Induced Pluripotent Stem Cells for Modeling of Pediatric Neurological Disorders|
The authors provide an overview of various gene delivery systems for generating induced pluripotent stem cells, the current state of modeling early-onset neurological disorders and the ultimate application of these in-vitro models in cell therapy through the correction of disease-specific mutations. [Biotechnol J]
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Researchers Slam Transparency ‘U-Turn’ at E.U. Medicines Agency|
Researchers are worried that the European Medicines Agency is backpedaling on its pledge to open clinical trials data to public scrutiny. Draft documents detailing how the agency plans to make such data available contains small print that may severely limit access and that constitutes a turnaround from earlier promises for openness, academics say. [ScienceInsider]
NIH to Require Sex-Reporting in Preclinical Studies
The US National Institutes of Health (NIH) will require grant applicants to report the sex of animals and cells used in preclinical studies. The shift could help to reveal differences in the ways that diseases affect males and females. [Nature News]
No Patent for Dolly the Cloned Sheep, Court Rules, Adding to Industry Jitters
Dolly the sheep enjoyed a brief and highly publicized life as the first mammal cloned from an adult cell before succumbing to lung disease in 2003 at age 6. But an attempt to patent Dolly, and lay commercial claim to animals produced by cloning, survived much longer. But that nearly 10-year-long saga also appears to have ended last week when a U.S. federal appeals court ruled against giving a patent to Dolly’s creators. [ScienceInsider]
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