Volume 6.28 | Jul 20

ESC & iPSC News 6.28, July 20, 2011
     In this issue: Science News | Current Publications | Industry News | Policy News | Events
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TOP STORY
Precision Gene Targeting in Stem Cells Corrects Disease-Causing Mutations
Using two distinct methods, researchers have successfully and consistently manipulated targeted genes in both human embryonic stem cells and induced pluripotent stem cells. [Press release from the Whitehead Institute for Biomedical Research discussing online prepublication in Cell]

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SCIENCE NEWS
Ready, Go! Researchers Pinpoint the Super Elongation Complex as a Major Regulator in the Coordinated Expression of Early Developmental Genes
An assembly of transcription elongation factors known as Super Elongation Complex helps paused RNA polymerases to come online and start transcribing the gene ahead, found researchers. [Press release from Stowers Institute for Medical Research discussing online prepublication in Genes & Development]

Stem Cell Study Reveals Complexity of Glue Molecule’s Role in Cancer
A protein molecule that ‘glues’ cells together and so has a key role in cancer is also responsible for many other important functions of cells, a new study has found. [Press release from The University of Manchester discussing online prepublication in PLoS One]

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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations
The robust capability to genetically correct disease-causing point mutations in patient-derived human induced pluripotent stem cells (hiPSCs) represents significant progress for basic biomedical research and an advance toward hiPSC-based cell replacement therapies. [Cell]

Dynamic Transcriptional Events in Embryonic Stem Cells Mediated by the Super Elongation Complex
In this study, investigators performed global genomic analyses in murine embryonic stem cells and in human cells in response to activation signals. [Genes Dev]

The Promotion of Stemness and Pluripotency Following Feeder-Free Culture of Embryonic Stem Cells on Collagen-Grafted 3-Dimensional Nanofibrous Scaffold
In this study, scientists analyzed the maintenance of stemness and pluripotency of the mouse embryonic stem cell following feeder-free culture on collagen-grafted polyethersulfone electrospun nanofibrous scaffold. [Biomaterials]

Generation of Pancreatic Insulin-Producing Cells from Rhesus Monkey Induced Pluripotent Stem Cells
Here investigators tried to generate insulin-producing cells from rhesus monkey induced pluripotent stem cells. [Diabetologia]

Depletion of Kcnq1ot1 Non-Coding RNA Does Not Affect Imprinting Maintenance in Stem Cells
Here, scientists investigated the mouse Kcnq1ot1 non-coding RNA and its role in imprinted gene regulation during preimplantation development by utilizing mouse embryonic and extra-embryonic stem cell models. [Development]

DLK1 Promotes Neurogenesis of Human and Mouse Pluripotent Stem Cell-Derived Neural Progenitors via Modulating Notch and BMP Signaling
In this study, scientists investigated the ability of Dlk1 in modulating the maintenance and differentiation of human and mouse embryonic stem cell-derived neural progenitors. [Stem Cell Rev]

Tet1 and 5-Hydroxymethylation: A Genome-Wide View in Mouse Embryonic Stem Cells
Through integrative analyses of datasets from different groups, researchers revealed the common Tet1 and 5-hydroxymethylcytosine targets in undifferentiated mouse embryonic stem cells, which suggest that Tet1 may play a key role in orchestrating the balance between pluripotent and lineage committed states. [Cell Cycle]

Stage Prediction of Embryonic Stem Cell Differentiation from Genome-Wide Expression Data
Investigators used whole-genome transcription data and several data projection methods to infer differentiation stage prediction models for embryonic cells. [Bioinformatics]

E-Cadherin Acts as a Regulator of Transcripts Associated with a Wide Range of Cellular Processes in Mouse Embryonic Stem Cells
In this study, scientists have assessed global transcript expression in E-cadherin null embryonic stem cells cultured in either the presence or absence of LIF and compared these to the parental cell line wtD3. [PLoS One]

INDUSTRY NEWS

NeoStem Signs Definitive Merger Agreement to Acquire Amorcyte in Equity Transaction
NeoStem, Inc. announced the signing of a definitive merger agreement whereby NeoStem will acquire Amorcyte, Inc. [Neostem, Inc. Press Release]

Researchers Begin First Stem Cell Trials to Treat Eye Diseases
Researchers have begun two clinical trials to determine the safety of stem cell therapy and patients’ ability to tolerate it for the treatment of two common, currently untreatable degenerative eye diseases. [University of California, Los Angeles Press Release]

POLICY NEWS

House Spending Panel Punishes OSTP Over Links to China
The Congress cuts the White House Office of Science and Technology Policy (OSTP)’s 2012 budget by 55%, from the current $6.65 million to $3 million. [White House Office of Science and Technology Policy, United States]

Embryonic Stem-Cell Approvals Rise
Research using human embryonic stem-cell lines approved under President Barack Obama is accelerating, boosting a scientific field that’s been dogged by legal and political threats. [National Institutes of Health, United States]

Will NIH Embrace Biomedical Research Prizes?
Several parts of the National Institutes of Health (NIH) held a meeting, Crowdsourcing: The Art and Science of Open Innovation, in which various government and private organizations that offer research prizes described their successes, prompting speculation over whether NIH will follow suit. [National Institutes of Health, United States]

Task Force: No Need to Pull Research Council Out of European Commission
Despite their often tumultuous relationship, there is no need to cut the European Research Council loose from the European Commission and create a new, independent organization to manage it, a task force said in a report issued. [European Research Council, European Union]

Center for Scientific Review; Notice of Closed Meeting (FR Doc No: 2011-17450) [National Institutes of Health, United States]

Center for Scientific Review; Notice of Closed Meeting (FR Doc No: 2011-17712) [National Institutes of Health, United States]

EVENTS

NEW The EMBO Meeting 2011
September 10-13, 2011
Vienna, Austria

Visit
our events page to see a complete list of events in the ESC & iPSC community.

JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Postdoctoral Position (Nanyang Technological University)

Human Embryonic Stem Cell Biologist (Matchtech)

Senior Research Fellowship (Masaryk University)

Junior Research Fellowship (Masaryk University)

PhD Positions in Stem Cell Research (Masaryk University)

PhD Positions in Medical Biology (Masaryk University)

Postdoctoral Fellow (Stanford University)

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