Volume 6.22 | Jun 8

ESC & iPSC News 6.22, June 8, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs
Scientists show that in mouse embryonic stem cells (mESCs), the genes upregulated after deletion of the H3K9 methyltransferase Setdb1 are distinct from those de-repressed in mESC deficient in the DNA methyltransferases Dnmt1, Dnmt3a, and Dnmt3b, with the exception of a small number of primarily germline-specific genes. [Cell Stem Cell]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

miR-371-3 Expression Predicts Neural Differentiation Propensity in Human Pluripotent Stem Cells
In this study, researchers characterized 13 human embryonic stem cell and 26 human induced pluripotent stem cell lines to identify markers that predict neural differentiation behavior. [Cell Stem Cell]

Co-Assembly of REST and Its Cofactors at Sites of Gene Repression in Embryonic Stem Cells
Data supports a model where productive gene repression by REST requires assembly of a multimeric “repressosome” complex, whereas weak recruitment of REST and its cofactors is insufficient to repress gene expression. [Genome Res]

Reprogramming of EBV-Immortalized B-Lymphocyte Cell Lines into Induced Pluripotent Stem Cells
Investigators reported the generation of induced pluripotent stem cell from Epstein-Barr virus (EBV) immortalized B cell lines derived from multiple inherited disease patients via a non-viral method. [Blood]

Direct Conversion of Human Fibroblasts to Dopaminergic Neurons
Recent reports demonstrate that somatic mouse cells can be directly converted to other mature cell types by using combined expression of defined factors. Scientists showed that the same strategy can be applied to human embryonic and postnatal fibroblasts. [Proc Natl Acad Sci U S A]

Generation of Induced Pluripotent Stem Cells from Urine
Researchers presented a simple, reproducible, noninvasive method for generating human induced pluripotent stem cells from renal tubular cells present in urine. [J Am Soc Nephrol]

Dissecting the Oncogenic Potential of Human Embryonic and Induced Pluripotent Stem Cell Derivatives
Investigators analyzed the gene expression patterns from three sets of human induced pluripotent stem cell- and human embryonic stem cell- derivatives and the corresponding primary cells, and compared their transcriptomes with those of five different types of cancer. [Cancer Res]

Targeted Suicide Gene Therapy for Glioma Using Human Embryonic Stem Cell-Derived Neural Stem Cells Genetically Modified by Baculoviral Vectors
Scientists reported that neural stem cells derived from HES1 human embryonic stem cell line were capable of migrating into intracranial glioma xenografts after systemic injection or after intracranial injection at a site distant from the tumor. [Gene Ther]

Derivation of High Purity Neuronal Progenitors from Human Embryonic Stem Cells
Researchers described for the first time a method for producing human neuronal progenitors in large quantity and high purity from human embryonic stem cells in feeder-free conditions, without the use of exogenous noggin, sonic hedgehog or analogs, rendering the process clinically compliant. [PLoS One]

Efficient Differentiation of Human Embryonic and Induced Pluripotent Stem Cells into Functional Astrocytes
Results demonstrated the feasibility of using induced pluripotent cell-derived astrocytes as a new potential source for therapeutic use for brain tumors and other neurological diseases. [Stem Cells Dev]

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INDUSTRY NEWS

Geron Presents Data From GRNOPC1 Trial at International Conferences on Spinal Cord Medicine and Rehabilitation
Geron Corporation announced two presentations on the company’s ongoing Phase I clinical trial of the human embryonic stem cell-based therapy, GRNOPC1, in patients with spinal cord injury. [Geron Corporation Press Release]

iPS Academia Japan, Inc. to Distribute Cellular Dynamics’ iCell® Products in Japan
Cellular Dynamics International, Inc. (CDI) announced an agreement with iPS Academia Japan, Inc., who will distribute CDI’s iCell® Cardiomyocytes, the first commercially available product based on induced pluripotent stem cells, in Japan. [Cellular Dynamics International, Inc. Press Release]

The New York Stem Cell Foundation Awards Fellowships to Seven Innovative Stem Cell Scientists
The New York Stem Cell Foundation (NYSCF) announced the appointment of seven new NYSCF-Druckenmiller Fellows, who are conducting groundbreaking research in the stem cell field. [New York Stem Cell Foundation Press Release]

POLICY NEWS

Bracing Tour of China Leaves E.U. Science Chief Impressed
Visiting China for the first time, Europe’s top research official, Máire Geoghegan-Quinn, admitted that she was bowled over by how quickly the rising power is muscling up its R&D. [European Union’s Commissioner for Research, Innovation, and Science, European Union]

Center for Scientific Review; Notice of Closed Meetings (FR Doc No: 2011-13534) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc No: 2011-13669) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meetings (FR Doc No: 2011-13794) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc No: 2011-13657) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc No: 2011-13792) [National Institutes of Health, United States]

Center for Scientific Review; Amended Notice of Meeting (FR Doc No: 2011-13793) [National Institutes of Health, United States]

Center for Scientific Review; Cancellation of Meeting (FR Doc No: 2011-13535) [National Institutes of Health, United States]

National Cancer Institute; Notice of Closed Meetings (FR Doc No: 2011-13539) [National Institutes of Health, United States]

National Cancer Institute; Amended Notice of Meeting (FR Doc No: 2011-13537) [National Institutes of Health, United States]

Roster of the Cellular, Tissue and Gene Therapies Advisory Committee [Center for Biologics Evaluation & Research, United States]

Draft Guidance for Industry and FDA Staff: Commercially Distributed In Vitro Diagnostic Products Labeled for Research Use Only or Investigational Use Only: Frequently Asked Questions; Availability [Docket No. FDA-2011-D-0305] [Food and Drug Administration, United States]

Draft Guidance for Clinical Investigators, Industry, and FDA Staff: Financial Disclosure by Clinical Investigators; Correction [Docket No. FDA-1999-D-0742 (formerly Docket No. 1999D-4396)] [Food and Drug Administration, United States]

EVENTS

NEW Wellcome Trust: Mouse Molecular Genetics
September 20-23, 2011
Hinxton, United Kingdom


NEW
 Wellcome Trust: Genetic Manipulation of ES Cells
October 31 – November 13, 2011
Hinxton, United Kingdom

Visit
our events page to see a complete list of events in the ESC & iPSC community.

JOB OPPORTUNITIES
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Senior Research Fellowship (Masaryk University)

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PhD Positions in Stem Cell Research (Masaryk University)

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Postdoc in Human Embryonic Stem Cell Bioprocessing (School of Biotechnology at the Royal Institute of Technology)

Postdoctoral Position in Stem Cells and Epigenetics (Mount Sinai School of Medicine)

Postdoctoral Fellow (Stanford University)

Postdoctoral Research Fellow (University of Ottawa)

Postdoc in Human Embryonic Stem Cell Bioprocessing (School of Biotechnology at the Royal Institute of Technology)

Postdoctoral Position (Spanish National Cancer Center)

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