Volume 7.34 | Aug 29

ESC & iPSC News 7.34 August 29, 2012
ESC & iPSC News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Researchers First to Grow Lung Cells Using Stem Cell Technology
New stem cell research paved the way towards individualized medicine for patients with cystic fibrosis and other lung diseases. The study is the first to successfully use stem cells to produce mature lung cells that could potentially be used to study the disease and test drugs. [Press release from The Hospital for Sick Children discussing online prepublication in Nature Biotechnology] Press Release | Abstract

Happy Birthday mTeSR™1! 5 years of Groundbreaking Research and Counting
PUBLICATIONS (Ranked by impact factor of the journal)

CDKL5 Ensures Excitatory Synapse Stability by Reinforcing NGL-1-PSD95 Interaction in the Postsynaptic Compartment and Is Impaired in Patient iPSC-Derived Neurons
Similarly to rodent neurons, iPSC-derived neurons from patients with cyclin-dependent kinase-like 5 (CDKL5) mutations exhibit aberrant dendritic spines, thus suggesting a common function of CDKL5 in mice and humans. [Nat Cell Biol] Abstract

Modeling Supravalvular Aortic Stenosis Syndrome Using Human Induced Pluripotent Stem Cells
Researchers report the development of a human induced pluripotent stem cell line from a patient with supravalvular aortic stenosis caused by the premature termination in exon 10 of the elastin gene due to an exon 9 4-nucleotide insertion. [Circulation] Abstract

Extracellular Matrix Promotes Highly Efficient Cardiac Differentiation of Human Pluripotent Stem Cells: The Matrix Sandwich Method
Scientists sought to develop a more effective protocol for cardiac differentiation of human pluripotent stem cells by using extracellular matrix in combination with growth factors known to promote cardiogenesis. [Circ Res] Abstract

Mitotically Inactivated Embryonic Stem Cells Can Be Utilized as an In Vivo Feeder Layer to Nurse Damaged Myocardium following Acute Myocardial Infarction: A Pre-Clinical Study
The authors aimed to determine if irradiated embryonic stem cells improve post ischemic cardiac function without adverse consequences. [Circ Res] Abstract

Histone Deacetylase 1 Deficiency Impairs Differentiation and Electrophysiological Properties of Cardiomyocytes Derived from Induced Pluripotent Cells
Researchers analyzed how the loss of a key chromatin modifying enzyme, histone deacetylase 1, affects early and cardiovascular differentiation of both embryonic stem and induced pluripotent stem cells. They also investigated potential differences between these two cell types when differentiation is induced. [Stem Cells] Abstract

A Shrna Functional Screen Reveals Non-Metastatic Cell Signalings Are Crucial for Embryonic Stem Cell Renewal
Revealing the underlying mechanism of embryonic stem cell (ESC) characteristics is important for the application of ESCs in clinical medicine. Investigators performed systematic functional screen in mouse ESCs with 4801 shRNAs that target 929 kinases and phosphatases. [Stem Cells] Abstract

3-O-Sulfated Heparan Sulfate Recognized by the Antibody HS4C3 Contribute to the Differentiation of Mouse Embryonic Stem Cells via Fas Signaling
Researchers present the first demonstration that activation of Fas signaling is mediated by an increase in the HS4C3-binding epitope and indicates a novel signaling pathway for differentiation in mouse embryonic stem cells. [PLoS One] Full Article

Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells
Researchers demonstrated that human embryonic stem cells and induced pluripotent stem cells differentiate directly into advanced male germ cell lineages, including postmeiotic, spermatid-like cells, in vitro without genetic manipulation. [Cell Rep] Abstract | Press Release

Near Singapore? Attend our Human ES Cells and iPS Cells Training Course. October 4 - 5, 2012 | National Heart Centre, Singapore

NEW! REVIEWS
Based on your feedback, we’ve added a Reviews section to ESC & iPSC News
Stem Cell-Derived Cell Cultures and Organoids for Protozoan Parasite Propagation and Studying Host-Parasite Interaction
Possibilities to study the biology of human protozoan parasites and their interaction with the host remain severely limited, either because of non-existent or inappropriate animal models or because parasites cannot even be cultured in vitro due to strict human-host specificity or physiology. Here scientists discussed the prospects of using induced pluripotent stem cell-derived culture systems including organoids as a strategy to address many of these experimental bottlenecks. [Int J Med Microbiol] Abstract

World iPS Cell Summit
INDUSTRY NEWS

The Maryland Stem Cell Research Commission: Public Statement
The Maryland Stem Cell Research Commission is pleased with the opinion issued by the U.S. Court of Appeals for the District of Columbia Circuit in Sherley, et al. vs. Sebelius, et al. regarding the federal funding of human embryonic stem cell research. The position taken by the Court allows this promising stem cell research to progress in the U.S., paving the way for groundbreaking discoveries that could ameliorate a multitude of debilitating diseases and disorders. [Maryland Stem Cell Research Fund] Press Release

Anne-Marie Duliege Appointed to Governing Board of California’s Stem Cell Agency
Anne-Marie Duliege, MD, Chief Medical Officer of Affymax Inc., has been appointed to the Independent Citizens Oversight Committee, the governing board of California’s stem cell agency, the California Institute for Regenerative Medicine. [California Institute for Regenerative Medicine] Press Release

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POLICY NEWS

Republican Spending Plan Casts Shadow on Science
As chairman of the House of Representatives budget committee in the current Congress, Paul Ryan has crafted a federal spending plan that contrasts sharply with that of President Barack Obama. If carried out, Ryan’s plan could cut spending on non-defense-related research and development by 5%, or $3.2 billion, below the fiscal-year 2012 budget. [American Association for the Advancement of Science, United States] Press Release

Ego vs. Efficiency at the U.S. National Science Board
A new U.S. law that exempts 169 presidential appointees from having to be confirmed by the Senate has ruffled feathers at the National Science Board. The 24-member board is now part of that new category of people who can take office immediately after they say “yes” to an invitation from the White House. [National Science Board, United States] Press Release

NIH’s Millionaires to Get Extra Scrutiny
The National Institutes of Health (NIH) plans to give extra scrutiny to proposals from researchers receiving more than $1 million a year in direct support from grants, and may not fund them if the research overlaps with what they’re already doing. [National Institutes of Health, United States] Press Release

EVENTS
NEW Stem Cells 2012
October 10-12, 2012
Mumbai, India

Visit
our events page to see a complete list of events in the ESC & iPSC community.
JOB OPPORTUNITIES

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Stem Cell Researcher (BioTalentum Ltd.)

Postdoctoral Research Position (University Lille 2 France)

Postdoctoral Position – Biomedical Engineering (School of Medicine, Tsinghua University)

Postdoctoral Position – Molecular Biology (Faculty of Informatics, Masaryk University)

Research Associate – Quality Assurance (University of California)


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