Volume 6.18 | May 11

ESC & iPSC News 6.18, May 11, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORIES

Genome-Wide Mapping of 5-Hydroxymethylcytosine in Embryonic Stem Cells
Scientists describe two novel and specific approaches to profile the genomic localization of 5-hydroxymethylcytosine. [Nature]

CIRM Awards $25 Million to Support Spinal Cord Injury Trial, $37.7 Million for Basic Stem Cell Science
The Governing Board of the California Institute for Regenerative Medicine (CIRM) approved a $25 million award to support the first FDA-approved clinical trial based on cells derived from human embryonic stem cells. The award to Menlo Park-based Geron, Corp, will support the company’s on-going early phase trial for people with spinal cord injury. [California Institute for Regenerative Medicine Press Release]

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SCIENCE NEWS

What Decides Neural Stem Cell Fate?
A team recently found that expression of a gene called SOX2 maintains the potential for neural crest stem cells to become neurons in the peripheral nervous system, where they interface with muscles and other organs. [Press release from Sanford-Burnham Medical Research Institute discussing online prepublication in Cell Stem Cell]

Heart Cells Derived from Stem Cells Used to Study Heart Diseases
A research team is the first to use heart cells derived from stem cells to specifically study certain genetic mechanisms of heart diseases. [Press release from the University of Wisconsin School of Medicine and Public Health discussing research presented at the Annual Heart Rhythm Society Meeting]

Stem Cell Technology Used in Unique Surgery
For the first time ever in the world, researchers have produced a blood vessel from stem cells and then used it in an operation on a 10-year-old girl. [University of Gothenburg Press Release]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Human ESC-Derived Neural Crest Model Reveals a Key Role for SOX2 in Sensory Neurogenesis
Data suggest that SOX2 plays a key role for NGN1-dependent acquisition of neuronal fates in sensory ganglia. [Cell Stem Cell]

Generation of Keratinocytes from Normal and Recessive Dystrophic Epidermolysis Bullosa-Induced Pluripotent Stem Cells
Studies indicate that autologous induced pluripotent stem cells have the potential to provide a source of cells for regenerative therapies for specific skin diseases. [Proc Natl Acad Sci U S A]

Efficient Generation of Hematopoietic Precursors and Progenitors From Human Pluripotent Stem Cell Lines
By mimicking embryonic development of the hematopoietic system, researchers have developed an optimized in vitro differentiation protocol for the generation of precursors of hematopoietic lineages and primitive hematopoietic cells from human embryonic stem cells and induced pluripotent stem cells. [Stem Cells]

Tissue-Specific Demethylation in CpG-Poor Promoters During Cellular Differentiation
Investigators comprehensively studied methylation levels of 27 578 CpG sites among 21 human normal tissues from 12 anatomically different regions using an epigenotyping bead array system. [Hum Mol Genet]


iPS Cells Repair and Regenerate Infarcted Myocardium
Scientists transduced H9c2 cells with four stemness factors; Oct3/4, Sox2, Klf4, and c-Myc, and successfully reprogrammed them into iPS cells. [Mol Pharm]

L-Threonine Regulates G1/S Phase Transition of Mouse Embryonic Stem Cells Via PI3K/Akt, MAPKs, and mTORC Pathways
Researchers investigated the effect of L-threonine on regulation of mouse embryonic stem cell self-renewal and related signaling pathways. [J Biol Chem]

AW551984: A Novel Regulator of Cardiomyogenesis from Pluripotent Embryonic Cells
Investigators identified genes that modulate the cardiac differentiation of pluripotent embryonic cells. [Biochem J]

Polycomb Group Protein Bmi1 Promotes Hematopoietic Cell Development from ES Cells
To assess the role of Bmi1 in pluripotent stem cells and upon exit from pluripotency during differentiation, scientists studied forced Bmi1 expression in mouse embryonic stem cells. [Stem Cells Dev]

