Volume 9.30 | Aug 6

ESC & iPSC News 9.30 August 6, 2014
ESC & iPSC News
     In this issue: Publications | Reviews | Industry News | Policy News | Events | Jobs
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TOP STORY
An Embryonic Cell’s Fate Is Sealed by the Speed of a Signal
New research suggests the speed at which a cell in an embryo receives that signal has an unexpected influence on that cell’s fate. Until now, only concentration of the chemical signals was thought to matter in determining if the cell would become, for example, muscle, skin, brain or bone. [Press release from The Rockefeller University discussing online prepublication in Developmental Cell] Press Release | Abstract
New TeSR™-E8™ is Here For Feeder-Free Culture of Human ES Cells and iPS Cells
 
PUBLICATIONS (Ranked by impact factor of the journal)
Effect of Human Donor Cell Source on Differentiation and Function of Cardiac Induced Pluripotent Stem Cells
Investigators assessed the effect of epigenetic memory on differentiation and function of induced pluripotent stem cell-cardiomyocytes generated from somatic cell sources of cardiac versus noncardiac origins. [J Am Coll Cardiol] Abstract | Press Release

Genome Editing of Isogenic Human Induced Pluripotent Stem Cells Recapitulates Long QT Phenotype for Drug Testing
Investigators sought to establish an efficient technology to generate human pluripotent stem cell-based disease models with isogenic control. [J Am Coll Cardiol] Abstract | Editorial

Seamless Gene Correction of β-Thalassemia Mutations in Patient-Specific iPSCs Using CRISPR/Cas9 and piggyBac
Researches used the latest gene-editing tool, CRISPR/Cas9 technology, combined with the piggyBac transposon to efficiently correct the human hemoglobin beta mutations in patient-derived induced pluripotent stem cells (iPSCs) without leaving any residual footprint. [Genome Res] Abstract | Press Release

P120-Catenin Regulates REST/CoREST, and Modulates Mouse Embryonic Stem Cell Differentiation
Using mouse embryonic stem cells, mammalian cell lines, Xenopus embryos, and in vitro systems, scientists found that p120 directly binds REST/CoREST, displacing the complex from established gene-targets to permit their transcriptional activation. [J Cell Sci] Abstract

WNT3A Promotes Myogenesis of Human Embryonic Stem Cells and Enhances In Vivo Engraftment
Scientists describe the use of WNT3A protein to promote in vitro myogenic commitment of human embryonic stem cells-derived cells and their subsequent in vivo function. In vivo transplantation of these committed cells into cardiotoxin-injured skeletal muscles of NOD/SCID mice reveals survival and engraftment of the donor cells. [Sci Rep] Full Article

MicroRNA-221 Is Required for Proliferation of Mouse Embryonic Stem Cells via P57 Targeting
MicroRNA-221 (miR-221) inhibitor decreased proliferation of embryonic stem (ES) cells without inducing apoptosis and necrosis. miR-221 mimic, miR-222 mimic and miR-222 inhibitor did not affect ES cells proliferation. [Stem Cell Rev] Abstract

Nonviral Minicircle Generation of Induced Pluripotent Stem Cells Compatible with Production of Chimeric Chickens
Scientists generated chicken induced pluripotent stem cells (ciPSCs) from fibroblast cells for the first time using a nonviral minicircle reprogramming approach. ciPSCs demonstrated stem cell morphology and expressed key stem cell markers, including alkaline phosphatase, POU5F1, SOX2, NANOG, and SSEA-1. [Cell Reprogram] Abstract

Generation of Induced Pluripotent Stem Cells from Hair Follicle Bulge Neural Crest Stem Cells
Although the authors confirmed the expression of pluripotency genes in hair follicle bulge cells, their results show that these cells do require a full set of reprogramming factors for induced pluripotent stem cell induction. [Cell Reprogram] Abstract

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REVIEWS
A Practical Guide to Induced Pluripotent Stem Cell Research Using Patient Samples
The authors summarize the areas where patient induced pluripotent stem cell studies have provided truly valuable information beyond existing skepticism, discuss the desired technologies to overcome current limitations and include practical guidance for how to utilize the resources. [Lab Invest] Full Article

Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field.

Fraunhofer Life Science Symposium
 
INDUSTRY NEWS
UAlbany Biologist Receives $1.43 Million NIH Award for Germline Research to Find Therapies for Cancer and Degenerative Diseases
University at Albany biologist Prashanth Rangan has received a $1.43 million grant from the National Institutes of Health (NIH) for his research into both preventing and inducing differentiation in stem cells in order to treat cancers and degenerative diseases. [University at Albany] Press Release

GeoVax Announces Clinical Development License Agreement with Valneva SE
GeoVax Labs, Inc. announced that it has signed a clinical development license agreement with Valneva SE, to develop MVA-based vaccines in Valneva’s EB66® vaccine production cell line. The EB66® cell line is derived from duck embryonic stem cells and today represents a compelling alternative to the use of chicken eggs for large scale manufacturing of human and veterinary vaccines. [GeoVax Labs, Inc.] Press Release

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POLICY NEWS
Senior RIKEN Scientist Involved in Stem Cell Scandal Commits Suicide
Yoshiki Sasai, a noted stem cell scientist at the RIKEN Center for Developmental Biology, who co-authored two controversial and later retracted papers that reported a simple way of reprogramming mature cells, was confirmed dead in an apparent suicide. [ScienceInsider] Editorial

Spain Needs ‘Major Cultural Change’ to Do Better in Science, International Panel Says
More cash and many profound structural changes, according to a panel of European experts, is what Spain’s national science and innovation system needs to become more competitive. [ScienceInsider] Editorial

Transparency Promised for Vilified Impact Factor
The most misused metric in science is getting a makeover – although many researchers would like it to disappear altogether. Information firm Thomson Reuters said that it will become more transparent over how it calculates impact factors, an annual ranking of more than 10,900 scientific journals that it published, along with the names of 39 journals that it is barring from the list. [Nature News] Editorial
 
EVENTS
NEW Genetic Engineering of Mammalian Stem Cells
February 16-28, 2015
Cambridge, United Kingdom

Visit our events page to see a complete list of events in the ESC & iPSC community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Correction of Human Pluripotent Stem Cells Generated from Patients with Hematologic Genetic Disease (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Position – The Role of Nuclear Organization in Reprogramming the Embryonic Genome (Hubrecht Institute)

NEW PhD Studentship – Epigenetic Control of Cell Identity (Institute of Molecular Biology and Tumor Research)

Postdoctoral Fellow – Stem Cell Biology and Regenerative Medicine (Brigham & Women’s Hospital – Harvard Medical School)

Technical Account Manager (GlobalStem)

Stem Cell Research Assistant – iPSC Biology and Genome Editing (Stem Cell Theranostics)

Stem Cell Research Scientist – iPSC Reprogramming and Disease Modeling (Stem Cell Theranostics)

Postdoctoral Fellow – Proteomic Analysis of the Differentiation of Human ESCs or iPSCs (Cornell University)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Human Pluripotent Stem Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)


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