Volume 7.02 | Jan 18

ESC & iPSC News 7.02, January 18, 2012
ESC & iPSC News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Smooth Muscle Cells Created from Patients’ Skin Cells
Scientists have for the first time created different types of vascular smooth muscle cells using cells from patients’ skin. [Press release from the University of Cambridge discussing online prepublication in Nature Biotechnology] Press Release | Abstract

Webinar: Groundbreaking Applications for Feeder-Free hESC & hiPSC Culture. Watch Now.
PUBLICATIONS (Ranked by Impact Factor of the Journal)

Programming Human Pluripotent Stem Cells into White and Brown Adipocytes
Here researchers report the robust and efficient differentiation of human pluripotent stem cells into white or brown adipocytes. [Nat Cell Biol] Abstract

Chondrogenic Differentiation of Induced Pluripotent Stem Cells from Osteoarthritic Chondrocytes in Alginate Matrix
In the present study, researchers investigated the differentiation potential of osteoarthritic chondrocytes (OCs) into induced pluripotent stem cells (iPSCs) using defined transcription factors and explored the possibility of using these OC-derived iPSCs for chondrogenesis. [Eur Cell Mater] Abstract

Nrf3-Pla2g7 Interaction Plays an Essential Role in Smooth Muscle Cell Differentiation from Stem Cells
In this study, embryonic stem cells were cultivated on collagen IV-coated plates to allow smooth muscle cell differentiation. [Arterioscler Thromb Vasc Biol] Abstract

VZV Infects Human Embryonic Stem Cell-Derived Neurons and Neurospheres, but Not Pluripotent Embryonic Stem Cells or Early Progenitors
In the present study researchers examine whether pluripotent human embryonic stem cells and neural progenitors at intermediate stages of differentiation are permissive for varicella zoster virus infection. [J Virol] Abstract

A Molecular Signature for Purified Definitive Endoderm Guides Differentiation and Isolation of Endoderm from Mouse and Human Embryonic Stem Cells
Here, investigators describe purification of mouse definitive endoderm using fluorescence-activated cell sorting and mice harboring a transgene encoding enhanced green fluorescent protein inserted into the Sox17 locus, which is expressed in embryonic endoderm. [Stem Cells Dev] Abstract

Generation and Characterization of Leukemia Inhibitory Factor-Dependent Canine Induced Pluripotent Stem Cells from Adult Dermal Fibroblasts
In this study scientists describe the production of canine induced pluripotent stem cells from adult dermal fibroblasts. [Stem Cells Dev] Abstract

Cycle Arrest and Aneuploidy Induced by Zidovudine in Murine Embryonic Stem Cells
Researchers used murine embryonic stem cells as a model to investigate the consequences of zidovudine exposure for embryogenesis. [Mutagenesis] Abstract

Evaluation of the Use of an Induced Pluripotent Stem Cell Sheet for the Construction of Tissue-Engineered Vascular Grafts
In this study, investigators evaluated the use of a sheet created from induced puripotent stem cell-derived vascular cells as a potential source for the construction of a tissue-engineered vascular graft. [J Thorac Cardiovasc Surg] Abstract

Mineralocorticoid Receptor Overexpression Facilitates Differentiation and Promotes Survival of Embryonic Stem Cell-Derived Neurons
To investigate the impact of mineralocorticoid receptor (MR) in neuronal survival, investigators generated murine embryonic stem cells that overexpress human MR and are induced to differentiate into mature neurons. [Neuroendocrinology] Abstract

A Method for Deriving Homogenous Population of Oligodendrocytes from Mouse Embryonic Stem Cells
Researchers describe clear methodology for differentiation of mouse embryonic stem cells to oligodendrocyte to a high degree of homogenity and reproducibility in vitro. [Dev Neurobiol] Abstract

Use AggreWell™ for Reproducible, Uniform Embryoid Bodies

INDUSTRY NEWS

California State University, Long Beach (CSULB) Receives 3-Year, Nearly $1.7 Million Renewal Grant to Fund Stem Cell Research Internships
The caliber of the interns, selected from students in the stem cell option of CSULB’s Biotechnology Certificate program, pleased the California Institute for Regenerative Medicine officials enough to result in a three-year, $1,686,998 grant renewal for the university. [California State University, Long Beach]
Press Release

Vectalys Has Signed a Licensing Agreement with Kyoto University
Kyoto University, iPS Academia Japan Inc., and Vectalys, announced they have entered into a series of intellectual property agreements covering induced pluripotent stem cell technology. [Vectalys] Press Release

Plasticell to Collaborate with Pfizer, Cellzome and University of Sheffield in a £1.4 Million Technology Strategy Board-Funded Stem Cell Project
The project will develop methods of characterizing stem cells through protein fingerprints predictive of changes in stem cell behavior. [Plasticell] Press Release

POLICY NEWS

NSF Tweaks Its Merit Review Rules
The National Science Board has made two subtle but potentially important changes in how grant applications are reviewed at the National Science Foundation (NSF). [National Science Board, United States]
Press Release

Peru to Boost Science-Industry Links
The Peruvian government will provide US $100 million for a new project aiming to finance and promote the development of science and technology links between the private sector, universities, and public and private research centers. [The Peruvian Government, Peru] Press Release

US Translational-Science Center Gets Under Way
Scarcely a year after plans to establish it were made public, the National Center for Advancing Translational Sciences, the newest branch of the US National Institutes of Health in Bethesda, Maryland, is up and running. [National Institutes of Health, United States] Press Release

Bill Blocking National Institutes of Health Public Access Policy Draws Fire
A little-noticed proposal in Congress to block a federal policy requiring free access to biomedical research papers went big time, adding fuel to a long-running debate in the blogosphere. [The United States Congress, United States] Press Release

EVENTS

NEW Molecular Medicine Tri-Conference
February 19-23, 2012
San Francisco, United States

NEW Drug Discovery World Asia
March 19-22, 2012
Singapore, Singapore

Visit
our events page to see a complete list of events in the ESC & iPSC community.

JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

Postdoctoral Position (University of California, Davis)

PhD Research Fellowship, Centre for Molecular Medicine (University of Oslo)

Scientist – Differentiation Segment (Stemgent, Inc.)


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