Volume 6.42 | Oct 26

ESC & iPSC News 6.42, October 26, 2011
     In this issue: Publications | Science News | Industry News | Policy News | Events | Jobs
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TOP STORY
NKX2-5eGFP/w hESCs for Isolation of Human Cardiac Progenitors and Cardiomyocytes
Researchers targeted eGFP sequences to the NKX2-5 locus of human embryonic stem cells (hESCs); NKX2-5eGFP/w hESCs facilitate quantification of cardiac differentiation, purification of hESC-derived committed cardiac progenitor cells and cardiomyocytes and the standardization of differentiation protocols. [Nat Methods] Abstract | Press Release

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PUBLICATIONS (Ranked by Impact Factor of the Journal)
Signal-Regulatory Protein Alpha Is a Specific Cell-Surface Marker for Isolating Cardiomyocytes Derived from Human Pluripotent Stem Cells
To identify cell-surface markers specific to human cardiomyocytes, scientists screened cardiovascular cell populations derived from human embryonic stem cells against a panel of 370 known CD antibodies. [Nat Biotechnol] Abstract | Press Release

A Homozygous Mutant Embryonic Stem Cell Bank Applicable for Phenotype-Driven Genetic Screening
Here researchers developed a strategy for rapid enrichment of homozygous mutant mouse embryonic stem cells and demonstrated its feasibility for cell-based phenotypic analysis. [Nat Methods] Abstract


miR-34 miRNAs Provide a Barrier for Somatic Cell Reprogramming
Here, investigators demonstrate that miR-34 microRNAs (miRNAs), particularly miR-34a, exhibit p53-dependent induction during reprogramming. [Nat Cell Biol] Abstract | Press Release

Jarid1b Targets Genes Regulating Development and Is Involved in Neural Differentiation
Here, scientists show that the H3K4me2/3 histone demethylase Jarid1b is dispensable for embryonic stem cell (ESC) self-renewal, but essential for ESC differentiation along the neural lineage. [EMBO J] Abstract


β-Catenin/LEF1 Transactivates the MicroRNA-371-373 Cluster That Modulates the Wnt/β-Catenin-Signaling Pathway
In this study, researchers explored the relationship between the microRNA-371-373 cluster and the Wnt/β-catenin-signaling pathway, which has been shown to be involved in both stem cell maintenance and tumorigenesis. [Oncogene] Abstract


Nucleolin Maintains Embryonic Stem Cell Self-Renewal by Suppression of the p53-Dependent Pathway
Here, investigators report that nucleolin, a nucleolar protein highly expressed in undifferentiated embryonic stem cells (ESCs), plays an essential role for the maintenance of ESC self-renewal. [J Biol Chem] Abstract


Continuous Antagonism by Dkk1 Counter Activates Canonical Wnt Signaling and Promotes Cardiomyocyte Differentiation of Embryonic Stem Cells
To monitor global changes in wnt signaling during embryonic stem (ES) cell differentiation, researchers generated independent ES cell lines carrying the luciferase gene under promoters that uniquely respond to specific wnt pathway branches. [Stem Cells Dev] Abstract


Id1 Maintains Embryonic Stem Cell Self-Renewal by Up-Regulation of Nanog and Repression of Brachyury Expression
Here researchers use embryonic stem (ES) cells derived from Id deficient mice to investigate the requirement for Id proteins in maintaining ES cell self-renewal. [Stem Cells Dev] Abstract


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SCIENCE NEWS
Geron Presents Clinical Data Update from GRNOPC1 Spinal Cord Injury Trial
Geron Corporation announced two presentations on the company’s ongoing Phase I clinical trial of its human embryonic stem cell-based therapy, GRNOPC1, in patients with spinal cord injury. [Press release from Geron Corporation discussing research presented at the Pre-Conference Symposia of the Joint 2011 American Congress of Rehabilitation Medicine and American Society of Neuro-Radiology Annual Meeting, Atlanta] Press Release
INDUSTRY NEWS
Roddenberry Foundation Gives $5 Million to Gladstone for Stem Cell Research
The Gladstone Institutes and the Roddenberry Foundation inaugurated the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, a new unit founded on an unprecedented $5 million gift from the foundation that was established to honor the legacy of Star Trek creator Gene Roddenberry. [The J. David Gladstone Institute] Press Release


Rutgers Establishes Stem Cell Repository for the Study of Mental Health Disorders
Rutgers University Cell and DNA Repository has established a stem cell repository for the National Institute of Mental Health that will better enable researchers to study a variety of mental health disorders, including autism, attention deficit disorder, major depression, and schizophrenia, that affect millions of Americans. [Rutgers University] Press Release


Cellular Dynamics International’s Human Induced Pluripotent Stem Cell (iPSC) Technology Named the Gold Winner in The Wall Street Journal 2011 Technology Innovation Awards
Cellular Dynamics International announced that it was named as the overall Gold winner in The Wall Street Journal Technology Innovation Awards. [Cellular Dynamics International] Press Release

Cell Biologist Chris A. Kaiser to Lead NIH’s National Institute of General Medical Sciences
National Institutes of Health (NIH) Director Francis S. Collins, M.D., Ph.D. announced the selection of Chris A. Kaiser, Ph.D., as the new director of the National Institute of General Medical Sciences. [National Institutes of Health] Press Release
POLICY NEWS
European Research Heads Get a New Body
Fifty funding and research organizations from 23 countries joined in the founding assembly of Science Europe, an organization its members hope will give research funders a stronger voice in policy-making at the European Commission in Brussels and across the region. [Science Europe, European Union] Press Release


Vatican Bids for Italian Institute
A court will decide whether to leave the Milan-based San Raffaele Scientific Institute to its fate, or allow a consortium led by the Vatican Bank to rescue it. [San Raffaele Scientific Institute, Italy] Press Release


Super Science Suggestions: House Panel Lays Out Spending Preferences
The Republican leaders of the House of Representatives Committee on Science, Space and Technology have some suggestions on where to cut $1.5 billion from the fiscal year 2012 research budget—and they are drawing mixed reviews from science advocates. [House of Representatives Committee on Science, Space and Technology, United States] Press Release


Lobbyists Confront US Budget Crunch
On 21 September, a letter signed by more than 130 university presidents was sent to the joint select committee asking it to reach a “big agreement” so as to spare discretionary spending from drastic cuts. [Joint Select Committee on Deficit Reduction, United States] Press Release


Building a 21st Century Bioeconomy
OSTP has issued a Request for Information to solicit input from all interested parties on how best to develop the National Bioeconomy Blueprint. [Office of Science and Technology Policy (OSTP), United States] Press Release


NIH Seeks Advice on Budget Crunch
The grim outlook for biomedical research funding is causing much angst at the $30.7 billion National Institutes of Health (NIH). In an unusually candid move, NIH described some of its tough choices in detail and reached out to the scientific community for advice about how to keep afloat the labs of the investigators it funds. [National Institutes of Health, United States] Press Release
EVENTS
NEW Select Biosciences STEMCELLS 2012
February 2-3, 2012
San Diego, United States

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist (iPSC) (STEMCELL Technologies)

Contract Assay Service Technologist (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Quality Control Technologist – Cell Separation (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Junior/Senior Research Fellowship in Human Pluripotent Stem Cell Research (Masaryk University)

Postdoctoral Scientist (Medical Research Council)

Postdoctoral Fellow Induced Pluripotent Stem Cells in the Context of CNS Diseases (Abbott GmbH & Co. KGCo. KG)

PhD Research Position in the Department of Biological Chemistry (Weizmann Institute of Science)

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