Volume 7.04 | Feb 1

ESC & iPSC News 7.04, February 1, 2012
ESC & iPSC News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Probing Sporadic and Familial Alzheimer’s Disease Using Induced Pluripotent Stem Cells
Here investigators reprogrammed primary fibroblasts from two patients with familial Alzheimer’s disease, both caused by a duplication of the amyloid-ß precursor protein gene, two with sporadic Alzheimer’s disease and two non-demented control individuals into induced pluripotent stem cell lines. [Nature] Abstract | Press Release

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Modeling Hepatitis C Virus Infection Using Human Induced Pluripotent Stem Cells
Here researchers report that hepatocyte-like cells derived from induced pluripotent stem cells support the entire life cycle of hepatitis C virus, including inflammatory responses to infection, enabling studies of how host genetics impact viral pathogenesis. [Proc Natl Acad Sci USA] Abstract | Press Release

Direct Conversion of Mouse Fibroblasts to Self-Renewing, Tripotent Neural Precursor Cells
Researchers hypothesized that neural precursor cell (NPC)-like cells may be induced using the same principal approach used for generating “induced neuronal” cells. Toward this goal, the researchers infected mouse embryonic fibroblasts derived from Sox2-EGFP mice with a set of 11 transcription factors highly expressed in NPCs. [Proc Natl Acad Sci USA] Abstract | Press Release

SFRP1 and 2 Dose-Dependently Regulate Midbrain Dopamine Neuron Development In Vivo and in Embryonic Stem Cells
Secreted Frizzled related proteins (sFRPs) are a family of proteins that modulate Wnt signaling, which in its turn regulates multiple aspects of ventral midbrain and dopaminergic (DA) neuron development. Here, researchers show that sFRP1 and sFRP2 activate the Wnt/PCP/Rac1 pathway in DA cells. [Stem Cells] Abstract

Concentration-Dependent Requirement for Local Protein Synthesis in Motor Neuron Subtype-Specific Response to Axon Guidance Cues
Using a growth cone collapse assay, researchers demonstrate that mouse embryonic stem cell-derived spinal motor neurons respond to ephrin-A5, Sema3f, and Sema3a in a concentration-dependent manner. [J Neurosci] Abstract

The Roles of FGF and MAP Kinase Signaling in the Segregation of the Epiblast and Hypoblast Cell Lineages in Bovine and Human Embryos
The inability to derive embryonic stem cell lines in a variety of species suggests divergence between species in the cell signaling pathways involved in early lineage specification. Here researchers examined segregation of the hypoblast and epiblast lineages in bovine and human embryos through modulation of FGF/MAP kinase signaling pathways in cultured embryos. [Development] Abstract

Ribosomal Stress Induces L11- and p53-Dependent Apoptosis in Mouse Pluripotent Stem Cells
Here, researchers show that treatment with low doses of Actinomycin D or depletion of ribosomal protein L37, two well-established inducers of ribosomal stress, activate p53 in an L11-dependent manner in mouse embryonic stem cells and in induced pluripotent stem cells. [Cell Cycle] Abstract

MicroRNA-125b/Lin28 Pathway Contributes to the Mesendodermal Fate Decision of Embryonic Stem Cells
Here researchers report novel functions of microRNA-125b/Lin28 axis in the regulation of mouse embryonic stem cell lineage specification and cardiomyocyte differentiation. [Stem Cells Dev] Abstract

TGFß1 Inhibits Lymphatic Endothelial Cell Differentiation from Mouse Embryonic Stem Cells
In this work, researchers identified Transforming Growth Factor-ß1 (TGFß1) as a negative regulator of lymphvasculogenesis from embryonic stem cell-derived vascular progenitors. [J Cell Physiol] Abstract

Directed Differentiation of Embryonic Stem Cells Allows Exploration of Novel Transcription Factor Genes for Pancreas Development
Researchers hypothesize that, if directed differentiation in vitro recapitulates the developmental process in vivo, embryonic stem cells provide a powerful model to discover novel pancreatic transcription factor genes. [Stem Cell Rev Rep] Abstract

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INDUSTRY NEWS

Maryland Stem Cell Research Commission Announces New Program for Pre-Clinical and Clinical Research Grants
The Maryland Stem Cell Research Commission has announced a new program for pre-clinical and clinical research grants. This program will support for-profit companies in advancing medical therapies using human stem cells. [Maryland Stem Cell Research Fund] Press Release

World-Class Scientists Chosen for HHMI’s First International Early Career Award
Top biomedical scientists from 12 countries will receive an important boost at a critical time in their careers from the Howard Hughes Medical Institute’s (HHMI’s) inaugural International Early Career Scientist awards. [Howard Hughes Medical Institute] Press Release

POLICY NEWS

United Kingdom Sets Sights on Gene Therapy in Eggs
Public consultation and safety assessment would pave the way for embryo manipulation to treat genetic diseases. [Human Fertilisation and Embryology Authority, United Kingdom] Press Release

National Academy Picks UC Administrator for Top Staff Job
Bruce Darling, now vice president for laboratory management at the University of California (UC), was named to the job of overseeing day-to-day operations at U.S. National Academy of Sciences and its operating arm, the National Research Council. [U.S. National Academy of Sciences, United States] Press Release

Research in Asia Heats Up
US indicators reveal challenges and opportunities as science momentum shifts to China. [US National Science Board, United States] Press Release

EVENTS

NEW Experimental Biology (EB) 2012
April 21-25, 2012
San Diego, United States

NEW Engineering Conferences International (ECI) – Cell Culture Engineering XIII
April 22-27, 2012
Scottsdale, United States

Visit
our events page to see a complete list of events in the ESC & iPSC community.

JOB OPPORTUNITIES

Research and Development Technologist, hPSC Media (STEMCELL Technologies)

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Research Technologist, Manufacturing Sciences (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

Scientist – Differentiation Segment (Stemgent, Inc.)

PhD Student Position: Stem Cells, Neurogenesis, Human IPS Cells, Cell Biology (Institute for Anatomy & Cell Biology, Ulm University)

Postdoctoral Fellow Position: Stem Cells (University of California, Davis)


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