Time-Lapse Study Reveals Bottlenecks in Stem Cell Expansion
Using pluripotent stem cells in therapies is currently hampered by the fact they can acquire genetic changes during prolonged culture which are non-random and resemble mutations in cancer cells. Researchers used time-lapse imaging of single human pluripotent stem cells to identify aspects of their behavior that restrict growth and would be targets for mutations that allow cells to grow more efficiently. [Press release from the University of Sheffield discussing online prepublication in Stem Cell Reports] Press Release|Video|Full Article |Graphical Abstract
Chromosome Instability in Mouse Embryonic Stem Cells
Culture conditions and long-term culture have been traditionally proposed as possible factors involved in the acquisition of chromosomal abnormalities. Investigators analyzed the chromosome constitution, the undifferentiated state and the functional pluripotency of three different mouse embryonic stem cells grown under the same culture conditions. [Sci Rep] Full Article
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E.U. Medicines Agency Relaxes Data-Sharing Rules
Academics breathed a cautious sigh of relief when the European Medicines Agency announced that it would soften controversial draft rules to open clinical trial data to public scrutiny. In particular, the agency says it will let researchers “download, save and print the trial data for academic and non-commercial research purposes.” [ScienceInsider] Editorial
Japanese Stem Cell Debacle Could Bring Down Center
Shutting down the research center at the heart of an unfolding scientific scandal may be necessary to prevent a recurrence of research misconduct, according to a report released at a press conference. A committee reviewing conduct at the RIKEN Center for Developmental Biology found lax oversight and a failure on the part of senior authors of two papers in Nature outlining a surprisingly simple way of reprogramming mature cells into stem cells. [ScienceInsider] Editorial
U.S. Senate Bill Would Give NIH 2% Raise in 2015
A U.S. Senate spending panel approved a draft bill that would raise the National Institutes of Health’s (NIH’s) budget by $605.7 million, to $30.5 billion, in the 2015 fiscal year. [ScienceInsider] Editorial
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