Volume 7.06 | Feb 15

ESC & iPSC News 7.06, February 15, 2012
ESC & iPSC News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Purinergic Signaling in Human Pluripotent Stem Cells Is Regulated by the Housekeeping Gene Encoding Hypoxanthine Guanine Phosphoribosyltransferase
In these studies aimed at characterizing purinergic signaling in hypoxanthine guanine phosphoribosyltransferase (HPRT) deficiency, investigators used a lentivirus vector stably expressing an shRNA targeted to the HPRT gene to produce HPRT-deficient human CVB induced pluripotent stem cells and human HUES11 embryonic stem cells. [Proc Natl Acad Sci USA] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Control of Ground-State Pluripotency by Allelic Regulation of Nanog
Researchers suggest that the tight regulation of Nanog dose at the chromosome level is necessary for the acquisition of ground-state pluripotency during development. [Nature] Abstract

Predictive Microfluidic Control of Regulatory Ligand Trajectories in Individual Pluripotent Cells
Experimental validation using functional activation of signal transducer and activator of transcription3 (STAT3) by secreted factors under microfluidic perfusion culture demonstrated that STAT3 activation and consequently mouse embryonic stem cell fate were manipulable by flow rate, position in the flow field, and local cell organization. [Proc Natl Acad Sci USA] Abstract

Tumor Tropism of Intravenously Injected Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells and Their Gene Therapy Application in a Metastatic Breast Cancer Model
Using a dual-color whole body imaging technology, researchers demonstrated that after tail vein injection human neural stem cells displayed a robust migratory capacity outside the central nervous system in both immunodeficient and immunocompetent mice and homed in on established orthotopic 4T1 mouse mammary tumors. [Stem Cells] Abstract

High Prevalence of Evolutionarily-Conserved and Species-Specific Genomic Aberrations in Mouse Pluripotent Stem Cells
The genomic stability of pluripotent stem cells (PSCs) is a matter of profound significance, as it affects their pluripotency, differentiation and tumorigenicity. Researchers found that genomic aberrations occur frequently in mouse embryonic stem cells of various mouse strains, and in mouse induced PSCs of various cell origins and derivation techniques. [Stem Cells] Abstract

Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC-Derived Neural Cells in a Primate Model of Parkinson’s Disease
Investigators have herein compared the growth and function of human embryonic stem cell (ESC)-derived cells with different stages of neural differentiation implanted in the brains of primate models of Parkinson’s disease. [Stem Cells] Abstract

Dystrophin-Compromised Sarcoglycan-δ Knockout Diaphragm Requires Full Wild Type Embryonic Stem Cell Reconstitution for Correction
Researchers produced mosaic mice through the injection of wild type embryonic stem cells into sarcoglycan-δ knockout blastocysts. [J Cell Sci] Abstract

MacroH2A1 Regulates the Balance between Self-Renewal and Differentiation Commitment in Embryonic and Adult Stem Cells
Here, researchers provide insight in the poorly recognized function of macroH2A in transcriptional activation and demonstrate its relevance in embryonic and adult stem cells. [Mol Cell Biol] Abstract

Transplantation of Telencephalic Neural Progenitors Induced from Embryonic Stem Cells into Subacute Phase of Focal Cerebral Ischemia
Researchers’ aim was to establish cell therapy for cerebral ischemia using embryonic stem cells. [Lab Invest] Abstract

Derivation of Male Germ Cells from Induced Pluripotent Stem Cells In Vitro and in Reconstituted Seminiferous Tubules
The aim of this study was to explore differentiation potential of induced pluripotent stem cells to male germ cells in vitro and in vivo. [Cell Prolif] Abstract

Small Molecule Mesengenic Induction of Human Induced Pluripotent Stem Cells to Generate Mesenchymal Stem/Stromal Cells
Researchers devised a single-step method to direct mesengenic differentiation of human embryonic stem cells and induced pluripotent stem cells using a small molecule inhibitor. [Stem Cells Transl Med]
Abstract | Press Release

