Autophagy and mTORC1 Regulate the Stochastic Phase of Somatic Cell Reprogramming
Scientists described robust induction of autophagy during the reprogramming of mouse fibroblasts to induced pluripotent stem cells by four reprogramming factors (Sox2, Oct4, Klf4 and c-Myc). This process occured independently of p53 activation, and was mediated by the synergistic downregulation of mechanistic target of rapamycin complex 1 (mTORC1) and the induction of autophagy-related genes. [Nat Cell Biol] Abstract
US Science Academies Take on Human-Genome Editing
The United States National Academy of Sciences and the National Academy of Medicine will launch a major initiative to develop guidelines for editing human genomes. [Nature News] Editorial
Steve Campana, Canadian Biologist, ‘Disgusted’ with Government Muzzling
A recently retired Fisheries and Oceans Canada biologist says the muzzling of federal government scientists is worse than anyone can imagine. Steve Campana, known for his expertise on everything from great white sharks to porbeagles and Arctic trout, says the atmosphere working for the federal government is toxic. [Canadian Broadcasting Corporation] Editorial
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