Genetic Insulin Resistance Is a Potent Regulator of Gene Expression and Proliferation in Human iPS Cells
To define the consequences of genetic insulin resistance distinct from those secondary to cellular differentiation or in vivo regulation, researchers generated induced pluripotent stem cells (iPSC) from individuals with insulin receptor mutations and age-appropriate controls, and studied insulin signaling and gene expression in comparison to fibroblasts from which they were derived. [Diabetes] Abstract|Press Release
Investigating Human Disease Using Stem Cell Models
Although proof of principle for the use of adult stem cells and embryonic stem cells in disease modelling has been established, induced pluripotent stem cells (iPSCs) have demonstrated the greatest utility for modelling human diseases. Furthermore, combining gene editing with iPSCs enables the generation of models of genetically complex disorders. [Nat Rev Genet] Abstract
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Three Win Inaugural Blavatnik Prizes
Adam Cohen is one of three researchers to win the inaugural Blavatnik Awards for Young Scientists, which seek to recognize America’s “most innovative young faculty-rank scientists and engineers” under the age of 43. [ScienceInsider] Editorial
Scripps President Resigns after Faculty Revolt
The president of the Scripps Research Institute intends to leave his post, according to a statement from Richard Gephardt, the chair of the institute’s board of trustees. [Nature News] Editorial
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