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INDUSTRY NEWS

U-M Human Embryonic Stem Cell Line Placed on National Registry
The University of Michigan’s (U-M’s) first human embryonic stem cell line will be placed on the U.S. National Institutes of Health’s registry, making the cells available for federally-funded research. [University of Michigan Health System] Press Release

ACT Announces Third Patient with Stargardt’s Disease Treated in U.S. Clinical Trial with RPE Cells Derived from Embryonic Stem Cells
Advanced Cell Technology, Inc. (ACT) announced the dosing of third patient in its Phase I/II trial for Stargardt’s macular dystrophy using retinal pigment epithelial (RPE) cells derived from human embryonic stem cells. [Advanced Cell Technology, Inc.] Press Release

ACT Announces Approval of Wills Eye Institute as Additional Site for Stem Cell Clinical Trial for Stargardt’s Disease
Advanced Cell Technology, Inc. (ACT) announced that the Wills Eye Institute in Philadelphia has received institutional review board approval as a site for the company’s Phase I/II clinical trial for Stargardt’s Macular Dystrophy using human embryonic stem cell-derived retinal pigment epithelial cells. [Advanced Cell Technology, Inc.] Press Release

Cytomedix Expands Commitment to Regenerative Medicine with Acquisition of Aldagen
Cytomedix, Inc. announces the completion of the acquisition of Aldagen, Inc., a privately held biopharmaceutical company developing regenerative cell therapies based on its proprietary ALDH bright cell technology. [Cytomedix, Inc.] Press Release

POLICY NEWS

A Flat Budget for NIH in 2013
There’s little to cheer biomedical researchers in the president’s budget proposal released today: the proposal would hold the National Institutes of Health’s (NIH’s) budget at the current level of $30.86 billion. [National Institutes of Health, United States] Press Release

NSF Tops Research Agencies with a $340-Million Boost
President Barack Obama proposed a 4.8% increase in funding for the National Science Foundation (NSF) as part of his $3.8-trillion budget request for 2013. The $340-million boost is the largest absolute increase in spending for any federal research agency. [National Science Foundation, United States] Press Release

FDA Stays the Course, But Asks Firms to Kick In More Fees
In the 2013 budget proposal, user fees would increase to $1.97 billion, from $1.33 billion in 2012, while the amount provided by the Administration would hold steady at $2.5 billion. [Food and Drug Administration (FDA), United States] Press Release

New Governance Structure Approved by AMP Membership
The members of the Association for Molecular Pathology (AMP) voted in favor of adopting significant changes to the structure of its governing body. [Association for Molecular Pathology, United States]
Press Release

Lawmakers Reintroduce Public Access Bill
Lawmakers introduced a proposal to make scientific papers funded with taxpayer money available for free on the Internet. [The Federal Research Public Access Act, United States] Press Release

Duplicate-Grant Case Puts Funders Under Pressure
Critics call for tighter checks to stop researchers being funded twice for the same work. [National Science Foundation, United States] Press Release

Europe Experiments with Joined-Up Research
In an unprecedented effort to break through the geopolitical barriers to collaboration, European researchers launched a joint strategy to prioritize and coordinate research on neurodegenerative diseases such as Alzheimer’s and Parkinson’s. [Joint Programme in Neurodegenerative Disease Research, European Union] Press Release

EVENTS

NEW 2012 Till & McCulloch Meetings
April 30-May 2, 2012
Montreal, Canada

NEW Genetic Manipulation of ES Cells
November 5-18, 2012
Hinxton, United Kingdom

Visit
our events page to see a complete list of events in the ESC & iPSC community.

JOB OPPORTUNITIES

Scientist – Pluripotent Stem Cells (STEMCELL Technologies)

Business Analyst – Product Management (STEMSOFT Software)

Research Technologist (STEMCELL Technologies)

Scientist – hPSC (STEMCELL Technologies)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies)

Postdoctoral/Research Associate (Children’s Memorial Research Center)

Scientist – Differentiation Segment (Stemgent, Inc.)

Postdoctoral Fellow Position: Stem Cells (University of California, Davis)

Postdoctoral Scientist – Stem Cell Research (Paterson Institute)


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