Volume 8.47 | Nov 27

ESC & iPSC News 8.47 November 27, 2013
ESC & iPSC News
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Enhanced Telomere Rejuvenation in Pluripotent Cells Reprogrammed via Nuclear Transfer Relative to Induced Pluripotent Stem Cells
Although somatic cell nuclear transfer and induction of pluripotency (to form iPSCs) are both recognized reprogramming methods, there has been relatively little comparative analysis of the resulting pluripotent cells. Investigators examined the capacity of these two reprogramming approaches to rejuvenate telomeres using late-generation telomerase-deficient mice that exhibit telomere dysfunction and premature aging. [Cell Stem Cell] Abstract | Graphical Abstract
Efficiently Expand hPSC-Derived NPCs Without Loss of Multipotency: STEMdiff™ Neural Progenitor Medium
PUBLICATIONS (Ranked by impact factor of the journal)
Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species
The authors applied Cre-loxP genetic fate mapping to skeletal muscle during limb regeneration in two salamander species, Notophthalmus viridescens (newt) and Ambystoma mexicanum (axolotl). They found that myofiber dedifferentiation is an integral part of limb regeneration in the newt, but not in axolotl. [Cell Stem Cell] Abstract | Graphical Abstract | Press Release

Tsix RNA and the Germline Factor, PRDM14, Link X Reactivation and Stem Cell Reprogramming
Investigators examined the role of the long noncoding Tsix RNA and the germline factor, PRDM14. In blastocysts, X chromosome reactivation (XCR) is perturbed by mutation of either Tsix or Prdm14. In induced pluripotent stem cells (iPSCs), XCR is disrupted only by PRDM14 deficiency, which also affects iPSC derivation and maintenance. [Mol Cell] Abstract | Graphical Abstract

c-Met-Dependent Multipotent Labyrinth Trophoblast Progenitors Establish Placental Exchange Interface
Scientists identified an Epcamhi labyrinth trophoblast progenitor in mouse placenta that at a clonal level generates all labyrinth trophoblast subtypes, syncytiotrophoblasts I and II, and sinusoidal trophoblast giant cells. [Dev Cell] Full Article | Graphical Abstract | Press Release

Design and Formulation of Functional Pluripotent Stem Cell-Derived Cardiac Microtissues
The authors used computational modeling of tissue contraction and assembly mechanics in conjunction with microfabricated constraints to guide the design of aligned and functional 3D human pluripotent stem cell-derived cardiac microtissues that they term cardiac microwires. [Proc Natl Acad Sci USA]
Abstract | Press Release

Differentiation-Defective Phenotypes Revealed by Large-Scale Analyses of Human Pluripotent Stem Cells
Investigators examined the gene expression and DNA methylation of 49 human induced pluripotent stem cells and 10 human embryonic stem cells and found overlapped variations in gene expression and DNA methylation in the two types of human pluripotent stem cell lines. [Proc Natl Acad Sci USA] Abstract

Human iPSC Models of Neuronal Ceroid Lipofuscinosis Capture Distinct Effects of TPP1 and CLN3 Mutations on the Endocytic Pathway
Researchers report successful reprogramming of patient fibroblasts into induced pluripotent stem cells (iPSCs) for the two most common neuronal ceroid lipofuscinosis (NCL) subtypes: classic late-infantile NCL, caused by TPP1(CLN2) mutation, and juvenile NCL, caused by CLN3 mutation. [Hum Mol Genet] Abstract

Three-Dimensional Filamentous Human Diseased Cardiac Tissue Model
Scientists developed an in vitro model of three-dimensional human cardiac tissue by populating synthetic filamentous matrices with cardiomyocytes derived from healthy wild-type volunteer and patient-specific long QT syndrome type 3 induced pluripotent stem cells to mimic the condensed and aligned human ventricular myocardium. [Biomaterials] Abstract

Epithelial-Mesenchymal Transition Delayed by E-Cad to Promote Tissue Formation in Hepatic Differentiation of Mouse Embryonic Stem Cells In Vitro
Researchers examined the role of epithelial-mesenchymal transition regulated by epithelial cadherin (E-cad) expression in hepatic tissue formation from embryonic stem cells. [Stem Cell Dev] Abstract

SILAC Proteomics of Planarians Identifies Ncoa5 as a Conserved Component of Pluripotent Stem Cells
Investigators developed an in vivo stable isotope labeling by amino acids in cell culture (SILAC) protocol in planarians to identify proteins that are enriched in planarian stem cells. [Cell Rep]
Full Article | Graphical Abstract

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Clinical Grade iPS Cells: Need for Versatile Small Molecules and Optimal Cell Sources
The authors provide a critical overview of methods and cell sources available for induced pluripotent stem (iPS) cell production. They think the review will be a useful resource for researchers who aim to develop small molecules for speeding up the journey of iPS cells from the laboratory to the clinic. [Chem Biol] Full Article

Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field.

Enter to Win: Free ISCT 2014 Conference Registration in Paris, France!
NYSCF and NIH Create Cell Models of Rare and Undiagnosed Diseases
In what is anticipated to be a major step forward for rare disease research, The New York Stem Cell Foundation (NYSCF) Research Institute is partnering with the National Institutes of Health (NIH) Undiagnosed Disease Program (UDP). NYSCF scientists will generate stem cell lines from 100 patients in the UDP and collaborate with UDP researchers to better understand and potentially treat select rare diseases. [EurekAlert] Press Release

New Stem Cell Platform Technology Recognized with Patent Award
Stem cell therapeutics provider Parcell Laboratories announced that the U.S. Patent and Trademark Office has issued Patent No. 8,574,567 entitled “Multipotent Stem Cells and Uses Thereof”. The newly issued patent concerns the Early Lineage Adult stem cell, and relates to providing an isolated population of stem cells that exist in the synovial fluid, blood, and other tissues in the body, and related therapeutic methods. [Marketwire L.P.] Press Release

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European Parliament Approves Horizon 2020 Funding Plan
The European Parliament has formally approved Horizon 2020, the European Union’s funding program for research and innovation for 2014 through 2020. This leaves one formal step to go before the program’s actual rollout. [ScienceInsider] Editorial

Communist Party Takes Aim at Elite Scientists
Long considered the capstone of a scientific career in China, election to the Chinese Academy of Sciences (CAS) confers so much prestige on those anointed that organizations often try to recruit CAS members or reward their own with a guarantee of lifetime employment. But China’s Communist Party has ordered a reform of China’s academy membership system that may be aimed at curtailing privileges for academicians, or yuanshi. [ScienceInsider] Editorial
NEW Tissue Engineering Congress 2014
June 2-4, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the ESC & iPSC community.
NEW Postdoctoral Position – RNA and Stem Cell Biology (Cancer Research Centre of Lyon)

Research Associate – Stem Cells & Regenerative Medicine (King’s College London)

Postdoctoral Fellow – Liver Tissue Engineering (Harvard Medical School)

PhD Studentship – Wnt-Signaling and Stem Cell Biology (University of Amsterdam)

Postdoctoral Position – Stem Cells and Epigenetics (Icahn School of Medicine at Mount Sinai)

Assistant Director (Wake Forest Institute for Regenerative Medicine)

Postdoctoral Position – Human Stem Cells (Sabine Costagliola-ULB)

Faculty Position – Stem Cell Biology (University of Notre Dame / College of Science)

Postdoctoral Associate – Human and Mouse Stem Cell Biology, Pancreatic and Liver Specification and In Vitro Disease Modeling (Baylor College of Medicine)

Postdoctoral Research Fellow – Stem Cells (Bioprocessing Technology Institute)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

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