Cell Reprogramming into the Pluripotent State Using Graphene Based Substrates
The authors report that graphene promotes the reprogramming of mouse somatic fibroblasts into induced pluripotent stem cells. They found that the graphene substrate significantly improved cellular reprogramming efficiency by inducing mesenchymal-to-epithelial-transition which is known to affect H3K4me3 levels. [Biomaterials]
Abstract
Rad51 Regulates Cell Cycle Progression by Preserving G2/M Transition in Mouse Embryonic Stem Cells
Rad51 and homologous recombination accessory factors may facilitate replication fork progression by preventing replication fork collapse and repair double-strand breaks that spontaneously arise during the normal cell cycle. Researchers demonstrate a novel role for Rad51 during the cell cycle in mouse embryonic stem cells. [Stem Cells Dev]
Abstract
European Neuroscientists Revolt against the E.U.’s Human Brain Project
An influential group of European neuroscientists is threatening to boycott the Human Brain Project, the hugely ambitious plan to map the entire human brain in computer models that is slated to receive up to €1 billion in funding from the European Union and its member countries. An open letter that has so far received 213 signatures sharply criticizes the project for having a narrow focus, questions the “quality of the governance,” and calls for a tough review and more independent oversight. [ScienceInsider]
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