Volume 7.29 | Jul 25

ESC & iPSC News 7.29 July 25, 2012
ESC & iPSC News
     In this issue: Publications | Industry News | Policy News | Events | Jobs
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TOP STORY
Transcription Factors ETS2 and Mesoderm Posterior 1 Transdifferentiate Human Dermal Fibroblasts into Cardiac Progenitors
Researchers showed that murine v-ets erythroblastosis virus E26 oncogene homolog 2 (ETS2) has a critical role in directing cardiac progenitors during cardiopoiesis in embryonic stem cells. They then used lentivirus-mediated forced expression of human ETS2 to convert normal human dermal fibroblasts into replicative cells expressing the cardiac mesoderm marker KDR+. [Proc Natl Acad Sci USA] Abstract

Air-Liquid Interface Culture for Respiratory Research: Watch Q&A Video
PUBLICATIONS (Ranked by impact factor of the journal)

Hypoxic Priming of mESCs Accelerates Vascular-Lineage Differentiation through HIF1-Mediated Inverse Regulation of Oct4 and Vascular Endothelial Growth Factor
Scientists investigated whether a short exposure to hypoxia efficiently directed and promoted mouse embryonic stem cells (mESCs) to differentiate into vascular-lineage. [EMBO Mol Med] Abstract

Epigenetic Stability, Adaptability, and Reversibility in Human Embryonic Stem Cells
Investigators found that as an initial response to altered culture conditions, human embryonic stem cells change their transcription profile for hundreds of genes and their DNA methylation profiles for several genes outside the core pluripotency network. [Proc Natl Acad Sci USA] Abstract

Microfluidic Single Cell Analysis Show Porcine Induced Pluripotent Stem Cell-Derived Endothelial Cells Improve Myocardial Function by Paracrine Activation
Researchers aimed to successfully derive endothelial cells from porcine induced pluripotent stem cells and demonstrate their potential utility for the treatment of myocardial ischemia. [Circ Res] Abstract

Deficient DNA Damage Response and Cell Cycle Checkpoints Lead to Accumulation of Point Mutations in Human Embryonic Stem Cells
Findings demonstrated that, due to deficient DNA damage response, the modest nucleotide excision repair activity in human embryonic stem cells is insufficient to prevent increased mutagenesis. [Stem Cells] Abstract

DNA and Chromatin Modification Networks Distinguish Stem Cell Pluripotent Ground States
To understand the molecular basis of pluripotency, researchers analyzed the nuclear proteomes of mouse embryonic and epiblast stem cells to identify protein networks that regulate their respective pluripotent states. [Mol Cell Proteomics] Abstract | Full Article

Marked Hyperglycemia Attenuates Anesthetic Preconditioning in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes
To address the role of hyperglycemia in the inability of diabetic individuals to be preconditioned, scientists used human cardiomyocytes differentiated from induced pluripotent stem cells generated from patients with or without type 2 diabetes mellitus to investigate the efficacy of preconditioning in varying glucose conditions. [Anesthesiology] Abstract

Human Induced Pluripotent Stem Cells Differentiated into Chondrogenic Lineage via Generation of Mesenchymal Progenitor Cells
Researchers examined the chondrogenic differentiation capability of human induced pluripotent stem cells using a multistep culture method consisting of embryoid body (EB) formation, cell outgrowth from EBs, monolayer culture of sprouted cells from EBs, and three-dimensional pellet culture. [Stem Cells Dev] Abstract

Analysis of Blastocyst Culture of Discarded Embryos and Its Significance for Establishing Human Embryonic Stem Cell Lines
In establishing human embryonic stem cell lines (hESCs) with discarded embryos, researchers suggest that D3 non-pronucleus (0PN) or 1PN embryos with seven to nine blastomeres should be first selected, because they can improve high-quality blastulation rate which can increase the efficiency of hESC establishment. [J Cell Biochem] Abstract

Learn to Efficiently Induce Neural Progenitor Cells for Human ES cells and iPS cells: Training Course with Expert Instruction and Hands-On Practice

INDUSTRY NEWS

NIH Funds Development of Tissue Chips to Help Predict Drug Safety
Seventeen National Institutes of Health (NIH) grants are aimed at creating 3-D chips with living cells and tissues that accurately model the structure and function of human organs such as the lung, liver and heart. Once developed, these tissue chips will be tested with compounds known to be safe or toxic in humans to help identify the most reliable drug safety signals. [National Institutes of Health, United States]
Press Release

Shire’s Advanced BioHealing Renamed Shire Regenerative Medicine
Shire plc announced that Advanced BioHealing, Inc., which was acquired by Shire in 2011 as a wholly-owned subsidiary focused on regenerative medicine, has changed its name to Shire Regenerative Medicine, Inc. [Shire plc] Press Release

POLICY NEWS

Cuts Loom for US Science
Hanging over the effective decrease in support proposed by the House of Representatives is the ‘sequester’, a pre-programmed budget cut that research advocates say would starve US science-funding agencies. [House of Representatives, United States] Press Release

European Researchers Strive for a New ERA
A philosophy of persistence was on display at the signing ceremony for a joint statement and memorandum of understanding between the European Commission and key research organizations and funding bodies in the commission’s Berlaymont headquarters. The target of their tenacity and the subject of the signed documents was the long-held dream of enabling European researchers to easily move and conduct research across the European Union’s member states, a goal encapsulated by the notion of the so-called European Research Area (ERA). [European Commission, Europe] Press Release

EVENTS
NEW World iPS Cell Summit
October 31-November 1, 2012
Boston, United States

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Associate – Chemistry (STEMCELL Technologies, Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.)

Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Stem Cell Researcher (BioTalentum Ltd.)

Postdoctoral Research Position (University Lille 2 France)

Postdoctoral Position – Stem Cells (Children’s Hospital of Chicago Research Center)

Postdoctoral Fellow – Stem Cell Mechanobiology (National Institute for Materials Science)


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