Volume 7.24 | Jun 20

ESC & iPSC News 7.24 June 20, 2012
ESC & iPSC News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Self-Organized Retinal Tissue from Human Embryonic Stem Cells
Researchers showed that human embryonic stem cells (hESCs) exhibit a capacity for generating self-organized, complex tissue structures with their report of an hESC-derived optic cup. The report also describes the group’s development of a cryopreservation technology capable of freezing these retinal tissues intact. [Press release from the RIKEN Center for Developmental Biology discussing online prepublication in Cell Stem Cell] Press Release | Abstract

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PUBLICATIONS (Ranked by impact factor of the journal)

Protein Kinase A Determines Timing of Early Differentiation through Epigenetic Regulation with G9a
Underlying mechanisms regulating differentiation timing are fully unknown. Here, scientists show a molecular mechanism determining differentiation timing from mouse embryonic stem cells. [Cell Stem Cell] Abstract

Sirt1, p53 and p38MAPK Are Crucial Regulators of Detrimental Phenotypes of ESCs with Max Expression Ablation
Investigators showed that Sirt1, p53 and p38MAPK are crucially involved in the detrimental phenotype of Max-null embryonic stem cells (ESCs). Moreover, their analyses revealed that these proteins are involved at varying levels to one another in the hierarchy of the pathway leading to cell death in Max-null ESCs. [Stem Cells] Abstract

miR-138 Promotes Induced Pluripotent Stem Cell Generation through the Regulation of the p53 Signaling
Researchers found that the ectopic expression of miR-138 significantly improved the efficiency of induced pluripotent stem (iPS) cell generation via Oct4, Sox2 and Klf4, with or without c-Myc, without sacrificing the pluripotent characteristics of the generated iPS cells. [Stem Cells] Abstract

E-Cadherin and, in Its Absence, N-Cadherin Promotes Nanog Expression in mES Cells via STAT3 Phosphorylation
The authors showed that E-cadherin promotes Klf4 and Nanog transcript and protein expression in mouse embryonic stem (mES) cells via STAT3 phosphorylation and that β-catenin, and its binding region in E-cadherin, is required for this function. [Stem Cells] Abstract

Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy
Researchers showed that induced pluripotent stem cell (iPSC) lines generated from two Type I spinal muscular atrophy (SMA) subjects recapitulate the disease phenotype and generate significantly fewer motor neurons at later developmental time periods in culture compared to two separate control subject iPSC lines. [PLoS One] Full Article | Press Release

Screening of Human Pluripotent Stem Cells Using CGH and FISH Reveals Low-Grade Mosaic Aneuploidy and a Recurrent Amplification of Chromosome 1q
Investigators applied fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) for the screening of pluripotent stem cells, which enabled them to identify chromosomal abnormalities in stem cell genomes with better resolution. They studied three human embryonic stem cell lines and two human induced pluripotent cell lines over long-term culture. [Eur J Hum Genet] Abstract

Endogenous Production of Fibronectin Is Required for Self-Renewal of Cultured Mouse Embryonic Stem Cells
Researchers showed that the ubiquitous extracellular matrix protein fibronectin is required for self-renewal decisions by cultured mouse embryonic stem cells. [Exp Cell Res] Abstract

Chromosome Dynamic Changes in Two Cultured Chinese Human Embryonic Stem Cell Lines: Single Nucleotide Polymorphism, Copy Number Variation and Loss of Heterozygosity
Two Chinese human embryonic stem cell lines, Zh1 and Zh21, were incubated over a long period. The researchers observed and compared the gene stability in the passage numbers 20, 17 for Zh1 cell line and passage numbers 27, 60, 68 for Zh21 cell line. [J Cell Biochem] Abstract

Characterization and Comparison of Embryonic Stem Cell-Derived KDR + Cells with Endothelial Cells
Endothelial cells were induced from human embryonic stem cell lines and their biological characteristics were analyzed and compared with both cord blood endothelial progenitor cells and human umbilical vein endothelial cells in vitro. [Microvasc Res] Abstract

Histone Modifications and Lamin A Regulate Chromatin Protein Dynamics in Early Embryonic Stem Cell Differentiation
Data provides mechanistic insights into the epigenetic pathways that are responsible for chromatin plasticity in embryonic stem cells, and indicate that the genome’s epigenetic state modulates chromatin plasticity and differentiation potential of embryonic stem cells. [Nat Commun] Abstract

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INDUSTRY NEWS

Six New U-M Stem Cell Lines Now Publicly Available to Help Researchers Find Treatments for Disease
Six new human embryonic stem cell lines derived at the University of Michigan (U-M) have just been placed on the U.S. National Institutes of Health’s registry, making the cells available for federally-funded research. [University of Michigan Health System] Press Release

Gov. Malloy Announces Award of $9.8 Million in Stem Cell Research Funding
Governor Dannel P. Malloy announced the awards of $9.8 million in stem cell research funds to 19 Connecticut-based researchers. The awards were made by the State of Connecticut Stem Cell Research Advisory Committee at its grant review meeting week. [State of Connecticut, Department of Public Health] Press Release

Osiris Receives Second Approval for Life-Saving Stem Cell Drug; Prochymal Granted Marketing Consent by New Zealand
Osiris Therapeutics, Inc. announced it has received consent from New Zealand to market its first-in-class stem cell therapy Prochymal® (remestemcel-L), for the treatment of acute graft-vs-host disease in children. With this decision New Zealand joins Canada, which last month became the world’s first internationally recognized regulatory authority to grant approval to a stem cell drug. [Osiris Therapeutics, Inc.]
Press Release

POLICY NEWS

European Parliament Urged to Continue Funding Research Using Embryonic Stem Cells
A coalition of leading funders of biomedical research and patients groups has issued a joint statement calling on the European Parliament to continue funding research using embryonic stem cells. [Wellcome Trust] Press Release

Senate Panel Approves $100 Million Boost for NIH in 2013
The Senate Appropriations Committee approved a $100 million raise for the National Institutes of Health (NIH) in the 2013 fiscal year which begins on 1 October. [Senate Appropriations Committee, United States]
Press Release

Budget Cuts Threaten Japanese Scientists’ Pay
Scientists in Japan are concerned about proposed belt-tightening measures that would decrease many public-sector salaries by up to 10% overnight and, some worry, have a long-term effect on the country’s efforts to maintain an internationally competitive research environment. [Japanese Government, Japan]
Press Release

New Open Access Journal Lets Scientists Publish ’til They Perish
An unusual new open access scientific journal is offering researchers the ultimate publishing flat rate: Pay $259 once and publish as many papers as you want for the rest of your life. The founders of PeerJ, a peer-reviewed biomedical journal unveiled, are aiming to start accepting submissions in August and to publish their first articles in December. [ScienceInsider] Press Release

EVENTS
NEW 4th International Conference on Stem Cells and Tissue Formation
July 18-20, 2012
Dresden, Germany

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Stem Cell Researcher (BioTalentum Ltd.)

Research Scientist (Shanghai Institute of Biochemistry and Cell Biology)

Postdoctoral Fellow – Mouse Embryogenesis (European Molecular Biology Laboratory)

Postdoctoral Position – Stem Cell Laboratory (University of California, San Diego)


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