Researchers Use iPS Cells to Show Statin Effects on Diseased Bone
The need for new drug compounds that can combat skeletal dysplasia has researchers at Kyoto University to consider induced pluripotent stem cell (iPSC) technology. They screened molecules based on their ability to rescue thanatophoric dysplasia (TD)-iPSCs from degraded cartilage. Statins were identified as good candidates and investigated because they have anabolic and protective effects on chondrocytes. [Press release from Kyoto University discussing online prepublication in the Nature] Press
Release|Abstract
Multi-Layered Global Gene Regulation in Mouse Embryonic Stem Cells
The authors summarize recent findings on global gene regulatory modes in embryonic stem cells, mainly focusing on the regulatory factors responsible for transcriptional and epigenetic regulations as well as their modular regulatory patterns throughout the genome. [Cell Mol Life Sci] Full Article
Induced Pluripotent Stem Cells from ALS Patients for Disease Modeling
The authors review the numerous challenges that remain before induced pluripotent stem cell methodologies can fulfill their potential as tools for modeling amyotrophic lateral sclerosis (ALS) as well as providing a platform for the investigation of ALS therapeutics. [Brain Res] Abstract
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INDUSTRY NEWS
Mayo Clinic and NUI Galway Formalize Collaboration
The National University Ireland (NUI) Galway has signed an agreement to formalize collaborative ties with the Mayo Clinic Center for Regenerative Medicine. The agreement follows many years of close cooperation, and paves the way for joint collaborations in clinical trials using regenerative therapies. [National University of Ireland, Galway] Press Release
Cynata Announces Landmark Licensing Deal
Cynata Therapeutics Ltd announced that it has entered into a license agreement with Cellular Dynamics International (CDI). The agreement provides Cynata with nonexclusive worldwide rights to a clinical grade human induced pluripotent stem cell line manufactured by CDI. [Cynata Therapeutics Ltd.] Press Release
Stem Cell Tourism and Patient Education
“Stem cell tourism” is a term used to describe an Internet-based, direct-to-consumer advertised industry where patients receive unproven stem cell-based interventions (SCBIs) for a range of diseases and injuries. Many clinics offering unproven SCBIs are in countries with lax regulations and enforcement. However, these clinics are also increasingly popping up in highly regulated countries like the U.S., U.K. and Australia. [Knoepfler Lab Blog] Editorial
Nature Communications to Become Open Access Only Nature Communications is to become the first Nature-branded open access only journal. Nature Communications will only accept open access research submissions from 20th October 2014. [Nature] Press Release
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