Barriers for Deriving Transgene-Free Pig iPS Cells with Episomal Vectors
The authors generated porcine induced pluripotent stem cells (iPSCs) using non-integrating replicating episomal plasmids. Although these porcine iPSCs met most pluripotency criteria, they could neither generate cloned piglets through nuclear transfer, nor contribute to later stage chimeras through morula injections or aggregations. [Stem Cells] Abstract
MiR-181c Regulates Human Embryonic Stem Cell Differentiation via Targeting GATA4
Investigators provided evidence that miR-181c was significantly increased in undifferentiated human embryonic stem cells (hESCs) and decreased in differentiated cells. In addition, knockdown of miR-181c down-regulated the expression of hESC pluripotency markers Oct4, Sox2, Nanog and c-Myc. [Mol Cells] Abstract
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INDUSTRY NEWS
CSU Awarded $1.3 Million NIH Grant for Stem Cell Research
Moo-Yeal Lee, Ph.D., and Chandra Kothapalli, Ph.D., of Cleveland State University have been awarded a $1.3 million grant from the National Institutes of Health for innovative stem cell research to improve testing for toxic compounds that could harm the development of the human brain. [Cleveland State University] Press Release
Russia’s Only Private Science Funder Closes Its Doors
The Dynasty Foundation, Russia’s only private funder of scientific research, announced its closure after being labeled a “foreign agent” by the Russian government in May. The decision was made at a meeting of the foundation’s council and published on Dynasty’s website. [ScienceInsider] Editorial
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