Human Embryonic Stem Cells Show Low-Grade Microsatellite Instability
Given the parallels between cancer and stem cell biology, researchers investigated the occurrence of a common form of genome instability in tumors, namely microsatellite instability, in human embryonic stem cells. [Mol Hum Reprod] Abstract
A Simple and Efficient Method for Transfecting Mouse Embryonic Stem Cells Using Polyethylenimine
The authors describe conditions that permit for the efficient transfection of mouse embryonic stem cells (ESCs) with low cytotoxicity and without the need for specialized equipment. Their goal was to devise a protocol for the polyethylenimine-mediated transfection of mouse ESCs that was comparable in ease to commercial transfection reagents. [Exp Cell Res] Abstract
DLK1-DIO3 Imprinted Cluster in Induced Pluripotency: Landscape in the Mist
To date there is no marker established able to distinguish embryonic stem cell-equivalent induced pluripotent cells (iPSCs) or safe human iPSCs. Recent findings suggest that the DLK1-DIO3 locus possesses the potential to represent such a marker but there are also contradictory data. The authors report the current data on the topic describing both sides of the coin. [Cell Mol Life Sci] Abstract
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INDUSTRY NEWS
Joel Blanchard Receives Stem Cell Research Poster Award
Joel Blanchard received the 2014 Betty Jean Ogawa Memorial Poster Award at the annual meeting of the International Society for Stem Cell Research. Blanchard’s poster was titled “Deprogramming, Reprogramming: Uncovering Mechanisms and Inducers of Pluripotency via Combinatorial Antibody Screening.” [The Scripps Research Institute] Press Release
Cesca Therapeutics and Fortis Healthcare Announce Master Collaboration Agreement
Cesca Therapeutics and Fortis Healthcare Limited announced a master collaboration agreement that extends their important existing relationship. The agreement affirms Cesca’s cellular therapy and cord blood bank at the Fortis Hospital Memorial Research Institute, renews the cord blood banking collaboration and launches the stem cell therapy services for hematological diseases across the Fortis network. [Cesca Therapeutics Inc.] Press Release
Student May Be Jailed for Posting Scientist’s Thesis on Web
A Colombian biology student is facing up to eight years in jail and a fine for sharing a thesis by another scientist on a social network. Diego Gómez Hoyos posted the 2006 work, about amphibian taxonomy, on Scribd in 2011. But two years later, in 2013, he was notified that the author of the thesis was suing him for violating copyright laws. [Nature News] Editorial
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