INDUSTRY NEWS

Stem Cell Standardization Deal Inked Between New Players Sistemic and Leaders Roslin Cells
Sistemic Ltd. and Roslin Cells Ltd. signed a Memorandum of Understanding to promote the development of new technologies for the standardization of the manufacture of stem cells for their use in cell therapy and drug development screening. [Sistemic Ltd. Press Release]

UCSF Stem Cell Studies to Focus on Muscular Dystrophy, Heart Disease, Cancer
Three University of California, San Francisco (UCSF) scientists have received grants from the California Institute for Regenerative Medicine to advance their investigations of treatment strategies for degenerative muscle diseases, such as muscular dystrophy, and heart disease, and to determine why human embryonic stem cells are susceptible to forming tumors. [University of California, San Francisco Press Release]

Nation’s Second Participant Enrolls in Human Embryonic Stem Cell Trial
Researchers at Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine and The Rehabilitation Institute of Chicago recently enrolled their first subject in a national clinical research trial of a human embryonic stem cell-based therapy for participants with a subacute thoracic spinal cord injury. This is only the second enrollment nationwide in the study sponsored by Geron Corp. [Northwestern Memorial Hospital Press Release]

POLICY NEWS

More Briefs Coming in Stem Cell Lawsuit
After months of inactivity, a lawsuit challenging the legality of National Institutes of Health funding for human embryonic stem cell research could soon be moving again. Lawyers for the plaintiffs in Sherley v. Sebelius asked U.S. District Judge Royce Lamberth to allow both sides to respond to a 29 April decision from a federal appeals court. [U.S. Federal Appeals Court, United States]

Holdren’s Response to Ban on China Science Partnerships Draws GOP Ire
The Obama Administration has carved out a loophole in the recent congressional ban on scientific interactions with China that would permit most activities between the two countries to continue. But that interpretation doesn’t sit well with Republicans in the House of Representatives who drafted the language, one of whom said that ignoring the ban could imperil funding for NASA or other science agencies. [House of Representatives, United States]

European Science Foundation Members Fumble Merger Plans
The long-planned creation of a new body to speak for European science was thrown into disarray at a special general assembly of the European Science Foundation when its member organizations backed away from proposals to merge with EuroHORCs, an informal body that now represents Europe’s national funding agencies.  [European Science Foundation, France]

Russia Pledges $4 Billion for Pharma-2020 Plan
Speaking at the opening of a new birth center in Ryazan on 11 March, Prime Minister Vladimir Putin stated that the government wants to boost Russia’s presence on the world biopharma stage to 3–5% in the next decade. [Russian Government, Russia]

Office of the Director, National Institutes of Health; Notice of Closed Meeting (FR Doc. 2011-10667) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2011-10670) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2011-10675) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2011-10731) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2011-10733) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2011-10749) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2011-11033) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc No: 2011-11176) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc No: 2011-11177) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2011-10742) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2011-11031) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc No: 2011-11204) [National Institutes of Health, United States]

Advisory Committee; Medical Imaging Drugs Advisory Committee; Reestablishment [FR Doc. 2011-10813] [Food and Drug Administration, United States]

Science Board Advisory Committee; Notice of Meeting [Docket No. FDA-2011-N-0002] [Food and Drug Administration, United States]

EVENTS
NEW 70th Annual Meeting of the Society for Developmental Biology
July 21-25, 2011
Chicago, United States

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Postdoctoral Research Fellow (University of Ottawa)

Senior Postdoctoral Fellow (New York Stem Cell Foundation)

Postdoc in Human Embryonic Stem Cell Bioprocessing (School of Biotechnology at the Royal Institute of Technology)

Postdoctoral Position in Stem Cells and Epigenetics (Mount Sinai School of Medicine)

Stem Cell Biologist (Pfizer)

Postdoctoral Fellow (Stanford University)

Senior Postdoctoral Fellow (New York Stem Cell Foundation)

Postdoctoral Research Fellow (University of Ottawa)

Postdoctoral Positions in Epigenomics (Umeå University)

Postdoc in Human Embryonic Stem Cell Bioprocessing (School of Biotechnology at the Royal Institute of Technology)

Postdoctoral Position (Spanish National Cancer Center)

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