Volume 15.24 | June 24

2020-06-24 | ESC 15.24
ESC & iPSC News by STEMCELL Technologies
Vol. 15.24 – 24 June, 2020

Epigenetic Priming by Dppa2 and 4 in Pluripotency Facilitates Multi-Lineage Commitment

Differentiation assays revealed that developmental pluripotency associated 2 and 4 (Dppa2/4) double knockout mouse ESCs failed to exit pluripotency and differentiate efficiently.
[Nature Structural & Molecular Biology]


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BRPF3-HUWE1-Mediated Regulation of MYST2 Is Required for Differentiation and Cell-Cycle Progression in Embryonic Stem Cells

Researchers provided novel insights into understanding the functions of Brpf3 in proper differentiation as well as cell-cycle progression of ESCs via regulation of Myst2 stability by obstructing Huwe1-mediated ubiquitination.
[Cell Death & Differentiation]

Full Article

In Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment

Scientists generated human iPSC-derived neurons exhibiting spontaneous oscillatory activity after cultivation of up to six months, which resembled early oscillations observed in rodent neurons. This behavior was found in neurons generated using a more “native” embryoid body protocol, in contrast to a “fast” protocol based on NGN2 overexpression.
[Stem Cell Reports]

Full ArticleGraphical Abstract

The Chromatin Regulator ZMYM2 Restricts Human Pluripotent Stem Cell Growth and is Essential for Teratoma Formation

The authors examined the effect of mutations in 703 genes from nearly 70 chromatin-modifying complexes on human ESC growth. While the vast majority of chromatin-associated complexes were essential for ESC growth, the only complexes that conferred growth advantage upon mutation of their members, were the repressive complexes LSD-CoREST and BHC.
[Stem Cell Reports]

Full ArticleGraphical Abstract

Cortical Neurons Derived from Human Pluripotent Stem Cells Lacking FMRP Display Altered Spontaneous Firing Patterns

Electrophysiological whole-cell voltage- and current-clamp recordings were performed on two control and three fragile X syndrome patient lines of human cortical neurons derived from iPSCs.
[Molecular Autism]

Full Article

Novel Venom-Based Peptides (P13 and Its Derivative—M6) to Maintain Self-Renewal of Human Embryonic Stem Cells by Activating FGF and TGFβ Signaling Pathways

Investigators provided the first research finding on a venom-based peptide that works on the FGF and TGF-β signaling pathways to maintain the self-renewal of human ESCs.
[Stem Cell Research & Therapy]

Full Article

Signaling Inhibitors Accelerate the Conversion of Mouse iPS Cells into Cancer Stem Cells in the Tumor Microenvironment

Inhibition of Erk1/2, tyrosine kinase, and/or GSK-3β was implied to be involved in the enhancement of the PI3K-AKT signaling pathway in the undifferentiated cells, resulting in the sustained stemness, and subsequent conversion of mouse iPSCs into cancer stem cells in the tumor microenvironment.
[Scientific Reports]

Full Article

Derivation of Oocyte-Like Cells from Putative Embryonic Stem Cells and Parthenogenetically Activated into Blastocysts in Goat

Scientists demonstrated that goat putative ESCs were successfully in vitro differentiated into primordial germ cells and oocyte-like cells using bone morphogenetic protein-4 and trans-retinoic acid.
[Scientific Reports]

Full Article

AAV-Mediated FOXG1 Gene Editing in Human Rett Primary Cells

Investigators demonstrated that an adeno-associated viruses-coupled CRISPR/Cas9 system was able to target and correct Forkhead Box G1 (FOXG1) variants in patient-derived fibroblasts, iPSCs and iPSC-derived neurons.
[European Journal of Human Genetics]


A Simple, Quick, and Efficient CRISPR/Cas9 Genome Editing Method for Human Induced Pluripotent Stem Cells

The authors report an electroporation-mediated plasmid CRISPR/Cas9 delivery approach for genome editing in iPSCs. With this approach, an edited iPSC cell line could be obtained within two weeks.
[Acta Pharmacologica Sinica]


A lncRNA-miRNA-mRNA Network for Human Primed, Naive and Extended Pluripotent Stem Cells

Researchers successfully converted three in-house-derived primed human PSC lines (H10, H24, and iPS) to a naive state and an expanded PSC (EPS) state. Primed, naive and EPS cells displayed state-specific morphologies and expressed pluripotent markers.
[PLoS One]

Full Article

Virtual Conference Exhibition: Pluripotent Stem Cells

Genome Engineering of Induced Pluripotent Stem Cells to Manufacture Natural Killer Cell Therapies

The authors highlight the current sources for natural killer (NK) therapies and their respective constraints, discuss recent developments in the manufacturing and genetic engineering of iPSC-NK cells, and provide an overview of ongoing clinical trials using NK cells.
[Stem Cell Research & Therapy]

Full Article


Century Therapeutics Announces Acquisition of Empirica Therapeutics

Century Therapeutics has announced its acquisition of Empirica Therapeutics to leverage its iPSC-derived allogeneic cell therapies against glioblastoma.
[Businesswire (Century Therapeutics)]

Press Release

Trump to Suspend New Visas for Foreign Scholars

With a proclamation issued on Monday, US President Donald Trump extended and expanded immigration restrictions to limit the entry of foreign workers to the United States. The move set off ripples of alarm among scientists and drew fire from experts concerned about the future of US science.
[Nature News]



Micro-CT: Fancy Gadget or Indispensable Technology towards Accurate Quantification of Lung Disease and Therapy?

2020-07-09 – 2020-07-09

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Postdoctoral Research Scientist – Stem Cell Biology

The Babraham Institute – Cambridge, United Kingdom

Postdoctoral Fellow – Pluripotent Stem Cell Biology

Northwestern University – Chicago, Illinois, United States

Assistant Professor – Pluripotent Stem Cell Biology

Sup’Biotech Engineering School – Villejuif, Lyon, France

Postdoctoral Fellow – Human Induced Pluripotent Stem Cell-Derived T Cell Process Development

Genentech – South San Francisco, California, United States

Postdoctoral Fellow – Neuroinflammation

Henry Ford Health System – Detroit, Michigan, United States

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