Volume 9.33 | Aug 27

ESC & iPSC News 9.33 August 27, 2014
ESC & iPSC News
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Biologists Reprogram Skin Cells to Mimic Rare Disease
Stem cell biologists have found a way to reprogram a patient’s skin cells into cells that mimic and display many biological features of a rare genetic disorder called familial dysautonomia. The process requires growing the skin cells in a bath of proteins and chemical additives while turning on a gene to produce neural crest cells, which give rise to several adult cell types. [Press release from The Johns Hopkins University discussing prepublication in Cell Stem Cell] Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
An Organized and Functional Thymus Generated from ​FOXN1-Reprogrammed Fibroblasts
Scientists show that enforced ​forkhead box N1 (Foxn1) expression is sufficient to reprogram fibroblasts into functional thymic epithelial cells, an unrelated cell type across a germ-layer boundary. [Nat Cell Biol]
Abstract | Press Release | Video

SIRT1-Mediated Deacetylation of CRABPII Regulates Cellular Retinoic Acid Signaling and Modulates Embryonic Stem Cell Differentiation
Researchers demonstrate that SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase, contributes to homeostatic retinoic acid signaling and modulates mouse embryonic stem cell differentiation in part through deacetylation of cellular retinoic acid binding protein II (CRABPII). [Mol Cell]
Abstract | Graphical Abstract

Blocking Autocrine VEGF Signaling by Sunitinib, an Anti-Cancer Drug, Promotes Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming
Scientists found that even in medium supplemented with leukemia inhibitory factor, mouse embryonic stem cells still tend to differentiate toward meso-endoderm lineages after long-term culture and the culture spontaneously secretes vascular endothelial growth factors (VEGFs). [Cell Res] Full Article

BRD4 Regulates Nanog Expression in Mouse Embryonic Stem Cells and Preimplantation Embryos
Researchers report that bromodomain-containing protein 4 (BRD4) regulates expression of the pluripotency factor Nanog in mouse embryonic stem cells (ESCs) and preimplantation embryos, as well as in human ESCs and embryonic cancer stem cells. [Cell Death Differ] Abstract

Regulation of Mitochondrial Function and Cellular Energy Metabolism by Protein Kinase C-λ/τ: A Novel Mode of Balancing Pluripotency
Using murine embryonic stem cells (ESCs) as a model system, scientists demonstrate that atypical protein kinase C isoform, PKC lambda/iota, is a key regulator of mitochondrial function in ESCs. [Stem Cells] Abstract

Enhanced Lung Epithelial Specification of Human Induced Pluripotent Stem Cells on Decellularized Lung Matrix
Investigators evaluated the capacity of acellular lung scaffolds to support recellularization with lung progenitors derived from human induced pluripotent stem cells. [Ann Thorac Surg] Abstract

Medaka Oct4 is Essential for Pluripotency in Blastula Formation and ES Cell Derivation
Researchers report that Oloct4, the medaka oct4/pou2, is essential for early embryogenesis and pluripotency maintenance. Oloct4 exists as a single copy gene and is orthologous to pou2 by sequence and chromosome synteny. [Stem Cell Rev] Abstract

Oxygen Modulates Human Embryonic Stem Cell Metabolism in the Absence of Changes in Self-Renewal
Investigators aimed to identify physiological markers that could be used to evaluate the metabolic impact of oxygen on the MEL-2 human embryonic stem cell line after adaptation to either 5% or 20% oxygen in extended culture. [Reprod Fertil Dev] Abstract

Free Cell Stem Cell Poster: Directed Differentiation of ESCs/iPSCs
Induced Pluripotent Stem Cells for Disease Modeling and Drug Discovery in Neurodegenerative Diseases
The authors introduce induced pluripotent stem cell (iPSC)-based disease modeling in neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis. In addition, they discuss the implementation of iPSCs in drug discovery associated with some new techniques. [Mol Neurobiol] Abstract

Cellular Reprogramming by Transcription Factor Engineering
There is a growing interest in engineering novel chimeric reprogramming factors and applying designer transcription factors technology to improve reprogramming efficiency and dissect the process of endogenous pluripotency network reactivation. The authors provide a concise review on the latest progress in studying cellular reprogramming by transcription factor engineering. [Curr Opin Genet Dev] Abstract

