Volume 6.41 | Oct 19

ESC & iPSC News 6.41, October 19, 2011
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Understanding Beginnings of Embryonic Stem Cells Helps Predict Future
Scientists showed that laboratory-grown cells express a protein called Blimp1, which represses differentiation to somatic or regular tissue cells during germ cell development. [Press release from the Baylor College of Medicine discussing online prepublication in Current Biology] Press Release | Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

A Graphene-Based Platform for Induced Pluripotent Stem Cells Culture and Differentiation
Here scientists report that grapheme and graphene oxide can support mouse induced pluripotent stem cell culture and allow for spontaneous differentiation. [Biomaterials] Abstract


Fibroblast Growth Factor (FGF) Regulates Human Neuroectoderm Specification Through ERK1/2-PARP-1 Pathway
In this study researchers asked how FGF signaling leads to PAX6 transcription and neuroectoderm specification from human embryonic stem cells. [Stem Cells] Abstract


Global Phosphoproteome Profiling Reveals Unanticipated Networks Responsive to Cisplatin Treatment of Embryonic Stem Cells
Using quantitative and high-resolution tandem mass spectrometry, investigators determined global changes in protein level and phosphorylation site profiles following treatment of SILAC labeled murine embryonic stem cells with the anticancer drug cisplatin. [Mol Cell Biol] Abstract


Derivation and Characterization of Embryonic Stem Cells Lines Derived from Transgenic Fischer 344 and Dark Agouti Rats
Here, embryonic stem cell (ESC) lines were derived and characterized from Fischer 344 (F344) rats that express marker transgenes either β-galactosidase or human placental alkaline phosphatase, non-transgenic F344 rats, and from Dark Agouti rats. [Stem Cells Dev] Abstract


Production of Embryonic and Fetal-Like Red Blood Cells from Human Induced Pluripotent Stem Cells
Scientists report here that they have produced induced pluripotent stem cells from three somatic cell types: adult skin fibroblasts as well as embryonic and fetal mesenchymal stem cells. [PLoS One] Abstract

Suppression of the Imprinted Gene NNAT and X-Chromosome Gene Activation in Isogenic Human iPS Cells
Researchers have developed an isogenic system that allows direct comparison of induced pluripotent stem cells (hiPSCs) to their genetically matched human embryonic stem cells. [PLoS One] Abstract

Fiber Alignment and Coculture with Fibroblasts Improves the Differentiated Phenotype of Murine Embryonic Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Engineering
The goal of this work was to investigate how scaffold architecture and coculture with fibroblasts influences the differentiated phenotype of murine embryonic stem cell-derived cardiomyocytes. [Biotechnol Bioeng] Abstract


Derivation of Smooth Muscle Cells with Neural Crest Origin from Human Induced Pluripotent Stem Cells
In this study, scientists developed a robust protocol to derive neural crest stem cells from human embryonic stem cells and induced pluripotent stem cells. [Cells Tissues Organs] Abstract


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INDUSTRY NEWS
Cellular Dynamics International’s Human Induced Pluripotent Stem Cell Technology Named the Gold Winner in The Wall Street Journal 2011 Technology Innovation Awards
Cellular Dynamics International announced that it was named as the overall Gold winner in The Wall Street Journal Technology Innovation Awards. [Cellular Dynamics International] Press Release


Maryland Stem Cell Research Commission Issues Requests for Applications
Per the Maryland Stem Cell Commission (Commission) meeting on Sept.15, 2010, the Commission has issued three official Requests for Applications for funding through the Maryland Stem Cell Research Fund under the Maryland Stem Cell Research Act. [Maryland Stem Cell Research Fund] Press Release


New Swedish Fellowship Program Aims to Give Young Researchers a Leg Up
The Wallenberg Academy Fellows program, announced by the Knut and Alice Wallenberg Foundation in Stockholm, will give generous start-up funds and access to positions in Swedish universities to 125 grantees over the next 5 years. [ScienceInsider] Press Release
POLICY NEWS
NIH Institute Director Receives Distinguished Achievement Award
Roderic Pettigrew, Ph.D., M.D., at the National Institutes of Health (NIH) has been selected to receive the 2011 Distinguished Achievement Award from the Biomedical Engineering Society. [National Institutes of Health, United States] Press Release


NIH Grant Success Rate Likely Hit Historic Low in 2011
Grant success rates at the National Institutes of Health (NIH) appear to have plunged to an all-time low in 2011. ScienceInsider has learned that an early estimate from the NIH Office of Extramural Research puts the success rate for research grants at 17.4% for the fiscal year that ended 30 September. [National Institutes of Health, United States] Press Release


GAO Says White House Broke the Law by Holding Science Meetings with China
The Government Accountability Office (GAO) issued a report that says the White House Office of Science and Technology Policy (OSTP) has violated a provision in a 2011 spending bill that prohibits OSTP and NASA from using any money for such exchanges. [Government Accountability Office, United States] Press Release


Embryonic Stem-Cell Patents Infringe EU Law, Top Court Says
The European Union (EU)’s highest court said that stem-cell research involving human embryos can’t be patented, in a ruling that scientists called “devastating” for medical research. [European Court of Justice, European Union] Press Release


Russian Scientists Rally to Protest Funding Freeze
Several hundred researchers rallied to protest a funding freeze at Russia’s two grant organizations and on procurement regulations that they say are major obstacles for research. [Russian Academy of Science, Russia] Press Release


Brazilians Lured Back Home with Research Funding and Stability
With Brazil’s economy taking off and the country’s academic centers on the rise, more and more young scientists who went abroad for their training are toying with the idea of continuing their careers back home. [Brazilian Government, Brazil] Press Release


In Brazil, Basic Stem Cell Research Lags Behind Clinical Trials
To remedy the lag in basic stem cell science, the Brazilian government introduced several measures to give the stem cell field a boost. [Brazilian Government, Brazil] Press Release


New Framework Needed to Thwart Brazil’s Crippling Bureaucracy
To eliminate some of the red tape that has been blamed for stultifying research and innovation, an expert panel representing state funding agencies and science secretaries released a report on 26 August calling for a new code of conduct governing how scientific research is carried out in Brazil. [National council of State Research Funding Foundations, Brazil] Press Release


NIH Human Embryonic Stem Cell Registry [National Institutes of Health (NIH), United States]
EVENTS
NEW Phacilitate Cell & Gene Therapy Forum 2012
January 30-February 1, 2012
Washington, United States

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Junior/Senior Research Fellowship in Human Pluripotent Stem Cell Research (Masaryk University)

Postdoctoral Scientist (Medical Research Council)

Postdoctoral Fellow Induced Pluripotent Stem Cells in the Context of CNS Diseases (Abbott GmbH & Co. KGCo. KG)

PhD Research Position in the Department of Biological Chemistry (Weizmann Institute of Science)

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