Volume 9.12 | Apr 2

ESC & iPSC News 9.12 April 2, 2014
ESC & iPSC News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
Scientists Break New Ground in Embryonic Stem Cells
Researchers have been able to make embryonic stem cells from adult mouse body cells using the cytoplasm of two-cell embryos that were in the “interphase” stage of the cell cycle. Scientists had previously thought the interphase stage – a later stage of the cell cycle – was incapable of converting transplanted adult cell nuclei into embryonic stem cells. [Press release from the Oregon Health & Science University discussing online prepublication in Nature] Press Release | Abstract
Enter to Win a Travel Award to ISSCR 2014
 
PUBLICATIONS (Ranked by impact factor of the journal)
Phenotypic Differences in hiPSC NPCs Derived from Patients with Schizophrenia
Researchers report that a significant fraction of the gene signature of schizophrenia (SZ) human-induced pluripotent stem cells (hiPSC)-derived neurons is conserved in SZ hiPSC neural progenitor cells (NPCs). [Mol Psychiatry] Full Article

The Retrovirus HERVH Is a Long Noncoding RNA Required for Human Embryonic Stem Cell Identity
Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Researchers report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. [Nat Struct Mol Biol] Abstract | Editorial

Directed Differentiation of Embryonic Origin-Specific Vascular Smooth Muscle Subtypes from Human Pluripotent Stem Cells
Investigators describe how human pluripotent stem cells can be differentiated into distinct populations of smooth muscle cell subtypes under chemically defined conditions. [Nat Protoc] Abstract

KAP1 Represses Differentiation-Inducible Genes in Embryonic Stem Cells through Cooperative Binding with PRC1 and Derepresses Pluripotency-Associated Genes
The changes in the transcriptome upon conditional KAP1 knockout in embryonic stem (ES) cells overlapped with the changes during embryoid body formation. KAP1 repressed differentiation-inducible genes and derepressed pluripotency-associated genes in ES cells. [Mol Cell Biol] Abstract

In Vitro Generation of Motor Neuron Precursors from Mouse Embryonic Stem Cells Using Mesoporous Nanoparticles
Differentiation of embryonic stem cells into motor neuron precursors involves factors and their repeated administration. Scientists investigated if delivery of factors loaded into mesoporous nanoparticles could be effective for stem cell differentiation in vitro. [Nanomedicine (Lond)] Abstract

A Comprehensive System for Generation and Evaluation of Induced Pluripotent Stem Cells Using piggyBac Transposition
Researchers describe a simple but comprehensive system for generating and evaluating induced pluripotent stem cells by single transfection of multiple piggyBac plasmid vectors encoding Tet-inducible polycistronic reprogramming factors, a pluripotent-cell-specific reporter, a constitutively active reporter, and a sperm-specific reporter. [PLoS One] Full Article

Robust, Microfabricated Culture Devices with Improved Control Over the Soluble Microenvironment for the Culture of Embryonic Stem Cells
The use of microfabricated systems combines good control over the cellular microenvironment with reduced use of resources in process optimization. Investigators describe a number of improvements to the design of the microfabricated system to significantly improve the control over shear stress and soluble factors, particularly dissolved oxygen. [Biotechnol J] Abstract

Simple Derivation of Transgene-Free iPS Cells by a Dual Recombinase Approach
Scientists describe a new approach for the simple derivation of transgene-free induced pluripotent stem (iPS) cells by the sequential use of two DNA recombinases, C31 Integrase and Cre, to control the genomic insertion and excision of a single, non-viral reprogramming vector. [Mol Biotechnol] Abstract

Intrastriatal Transplantation of Adenovirus-Generated Induced Pluripotent Stem Cells for Treating Neuropathological and Functional Deficits in a Rodent Model of Huntington’s Disease
Adult rats received a regimen of 3-nitropropionic acid (3-NP) to induce behavioral and neuropathological deficits that resemble Huntington’s disease. At 7, 21, and 42 days after the initiation of 3-NP or vehicle, the rats received intrastriatal bilateral transplantation of induced pluripotent stem cells. [Stem Cells Transl Med] Abstract

Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
 
REVIEWS
Rethinking Differentiation: Stem Cells, Regeneration, and Plasticity
Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated cell. [Cell] Full Article

Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field.
 
INDUSTRY NEWS
NeoStem Begins Research Collaboration for Treatment of Skin Wounds in Scleroderma
NeoStem, Inc. announced that it has signed an agreement for a research collaboration investigating the potential of very small embryonic-like stem cells in treating difficult to heal wounds in an animal model of scleroderma. [NeoStem, Inc.] Press Release

£3.5 Million Boost for Regenerative Medicine Research Programs
The Loughborough University-led Center for Doctoral Training in Regenerative Medicine has been awarded £3.5 million from the Engineering and Physical Sciences Research Council and the Medical Research Council to further its research programs in the fast-growing field of the healthcare industry. [Loughborough University]
Press Release

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POLICY NEWS
RIKEN Panel Finds Misconduct in Reprogrammed Stem Cell Papers
An investigating committee has concluded that falsification and fabrication mar two recent Nature papers reporting a new, simple way to reprogram mature cells into stem cells. The committee concluded that these acts constitute research misconduct, but it stopped short of calling for the papers to be retracted and will leave the question of disciplinary action to a separate committee. [ScienceInsider] Editorial

German University Tells Elsevier ‘No Deal’
In the latest skirmish between academia and publishers over the costs of academic journals, the University of Konstanz in Germany has broken off negotiations over a new licensing agreement with the scientific publisher Elsevier. The publisher’s prices are too high, said university Rector Ulrich Rüdiger in a statement, and the institution “will no longer keep up with this aggressive pricing policy and will not support such an approach.” [ScienceInsider] Editorial

UK Funders Get Tough on Privacy Breaches
Leading UK organizations that fund research have threatened to revoke the funding of scientists who determine the identities of participants in medical and genomic studies who had expressed a wish to remain anonymous. [Nature News] Editorial
 
EVENTS
NEW The 2014 Regenerative Medicine Event: Stem Cell Reprogramming
June 2, 2014
London, United Kingdom

Visit our events page to see a complete list of events in the ESC & iPSC community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow / Research Officer – Stem Cell Research (Bioprocessing Technology Institute)

NEW Research Associate – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Stem Cell Research (Washington University School of Medicine)

Postdoctoral Position – Embryonic Stem Cells and Chromatin Biology (University of Michigan)

Postdoctoral Position – TGFβ-Signaling Pathway in Embryonic Stem Cells (Tsinghua University)

Stem Cell Research Technician (Van Andel Research Institute)

Postdoctoral Position – Stem Cells and Epigenetics (Mount Sinai School of Medicine)

Director of GMP/GLP Quality Operations (University of Pennsylvania, Perelman School of Medicine)

Postdoctoral Position – Human Stem Cell Biology and Hematopoiesis (Johns Hopkins University School of Medicine)

Postdoctoral Positions – Stem Cells (CREI Stem Cells, SkolTech)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

Research Technologist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – PSC Biology and Bioengineering (STEMCELL Technologies Inc.)


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