th Annual Stem Cells and Regenerative Medicine World Congress
January 24-25, 2011
San Diego, United States

Keystone Symposia: Stem Cells in Development, Tissue Homeostasis and Disease
January 30-February 4, 2011
Santa Fe, United States

Stem Cell Research Forum of India 2nd Annual Meeting
February 8-11, 2011
Bangalore, India

SMi Stem Cells 2011 – Innovation and Commercialisation
February 23-24, 2011
London, United Kingdom

Molecular Medicine Tri-Conference: Stem Cells – Revolutionizing Regenerative Medicine and Personalized Therapy 2011
February 23-25, 2011
San Francisco, United States

Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
February 28-March 2, 2011
Munich, Germany

6th Annual Stem Cell Summit
March 1, 2011
New York, United States

American Association for Cancer Research (AACR) Stem Cells, Development, and Cancer
March 3-6, 2011
Vancouver, Canada

Keystone Symposia: Stem Cells, Cancer and Metastasis
March 6-11, 2011
Dillon, United States

PITTCON Conference & Expo 2011
March 13-18, 2011
Atlanta, United States

15th Annual Hilton Head Workshop – Regenerative Medicine, Innovations for Clinical Applications
March 16-19, 2011
Hilton Head Island, United States

StemCONN 11
March 22, 2011
Farmington, United States

United Kingdom National Stem Cell Network 2011 Annual Scientific Conference
March 30-April 1, 2011
York, United Kingdom

Clinical Gene Transfer: State of the Art Conference and e-Chips European Congress on Human iPS Cells
April 7-9, 2011
Paris, France

World Stem Cells & Regenerative Medicine Congress 2011
May 9-11, 2011
London, United Kingdom

American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States

13th Annual C21 BioVentures
May 24-26, 2011
Napa, United States

NEW Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Europe 2010 Annual Conference
June 7-10, 2011
Granada, Spain

NEW International Society for Stem Cell Research (ISSCR) 9th Annual Meeting
June 15-18, 2011
Toronto, Canada

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


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