Volume 7.12 | Mar 28

ESC & iPSC News 7.12, March 28, 2012
ESC & iPSC News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Derivation, Expansion and Differentiation of Induced Pluripotent Stem Cells in Continuous Suspension Cultures
Researchers describe derivation of induced pluripotent stem cells from terminally differentiated mouse cells in serum- and feeder-free stirred suspension cultures. [Nat Methods] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)

Embryonic Stem Cells Induce Pluripotency in Somatic Cell Fusion through Biphasic Reprogramming
Investigators examine how trans– versus cis-silenced genes in a somatic cell type behave in fusions to another somatic cell type or to embryonic stem cells. [Mol Cell] Abstract

Dynamic HoxB4 Regulatory Network during Embryonic Stem Cell Differentiation to Hematopoietic Cells
Researchers performed global gene expression profiling and chromatin immunoprecipitation coupled with deep sequencing at four stages of the HoxB4-mediated embryonic stem cell differentiation towards hematopoietic cells. [Blood] Abstract

HIF1α Induced Switch from Bivalent to Exclusively Glycolytic Metabolism during ESC-to-EpiSC/Human ESC Transition
Researchers show that hypoxia-inducible factor 1α (HIF1α) is sufficient to drive embryonic stem cells (ESC) to a glycolytic Activin/Nodal-dependent epiblast stem cell (EpiSC)-like stage. [EMBO J]
Abstract | Press Release

Mutant Induced Pluripotent Stem Cell Lines Recapitulate Aspects of TDP-43 Proteinopathies and Reveal Cell-Specific Vulnerability
Researchers report the generation of induced pluripotent stem cells that carry the transactive response DNA-binding (TDP-43) M337V mutation and their differentiation into neurons and functional motor neurons. [Proc Natl Acad Sci USA] Abstract | Press Release

Combining Competition Assays with Genetic Complementation Strategies to Dissect Mouse Embryonic Stem Cell Self-Renewal and Pluripotency
To gain a comprehensive understanding of the molecular mechanisms regulating mouse embryonic stem cell self-renewal and lineage differentiation, researchers have developed a robust method for studying the role of a particular gene in these processes. [Nat Protoc] Abstract

The Promotion of Hepatic Maturation of Human Pluripotent Stem Cells in 3D Co-Culture Using Type I Collagen and Swiss 3T3 Cell Sheets
Hepatic maturation of human embryonic stem cell- or human induced pluripotent stem cell-derived hepatocyte-like cells by three-dimensional (3D) co-culture systems has not been examined. Researchers utilized a cell sheet engineering technology to promote hepatic maturation. [Biomaterials] Abstract

Pluripotent Stem Cell-Engineered Cell Sheets Re-Assembled with Defined Cardiovascular Populations Ameliorate Reduction in Infarct Heart Function through Cardiomyocyte-Mediated Neovascularization
Investigators show the potentials and mechanisms of cardiac tissue sheet transplantation in cardiac function after myocardial infarction. [Stem Cells] Abstract

Hybridization of Testis-Derived Stem Cells with Somatic Cells and Embryonic Stem Cells in Mice
Hybrids were successfully obtained between germline stem (GS) cells and embryonic stem cells, between GS cells and multipotent GS (mGS) cells, and between mGS cells and thymocytes. [Biol Reprod] Abstract

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INDUSTRY NEWS

CSIR Makes a Breakthrough in Biomedical Stem Cell Technology
The Council for Scientific and Industrial Research (CSIR)’s Gene Expression and Biophysics Group has generated the first induced pluripotent stem cells in Africa. [Council for Scientific and Industrial Research] Press Release

UC San Diego, Taiwan’s Academia Sinica to Collaborate on Research
University of California (UC) San Diego and Taiwan’s Academia Sinica have agreed to collaborate across a broad range of research areas. [University of California, San Diego] Press Release

POLICY NEWS

BIO Praises Senate Passage of the Jumpstart Our Business Startups (JOBS) Act
The Biotechnology Industry Organization (BIO) applauds the Senate on the passage of H.R. 3606, the JOBS Act. The JOBS Act contains several provisions which would make the pathway to capital formation more attainable for small biotechnology companies. [Biotechnology Industry Organization, United States]
Press Release

Activists Ground Primate Flights
In a campaign that could affect scientists across the West, the few major air carriers that still transport non-human primates are coming under unprecedented pressure to halt the practice. [People for the Ethical Treatment of Animals, United States] Press Release

Indian Budget Disappoints
The Indian government’s budget for 2012-13 promised increases of between 2% and 18% for most of its scientific departments, disappointing researchers who note that the country’s 7% inflation rate will consume most of the extra cash. [Indian Science Congress, India] Press Release

Numbers of Young Scientists Declining in Japan
Junior researchers are being squeezed out of Japanese universities by government policies aimed at cutting costs. [Council for Science and Technology Policy, Japan] Press Release

EVENTS
NEW Copenhagen Bioscience Conferences – The Stem Cell Niche: Development and Disease
June 25-27, 2012
Copenhagen, Denmark

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Embryonic Stem Cell Biology Technician (Kymab Ltd.)

Postdoctoral Position – Department of Biomedical Engineering (Tsinghua University School of Medicine)

Stem Cell Biology Group Leader (Beike Bio-Technology Research Institute)


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