Volume 6.44 | Nov 9

ESC & iPSC News 6.44, November 9, 2011
ESC & iPSC News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Erasing the Signs of Aging in Cells Is Now a Reality
Researchers have successfully rejuvenated cells from elderly donors, some over 100 years old, thus demonstrating the reversibility of the cellular aging process. To achieve this, they used an adapted strategy that consisted of reprogramming cells using a specific “cocktail” of six genetic factors, while erasing signs of aging. [Press release from the French National Institute of Health and Medical Research discussing online prepublication in Genes & Development] Press Release | Abstract


Watch the Video – Webinar: Tired of Manual Neural Rosette Isolation? Form and Isolate More Efficiently.
PUBLICATIONS (Ranked by Impact Factor of the Journal)
Dopamine Neurons Derived from Human Embryonic Stem Cells Efficiently Engraft in Animal Models of Parkinson’s Disease
Here scientists present a novel floor-plate-based strategy for the derivation of human dopamine neurons that efficiently engraft in vivo, suggesting that past failures were due to incomplete specification rather than a specific vulnerability of the cells. [Nature] Abstract | Press Release

Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
Here researchers present a suite of techniques, based on ribosome profiling, to provide genome-wide maps of protein synthesis as well as a pulse-chase strategy for determining rates of translation elongation. [Cell] Abstract


In Embryonic Stem Cells, ZFP57/KAP1 Recognize a Methylated Hexanucleotide to Affect Chromatin and DNA Methylation of Imprinting Control Regions
Here, investigators reveal that ZFP57, its cofactor KAP1, and associated effectors bind selectively to the H3K9me3-bearing, DNA-methylated allele of imprinting control regions in embryonic stem cells. [Mol Cell] Abstract


Surface-Engineered Substrates for Improved Human Pluripotent Stem Cell Culture Under Fully Defined Conditions
Here, researchers develop a spatially defined culture system based on UV/ozone radiation modification of typical cell culture plastics to define a favorable surface environment for human pluripotent stem cell culture. [Proc Natl Acad Sci USA] Abstract | Press Release

Highly Efficient Derivation of Ventricular Cardiomyocytes from Induced Pluripotent Stem Cells with a Distinct Epigenetic Signature
Here, scientists demonstrate that induced pluripotent stem cells (iPSCs) can be derived from murine ventricular myocytes (VMs), and consistent with other reports of iPSCs derived from various somatic cell types, VM-derived iPSCs exhibit a markedly higher propensity to spontaneously differentiate into beating cardiomyocytes as compared to genetically matched embryonic stem cells or iPSCs derived from tail-tip fibroblasts. [Cell Res] Abstract


The Metabolome of Induced Pluripotent Stem Cells Reveals Metabolic Changes Occurring in Somatic Cell Reprogramming
Researchers report, using an untargeted metabolomics approach, that human induced pluripotent stem cells (iPSCs) share a pluripotent metabolomic signature with embryonic stem cells that is distinct from their parental cells, and that is characterized by changes in metabolites involved in cellular respiration. [Cell Res] Abstract


Derivation of New Human Embryonic Stem Cell Lines Reveals Rapid Epigenetic Progression In Vitro That Can Be Prevented by Chemical Modification of Chromatin
Data demonstrate that self-renewal and survival of class I nuclei are compatible with normoxic human embryonic stem cell (hESC) derivation, and that chemical supplementation after derivation provides a strategy to prevent epigenetic progression and retain nuclei with two active X chromosomes in the self renewing state. [Hum Mol Genet] Abstract


Efficient Generation of Functional Hepatocytes from Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4α Transduction
Although investigators recently reported that hepatic commitment is promoted by transduction of SOX17 and HEX into human embryonic stem cell- and induced pluripotent stem cell-derived cells, these hepatocyte-like cells were not sufficiently mature for drug screening. To promote hepatic maturation, they utilized transduction of the hepatocyte nuclear factor 4α (HNF4α) gene, which is known as a master regulator of liver-specific gene expression. [Mol Ther] Abstract


Resveratrol Protects Mouse Embryonic Stem Cells from Ionizing Radiation by Accelerating Recovery from DNA Strand Breakage
To learn whether resveratrol can protect stem cells from DNA damage and to study its effects on genomic integrity, scientists exposed mouse embryonic stem cells pre-treated with resveratrol to ionizing radiation. [Carcinogenesis] Abstract


Watch the Video – Webinar: Affordable, Defined hPSC Culture? StemAdhere™ “Sticks It” to Other Matrices.
INDUSTRY NEWS
Advanced Cell Technology Announces 2011 Third Quarter Results
Advanced Cell Technology, Inc. announced third quarter financial results for the period ended September 30, 2011. [Advanced Cell Technology, Inc.] Press Release

Patent Issued for OHSU Stem Cell Cloning
Oregon Health & Science University (OHSU)’s unique method of transforming a person’s own skin cells into stem cells has officially been patented. [Oregon Health & Science University] Press Release


UCSF Training Program Attracts Best Minds in Developmental, Stem Cell Biology
Fittingly enough for a University where embryonic stem cells were first discovered in mice and named, the University of California, San Francisco (UCSF) has launched a pioneering program in Developmental and Stem Cell Biology. [University of California, San Francisco] Press Release
POLICY NEWS
Court Endorses Vatican Bank’s Rescue of Italian Research Center
On Friday, 28 October, an Italian bankruptcy court gave the green light to an offer made by the Institute for Works of Religion, more commonly known as the Vatican Bank, and Italian entrepreneur Victor Malacalza to rescue the deeply in debt San Raffaele del Monte Tabor Foundation, which runs a clinical research hospital, an internationally respected basic science institute, and more at a research park in Milan. [Italian Bankruptcy Court, Italy] Press Release


Spanish Institute Faces Cash Crisis
The Prince Felipe Research Centre announced an emergency financial plan on 19 October that would see about 100 research staff lose their jobs, and roughly halve salaries for those who remain. [Prince Felipe Research Centre, Spain] Press Release


U.S. Official Defends Science-Technology Exchanges with China
President Barack Obama’s top science official said U.S.-China science cooperation benefits the United States, rejecting moves to curb the exchanges by lawmakers who say it strengthens China’s military. [Office of Science and Technology, United States] Press Release


Texas Delays Action on Stem Cell Therapy Rules
The Texas State Medical Board voted to delay until next year final approval of new stem cell therapy rules that could restrict – or even block – procedures such as the one Gov. Rick Perry recently underwent on his aching back. [Texas State Medical Board, United States] Press Release


Good Clinical Practice (GCP) Forum Launched
The Medicines and Healthcare Regulatory Agency announced that a new Agency discussion forum for Good Clinical Practice has been launched. [Medicines and Healthcare Regulatory Agency, United Kingdom] Press Release
EVENTS
NEW International Society for Cellular Therapy
June 5-8, 2012
Seattle, United States

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Lab Technologist – Tissue Culture (STEMCELL Technologies)

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Lab Technologist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Scientist – Differentiation Segment (Stemgent, Inc.)

Junior/Senior Research Fellowship in Human Pluripotent Stem Cell Research (Masaryk University)

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