ESC & iPSC News

ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).

Txnip Regulates the Oct4-Mediated Pluripotency Circuitry via Metabolic Changes upon Differentiation

[Cellular and Molecular Life Sciences] Researchers revealed the novel functions of mouse Txnip in cellular reprogramming and differentiation onset by involving in glucose-mediated histone acetylation and the regulation of Oct4, which was a fundamental component of the molecular circuitry underlying pluripotency.

Precise and Scalable Self-Organization in Mammalian Pseudo-Embryos

[Nature Structural & Molecular Biology] Scientists investigated how precise and reproducible patterns of gene expression emerged in mammals by using gastruloids, a three-dimensional in vitro model for early mammalian development.

PRODH Safeguards Human Naive Pluripotency by Limiting Mitochondrial Oxidative Phosphorylation and Reactive Oxygen Species Production

[EMBO Reports] Investigators reported that, proline dehydrogenase (PRODH), a mitochondria-localized proline metabolism enzyme, was dramatically upregulated in naive hESCs compared to their primed counterparts.

H2AK119ub1 Differentially Fine-Tunes Gene Expression by Modulating Canonical PRC1- and H1-Dependent Chromatin Compaction

[Molecular Cell] Researchers revealed that H2AK119ub1 had two distinct roles in gene expression, through differentially modulating chromatin compaction mediated by canonical polycomb repressive complex 1 (PRC1) and the linker histone H1.

ATG5 Nonautophagically Regulates Inflammation and Differentiation in Mouse Embryonic Stem Cells

[Autophagy] Investigators demonstrated that macroautophagy/autophagy-related protein ATG5 inhibited the inflammatory response of mouse ESCs by promoting the degradation of BTRC/β-TrCP1 and further the downregulation of NFKB/NF-κB signaling.

Di-n-Butyl Phthalate Promotes the Neural Differentiation of Mouse Embryonic Stem Cells through Neurogenic Differentiation 1

[Environmental Pollution] Researchers focused on the characterization of the genetic traits and alterations in pluripotency/stemness triggered by phthalate ester derivatives. They reported the abilities of ESCs regarding proliferation, cell-cycle control, and neural ectoderm differentiation.

Improving Cardiac Differentiation of Human Pluripotent Stem Cells by Targeting Ferroptosis

[Regenerative Therapy] Scientists increased the efficiency of generating cardiomyocytes from hPSCs. They identified cell death as a detrimental factor during this initial stage of in vitro cardiomyocyte differentiation.

Lessons from Inducible Pluripotent Stem Cell Models on Neuronal Senescence in Aging and Neurodegeneration

[Nature Aging] The authors review the evidence of cellular senescence in neuronal aging and disease, discuss hPSC-based model systems used to investigate neuronal senescence and propose a panel of cellular and molecular hallmarks to characterize senescent neurons.

Emerging Human Pluripotent Stem Cell-Based Human–Animal Brain Chimeras for Advancing Disease Modeling and Cell Therapy for Neurological Disorders

[Neuroscience Bulletin] Investigators discuss recent advances in the generation and applications of using human–animal chimeric brain models for the study of neurological disorders, including disease modeling and cell therapy.

Gladstone to Expand Stem Cell Research Capabilities with Multi-Million Dollar Regenerative Medicine Grant

[Gladstone Institutes] Powered by a $4 million grant from the California Institute for Regenerative Medicine, Gladstone will expand its capabilities even further by establishing a center for stem cell disease modeling and CRISPR drug screening.

Sarcomeric Tropomyosin Expression during Human iPSC Differentiation into Cardiomyocytes

[Cytoskeleton] During the differentiation time course, researchers harvested cells on days 0, 5, 10, 15, and 20 to analyze for various sarcomeric tropomyosin (TPM) transcripts by qRT-PCR and for sarcomeric TPM proteins using two-dimensional Western blot with sarcomeric TPM-specific CH1 monoclonal antibody followed by mass spectra analyses.

The Role of Smarcad1 in Retroviral Repression in Mouse Embryonic Stem Cells

[Mobile DNA] Investigators used Moloney murine leukemia virus (MLV) to explore the role of Smarcad1 in retroviral silencing in ESCs. They showed that Smarcad1 was immediately recruited to the MLV provirus.

Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.

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