Volume 8.50 | Dec 18

Newsletter Issue
ESC & iPSC News 8.50 December 18, 2013
ESC & iPSC News
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TOP STORY
A Big Step for Cell Reprogramming
A group of researchers have discovered a faster and more efficient mechanism for reprogramming induced pluripotent stem cells (iPS). The discovery decreases the time needed for cell reprogramming from a couple of weeks to a few days and reveals new information on the reprogramming process for iPS cells and their potential medical applications. [Press release from the Centre for Genomic Regulation discussing online prepublication in Nature] Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Directing Human Embryonic Stem Cell Differentiation towards a Renal Lineage Generates a Self-Organizing Kidney
Researchers successfully directed the differentiation of human embryonic stem cells through posterior primitive streak and intermediate mesoderm under fully chemically defined monolayer culture conditions using growth factors used during normal embryogenesis. [Nat Cell Biol] Abstract | Press Release

Characterizing the Strand-Specific Distribution of Non-CpG Methylation in Human Pluripotent Cells
With the divide-and-compare strategy, scientists showed that CHG and CHH methylation are not intrinsically different in human embryonic stem cells and induced pluripotent stem cells. [Nucleic Acids Res] Abstract

The Effects of Artificial E-Cadherin Matrix-Induced Embryonic Stem Cell Scattering on Paxillin and RhoA Activation via α-Catenin
Investigators aimed to clarify the effect of cell scattering on the regulation of Rho family GTPases Rac1 and RhoA as well as paxillin. Allowing embryonic stem cells to spread and scatter on a synthetically designed E-cadherin substratum causes phosphorylation of paxillin on consensus phosphorylation sites leading to activation of Rac1 and inactivation of RhoA. [Biomaterials] Abstract

The Polycomb Protein Ezh2 Impacts on iPS Cell Generation
The authors investigated the impact of Ezh2, a core subunit of Polycomb repressive complex 2, on generation of induced pluripotent stem (iPS) cells. They found that Ezh2 expression is induced during iPS cell generation and iPS cells contain high levels of Ezh2 mRNA and protein. [Stem Cells Dev] Abstract

Induced Pluripotent Stem Cells from Patients with Human Fibrodysplasia Ossificans Progressiva Show Increased Mineralization and Cartilage Formation
Researchers created human induced pluripotent stem cells derived from normal and fibrodysplasia ossificans progressiva dermal fibroblasts by two separate methods, retroviral integration or integration-free episomal vectors. [Orphanet J Rare Dis] Abstract | Full Article

Recellularization of Well Preserved Acellular Kidney Scaffold Using Embryonic Stem Cells
After infusion of whole-kidney scaffolds with murine embryonic stem cells through the renal artery, and pressure-controlled perfusion with recirculating cell medium for 24 and 72 hours, seeded cells were almost completely retained into the organ and uniformly distributed in the vascular network and in glomerular capillaries without major signs of apoptosis. [Tissue Eng Part A] Abstract

Improving Embryonic Stem Cell Expansion through the Combination of Perfusion and Bioprocess Model Design
To characterize nutritional requirements, the expansion of undifferentiated murine embryonic stem cells encapsulated in hydrogels was performed in batch and perfusion cultures using bioreactors. [PLoS One]
Full Article

Synthetic Niches for Differentiation of Human Embryonic Stem Cells Bypassing Embryoid Body Formation
Scientists describe the application of highly porous polymer scaffolds as synthetic stem cell niches. Bypassing the embryoid body formation step, these scaffolds are capable of three-dimensional culture of undifferentiated human embryonic stem cells and subsequent directed differentiation into three primary germ layers. [J Biomed Mater Res B Appl Biomater] Abstract

In Vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
Researchers hypothesized that the reprogramming of somatic cells towards pluripotency could be achieved in vivo by gene transfer of reprogramming factors. In order to efficiently reprogram cells in vivo, high levels of the Yamanaka transcription factors need to be expressed at the target tissue. [J Vis Exp]
Full Article | Press Release

Small Molecule-Mediated Directed Differentiation of Human Embryonic Stem Cells toward Ventricular Cardiomyocytes
By combining small molecules and growth factors, scientists developed a fully chemically defined, directed differentiation system to generate ventricular-like cardiomyocytes from human embryonic stem cells and induced pluripotent stem cells with high efficiency and reproducibility. [Stem Cells Transl Med] Abstract

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REVIEWS
The Immunogenicity of Cells Derived from Induced Pluripotent Stem Cells
Recent studies revealing the abnormal epigenetics, genomic stability and immunogenicity of induced pluripotent stem cells (iPSCs) have raised safety concerns over iPSC-based therapy. Recent findings related to the immunogenicity of iPSC derivatives are summarized. [Cell Mol Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field.

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INDUSTRY NEWS
Stem Cell Agency Board Funds More than $61 Million in Cancer, Sickle Cell Disease and Vision Loss and Sets New Focus
Reflecting the progress being made in moving the most promising therapies out of the lab and into clinical trials, the state stem cell agency, the California Institute for Regenerative Medicine, voted to approve $61 million in funding for its third round of Disease Team awards. [California Institute for Regenerative Medicine]
Press Release

Advanced Cell Technology Announces Release of New Edition of Definitive Resource in Tissue Engineering
Advanced Cell Technology, Inc. announced its chief scientific officer, Robert Lanza, M.D., and Robert Langer, Sc.D. have released the fourth edition of “Principles of Tissue Engineering.” The 1936-page volume includes contributions from 20 members of the National Academies of Science, Engineering, and Institute of Medicine, as well as dozens of pioneers in the fields of stem cells, tissue engineering, and regenerative medicine. [Advanced Cell Technology] Press Release

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POLICY NEWS
Medics Should Plan Ahead for Incidental Findings
Doctors, researchers and companies should expect to find information they were not looking for in genetic analyses, imaging scans and other tests, concludes a report from the US Presidential Commission for the Study of Bioethical Issues. Moreover, medics and investigators should discuss with patients and research volunteers how these potentially serious findings will be handled before the tests are carried out. [Nature News] Editorial

US Budget Deal Would Ease Science Agencies’ Pain
The US Congress has announced that it is close to a deal on government spending that would, for the next two years, eliminate the across-the-board cuts known as sequestration. The deal offers a respite from the partisan battles over government spending that culminated in October with a 16-day government shutdown, and it would give a budgetary boost to science agencies in 2014, rather than another set of cuts. [Nature News] Editorial
 
EVENTS
NEW 12th Annual International Society for Stem Cell Research Meeting
June 18-21, 2014
Vancouver, Canada

Visit our events page to see a complete list of events in the ESC & iPSC community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Position – Epigenetic Regulation of Heart Formation Using Human ES & iPS Cells (University of Pittsburgh)

Postdoctoral Associate – Stem Cell Biology (State University of New York)

Postdoctoral Fellow – Cardiovascular Tissue Engineering (Stanford University School of Medicine)

Clinical MD – Clinical Development Program for Oncology and Autoimmune Diseases (Immunomedics, Inc.)

Chief Medical Officer – Novel Therapeutics in Oncology and Autoimmune Disease (Immunomedics, Inc.)

Postdoctoral Position – RNA and Stem Cell Biology (Cancer Research Centre of Lyon)

Postdoctoral Fellow – Liver Tissue Engineering (Harvard Medical School)

Postdoctoral Position – Stem Cells and Epigenetics (Icahn School of Medicine at Mount Sinai)

Assistant Director (Wake Forest Institute for Regenerative Medicine)

Postdoctoral Position – Human Stem Cells (Sabine Costagliola-ULB)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)


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