Volume 7.13 | Apr 4

ESC & iPSC News 7.13, April 4, 2012
ESC & iPSC News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Mixture of Differentially Tagged Tol2 Transposons Accelerates Conditional Disruption of a Broad Spectrum of Genes in Mouse Embryonic Stem Cells
Investigators show that transcriptionally silent genes in embryonic stem cells are severely underrepresented among the randomly trapped genes in the current international knockout mouse project. [Nucleic Acids Res] Abstract

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PUBLICATIONS (Ranked by Impact Factor of the Journal)
Migration Inhibitory Factor Produced by Bone Marrow-Derived Macrophages Contributes to Teratoma Progression After Embryonic Stem Cell Transplantation
Researchers investigated the effects of the microenvironment on stem cell growth and teratoma development using undifferentiated embryonic stem cells. [Cancer Res] Abstract

Neural Stem Cells Directly Differentiated from Partially Reprogrammed Fibroblasts Rapidly Acquire Gliogenic Competency
Researchers concluded that the directly induced neural stem cells were derived from partially reprogrammed cells, because dissociated ESCs/iPSCs did not form neurospheres in this culture condition. [Stem Cells] Abstract

Overexpression of TIMP-1 in Embryonic Stem Cells Attenuates Adverse Cardiac Remodeling Following Myocardial Infarction
The present study evaluates whether transplanted mouse embryonic stem cells overexpressing TIMP-1, an anti-apoptotic and anti-fibrotic protein, can enhance cardiac myocyte differentiation, inhibit native cardiac myocyte apoptosis, reduce fibrosis, and improve cardiac function in the infarcted myocardium. [Cell Transplant] Abstract

Expression of the 49 Human ATP Binding Cassette (ABC) Genes in Pluripotent Embryonic Stem Cells and in Early- and Late-Stage Multipotent Mesenchymal Stem Cells: Possible Role of ABC Plasma Membrane Transporters in Maintaining Human Stem Cell Pluripotency
Scientists performed a sensitive qRT-PCR analysis of ABC gene expression in embryonic stem cells (hESCs), bone marrow-derived mesenchymal stem cells (hMSCs) and hESC-derived hMSCs. [Cell Cycle] Abstract

Maxadilan Prevents Apoptosis in iPS Cells and Shows No Effects on the Pluripotent State or Karyotype
Researchers investigated the expression of pituitary adenylate cyclase-activating polypeptide type I receptor in human induced pluripotent stem (iPS) cells by reverse transcriptase polymerase chain reaction and western blot analysis. [PLoS One] Abstract

One-Step Derivation of Mesenchymal Stem Cell (MSC)-Like Cells from Human Pluripotent Stem Cells on a Fibrillar Collagen Coating
The present study reports a new method to rapidly derive MSC-like cells from human embryonic stem cells and human induced pluripotent stem cells, in one step, based on culturing the cells on thin, fibrillar, type I collagen coatings that mimic the structure of physiological collagen. [PLoS One] Abstract

Human Embryonic Stem Cells Differentiated to Lung Lineage-Specific Cells Ameliorate Pulmonary Fibrosis in a Xenograft Transplant Mouse Model
The aim of this study was to differentiate human embryonic stem cells into lung epithelial lineage-specific cells as the first step in the development of cell-based strategies to repair lung injury in the bleomycin mouse model of idiopathic pulmonary fibrosis. [PLoS One] Abstract

All-Trans-Retinoid Acid Induces the Differentiation of Encapsulated Mouse Embryonic Stem Cells into GABAergic Neurons
The goal of this work was to examine the generation of GABAergic neurons from mouse embryonic stem cells by comparing an embryoid body-based methodology versus a hydrogel-based encapsulation protocol that involves the use of all-trans-retinoid acid. [Differentiation] Abstract

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INDUSTRY NEWS
Canada and Japan Establish New Research Partnership
The Canadian Institutes of Health Research and the Japan Science and Technology Agency recently signed a partnership agreement to fund joint research projects on the epigenetics of stem cells. [Canadian Institutes of Health Research] Press Release

REMEDI Announce Collaborations with Chinese Universities
The Regenerative Medicine Institute (REMEDI) has signed collaborative agreements with the Shanghai Institute for Pediatric Research and the Tangdu Neurosurgery & Neurology Hospital. The agreement will see REMEDI work closely with both Chinese partners in a number of research areas and will facilitate student and researcher exchange between Galway and China. [The Regenerative Medicine Institute] Press Release

Cellular Dynamics Expands Distribution Agreement with iPS Academia Japan, Inc. to Include Distribution of iCell Neurons and iCell Endothelial Cells in Japan
Cellular Dynamics International, Inc. announced an expansion of its existing distribution agreement with iPS Academia Japan, Inc. to include iCell® Neurons and iCell Endothelial Cells. [Cellular Dynamics International, Inc.] Press Release
POLICY NEWS
Canadian Budget Hits Basic Science
Canada’s latest budget will slash spending on the environment and push for more collaboration between basic researchers and industry. [Canadian Government, Canada] Press Release

House Science Panel Examines Public-Access Policies
The debate over public access got an airing before a House Science Committee panel. Witnesses weighed in on whether the government should require research papers describing federally funded work be freely available. [House Science Committee, United States] Press Release

Senate Panel Questions NIH’s 2013 Budget Plan
A Senate spending panel gently probed the National Institutes of Health (NIH) leaders about their budget plan for next year, including how they would find more funding for research on Alzheimer’s disease. [National Institutes of Health, United States] Press Release
EVENTS
NEW Select Biosciences – Bioprocessing & Stem Cells Europe
June 27-28, 2012
London, United Kingdom

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Embryonic Stem Cell Biology Technician (Kymab Ltd.)

Postdoctoral Position – Department of Biomedical Engineering (Tsinghua University School of Medicine)

Stem Cell Biology Group Leader (Beike Bio-Technology Research Institute)


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