Volume 7.01 | Jan 11

ESC & iPSC News 7.01 January 11, 2012
ESC & iPSC News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells
Here scientists show that pluripotency and differentiation of mouse embryonic stem cells is regulated by different Cbx-associated Polycomb repressive complex 1 complexes with unique functions. [Cell Stem Cell] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Generation of Chimeric Rhesus Monkeys
Here, researchers demonstrate that rhesus monkey embryonic stem cells and isolated inner cell masses fail to incorporate into host embryos and develop into chimeras. However, chimeric offspring were produced following aggregation of totipotent cells of the four-cell embryos. [Cell] Abstract | Press Release

MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs during ESC Differentiation
Researchers have identified Cbx7 as the primary Polycomb ortholog of Polycomb repressive complex 1 complexes in embryonic stem cells (ESCs). [Cell Stem Cell] Abstract

Rett Syndrome Induced Pluripotent Stem Cell-Derived Neurons Reveal Novel Neurophysiological Alterations
Here, researchers describe the first characterization and neuronal differentiation of induced pluripotent stem cells derived from methyl-CpG-binding protein 2 (Mecp2)-deficient mice. [Mol Psychiatry] Abstract

Attenuation of Extrinsic Signaling Reveals the Importance of Matrix Remodeling on Maintenance of Embryonic Stem Cell Self-Renewal
Researchers found that perturbing cell-secreted signaling causes mouse embryonic stem cells to exit their stable self-renewing state in defined conditions that normally support self-renewal and to exhibit properties characteristic of epiblast cells. [Proc Natl Acad Sci USA] Abstract

miR-290 Cluster Modulates Pluripotency by Repressing Canonical NF-κB Signaling
Here researchers demonstrate that miR-290 cluster, the most abundant microRNA family in embryonic stem cells, targets the NF-κB subunit p65 (also known as RelA) by repressing its translation. [Stem Cells] Abstract

A Role for MicroRNAs 99b, 181a and 181b in the Differentiation to Vascular Endothelial Cells from Human Embryonic Stem Cells
Here, researchers show that the reduction of microRNA maturation induced by Dicer knockdown suppressed human embryonic stem-endothelial cell differentiation. [Stem Cells] Abstract

Differentiation and Functional Incorporation of Embryonic Stem Cell-Derived GABAergic Interneurons in the Dentate Gyrus of Mice with Temporal Lobe Epilepsy
Investigators transplanted mouse embryonic stem cell-derived neural progenitors with ventral forebrain identities into the hilus of the dentate gyrus of mice with temporal lobe epilepsy and evaluated graft differentiation, mossy fiber sprouting, cellular morphology, and electrophysiological properties of the transplanted neurons. [J Neurosci] Abstract

The Endothelial Cell Line bEnd.3 Maintains Human Pluripotent Stem Cells
Here, researchers show that a transformed mouse endothelial cell line (bEnd.3) maintains human pluripotent stem cells in an undifferentiated state. [Stem Cells Dev] Abstract

The Expression of the Class I Glucose Transporter Isoforms in Human Embryonic Stem Cells, and the Potential Use of GLUT2 as a Marker for Pancreatic Progenitor Enrichment
Researchers analyzed changes in expression of class I glucose transporters (GLUT1-4) during human embryonic stem cell and human induced pluripotent stem cell differentiation, from undifferentiated cells to 28 day old embryoid bodies. [Stem Cells Dev] Abstract

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INDUSTRY NEWS

New Source of Stem Cell Generation Pioneered
A process that prompts a single gene to generate millions of supercharged stem cells, which can then turn into any kind of cell a body needs to repair itself, has been patented. [University of Central Florida College of Medicine] Press Release

Amorcyte, a NeoStem Company, Announces Expansion of Intellectual Property Coverage
Amorcyte, Inc. announced the expansion of  intellectual property protection around its lead product candidate, AMR-001, with the grant of U.S. patent number 8,088,370 by the United States Patent and Trademark Office. [NeoStem, Inc.] Press Release

Michael A. Marletta Takes Office as New President of Scripps Research Institute
Renowned biochemist Michael A. Marletta, PhD, assumed the post of president and CEO of The Scripps Research Institute, succeeding Richard A. Lerner, MD, who led the institution for more than two decades. [The Scripps Research Institute] Press Release

POLICY NEWS

China Stops Unapproved Stem Cell Treatments
China has ordered a halt to all unapproved stem cell treatments and clinical trials as Beijing seeks to rein in the largely untested stem cell therapies now on offer across the country. [The Ministry of Health, China] Press Release

FDA Warns About Stem Cell Claims
FDA cautions consumers to make sure that any stem cell treatment they are considering has been approved by FDA or is being studied under a clinical investigation that has been submitted to and allowed to proceed by FDA. [U.S. Food and Drug Administration, United States] Press Release

National Institute of General Medical Sciences Reorganizes
The National Institute of General Medical Sciences (NIGMS) has established two new divisions. Each will administer existing NIGMS programs along with programs transferred to NIGMS from the former National Institutes of Health National Center for Research Resources. [National Institutes of Health, United States] Press Release

Privately-Funded Science University Plan
A new type of privately-funded science and technology university has been announced by the universities minister. [Universities Minister, United Kingdom] Press Release

EVENTS
NEW Cell Culture World Congress
February 28-March 1, 2012
Munich, Germany

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

Postdoctoral Position (University of California, Davis)

PhD Research Fellowship, Centre for Molecular Medicine (University of Oslo)

Junior Research Fellow (Christian Medical College)

Postdoctoral Positions (National Centre for Biological Sciences)

Scientist – Differentiation Segment (Stemgent, Inc.)


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