MicroRNA-Based System in Stem Cell Reprogramming; Differentiation/Dedifferentiation
This review aims to provide state-of-the-art presentations on microRNA-dependent molecular mechanisms contribute to the maintenance of pluripotency. Understanding the microRNA signature interactions, in conjunction with cell signaling, is critical for development of improved strategies to reprogram differentiated cells or direct differentiation of pluripotent cells. [Int J Biochem Cell Biol] Abstract

Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field.

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BARDA Executes Contract Option with Cytori for Continued Development of Thermal Burn Injury Counter Measure
Cytori Therapeutics and Biomedical Advanced Research and Development Authority (BARDA) announced the execution of a contract option to fund the continued investigation and development of Cytori Cell Therapy for use in thermal burn injuries. [Cytori Therapeutics Inc.] Press Release

Penn Medicine Opens Center for Advanced Retinal and Ocular Therapeutics (CAROT)
The Perelman School of Medicine at the University of Pennsylvania has launched the CAROT to build on its previous success developing novel therapies for the personalized diagnosis and treatment of retinal and ocular disorders. [University of Pennsylvania] Press Release

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In Japan, Official Effort to Replicate STAP Stem Cells Comes Up Empty
A team of researchers at the RIKEN Center for Developmental Biology (CDB) reported that they have been unable to reproduce a simple method of creating stem cells that was reported in two Nature papers by CDB scientists earlier this year. [ScienceInsider] Editorial

Iranian Parliament Ousts Reform-Minded Science Minister
A monthslong effort to breathe new life into Iranian universities is at a crossroads after the ouster of the nation’s reformist science minister, Reza Faraji-Dana. [ScienceInsider] Editorial
NEW New York Stem Cell Foundation (NYSCF) 9th Annual Translational Stem Cell Research Conference
October 23-25, 2014
New York City, United States

Visit our events page to see a complete list of events in the ESC & iPSC community.
NEW Postdoctoral Fellow – Cardiac Differentiation of Pluripotent Stem Cells (Stanford University)

NEW Postdoctoral Fellow – Cardiac Animal Surgery (Stanford University)

Postdoctoral Research Fellow – Induced Pluripotent Stem Cell Based Therapeutics (Fred Hutchinson Cancer Research Center)

Postdoctoral Positions – Hematopoietic and Induced Pluripotent Stem Cells (Indiana University School of Medicine)

Research Technician – Maintenance of Embryonic Stem Cell Lines, Electroporation and Subcloning (Icahn School of Medicine at Mount Sinai)

Postdoctoral Research Fellow – Correction of Human Pluripotent Stem Cells Generated from Patients with Hematologic Genetic Disease (Fred Hutchinson Cancer Research Center)

Postdoctoral Position – The Role of Nuclear Organization in Reprogramming the Embryonic Genome (Hubrecht Institute)

Postdoctoral Fellow – Stem Cell Biology and Regenerative Medicine (Brigham & Women’s Hospital – Harvard Medical School)

Technical Account Manager (GlobalStem)

Stem Cell Research Assistant – iPSC Biology and Genome Editing (Stem Cell Theranostics)

Stem Cell Research Scientist – iPSC Reprogramming and Disease Modeling (Stem Cell Theranostics)

Postdoctoral Fellow – Proteomic Analysis of the Differentiation of Human ESCs or iPSCs (Cornell University)

Scientist – Pluripotent Stem Cell Biology Endoderm Lineages (STEMCELL Technologies Inc.)

Scientist – Human Pluripotent Stem Cell Biology (STEMCELL Technologies Inc.)

Scientist – Pluripotent Stem Cell Media Development, High Throughput Screening (STEMCELL Technologies Inc.)

Scientist – Cell Culture Support Products (STEMCELL Technologies Inc.)

Scientist – Immunology/Cell Separation (STEMCELL Technologies Inc.)

Research Associate – Cell Separation (STEMCELL Technologies Inc.)

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