Volume 10.44 | Nov 25

ESC & iPSC News 10.44 November 25, 2015
ESC & iPSC News
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Ancient Viral Molecules Essential for Human Development
Scientists have shown that certain noncoding RNA molecules, which are genetic remnants of an ancient virus, play a critical role in balancing decisions in early human development–namely pluripotency of early stem cells, a genetic state that enables them to modulate the gamut of human developmental decisions and timing. [Press release from Montana State University discussing online prepublication in Nature Genetics]
Press Release | Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
The Metabolome Regulates the Epigenetic Landscape during Naive-to-Primed Human Embryonic Stem Cell Transition
Researchers showed that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in human embryonic stem cells (hESCs). In naive hESCs, NNMT and its enzymatic product 1-methylnicotinamide are highly upregulated, and NNMT is required for low S-adenosyl methionine levels and the H3K27me3 repressive state. [Nat Cell Biol] Abstract

Parthenogenetic Haploid Embryonic Stem Cells Efficiently Support Mouse Generation by Oocyte Injection
The authors showed that parthenogenetic (PG)-haploid embryonic stem cells (haESCs) exhibit highly similar gene expression profiles to those of androgenetic-haESCs, and after removal of H19 and Gtl2 differentially methylated DNA regions, DKO-PG-haESCs can efficiently produce semi-cloned pups. [Cell Res] Full Article

Combining Suppression of Stemness with Lineage-Specific Induction Leads to Conversion of Pluripotent Cells into Functional Neurons
The authors describe a strategy that relies on a combination of Sox2 inhibition with lineage-specific induction to promote efficient and selective differentiation of pluripotent P19 cells into neurons. [Chem Biol]
Abstract | Graphical Abstract

Selection and Dynamics of Embryonic Stem Cell Integration into Early Mouse Embryos
The process by which pluripotent cells incorporate into host embryos is of interest to investigate cell potency and cell fate decisions. By comparing a heterogeneous mix of undifferentiated and differentiating embryonic stem cell with more homogeneous undifferentiated culture, the authors examined the role of cellular heterogeneity in this process. [Development] Abstract | Full Article

The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells
Investigators describe a system for efficiently guiding human embryonic stem cells into nociceptive neurons by first inducing these cells to the neural lineage. [Sci Rep] Full Article

Wnt/β-Catenin and LIF/Stat3 Signaling Pathways Converge on Sp5 to Promote Mouse Embryonic Stem Cell Self-Renewal
Researchers found that the leukemia inhibitor factor (LIF)/Stat3 and Wnt/β-catenin signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal. [J Cell Sci] Abstract | Full Article

Regulation of C-Myc Expression by Ahnak Promotes iPSC Generation
The authors showed that inhibition of Ahnak can promote generation of induced pluripotent stem cells (iPSC) via up-regulation of endogenous c-Myc. [J Biol Chem] Abstract | Full Article

Recombinant Xeno-Free Vitronectin Supports Self-Renewal and Pluripotency in Protein Induced Pluripotent Stem Cells
Investigators tested whether recombinant human matrix proteins can support self-renewal and pluripotency of protein-induced pluripotent stem cells (piPSCs). After long term culture on recombinant human vitronectin in xeno-free conditions, piPSCs retained the expression of pluripotent markers. [Tissue Eng Part C Methods] Abstract

Generation of Airway Epithelial Cells with Native Characteristics from Mouse Induced Pluripotent Stem Cells
Scientists generated airway epithelial cells from embryoid bodies by culturing them under serum-free conditions supplemented with Activin and bFGF and by the air-liquid interface method and characterized the induced pluripotent stem cell-derived airway epithelial cells in terms of their gene expression, immunoreactivity, morphology, and function. [Cell Tissue Res] Abstract

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Using hiPSCs to Model Neuropsychiatric Copy Number Variations (CNVs) Has Potential to Reveal Underlying Disease Mechanisms
Genetically engineered mouse models can recapitulate rare variants, displaying some behavioral defects associated with schizophrenia; however, these mouse models cannot recapitulate the full genetic architecture underlying the disorder. Patient-derived human induced pluripotent stem cells (hiPSCs) present an alternative approach for studying rare variants, in the context of all other risk alleles. [Brain Res] Abstract

Back and Forth in Time: Directing Age in iPSC-Derived Lineages
Following significant progress in manipulating cellular fate, the stem cell field will now have to face the new challenge of controlling cellular age, in order to fully harness the potential of induced pluripotent stem cell (iPSC)-technology to advance the research and cure of diseases of the aging brain. [Brain Res] Abstract

Visit our reviews page to see a complete list of reviews in the ESC & iPSC research field.

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Nova Southeastern University Announces New NSU Cell Therapy Institute, an International Biomedical Research Collaboration with Scientists from the World-Renowned Karolinska Institutet
Nova Southeastern University (NSU) is at the forefront of conducting pioneering cell-based biomedical research with the launch of the new NSU Cell Therapy Institute, an international collaboration with prominent medical research scientists from Karolinska Institutet. [Nova Southeastern University (PR Newswire Association LLC)] Press Release

Two MD Anderson Faculty Named as Prestigious AAAS Fellows
Distinguished contributions to understanding p53 tumor suppression in stem cells and breakthrough advances in treating breast cancer have earned two scientists at The University of Texas MD Anderson Cancer Center membership in a notable association of scholars. [The University of Texas MD Anderson Cancer Center] Press Release

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China Pursues Fraudsters in Science Publishing
China’s main basic research agency is cracking down on scientists who used fake peer reviews to publish papers, demanding that serious offenders return research funding. [ScienceInsider] Editorial

UK Scientists Celebrate Slight Rise in Research Budget
UK scientists’ worst funding fears have not come to pass. The country’s science budget will increase slightly in the coming years, Chancellor of the Exchequer George Osborne announced as part of a much-anticipated government spending review. [Nature News] Editorial
NEW Cell Symposia – 10 Years of iPSCs
September 25-27, 2016
Berkeley, United States

Visit our events page to see a complete list of events in the ESC & iPSC community.
NEW Assistant or Associate Professor – Regenerative Kidney Research (University of Montreal)

NEW Assistant, Associate or Full Professor – Regenerative Vision Research (University of Montreal)

Team Leader/Professor/Associate Professor – Regenerative Medicine (Ji Nan University)

Postdoctoral Fellow and Research Scientist – Epigenomics and Systems Biology (Icahn School of Medicine at Mount Sinai)

Postdoctoral Fellow – Cardiac Regeneration (Duke University)

Postdoctoral Position – Modeling and Treatment of Human Skeletal Muscle Diseases (Duke University)

Team Leader Position – Developmental Biology (Institut de Biologie Paris-Seine)

Postdoctoral Position – Neuroscience/Stem Cell Research (University of California, Davis)

Postdoctoral Position – Tissue Engineering and Regenerative Medicine (Northwestern University)

Postdoctoral Fellow – iPSC Research (Icahn School of Medicine at Mount Sinai)

Postdoctoral Position – Biomaterials for Cell Reprogramming (Institute of Tissue Regeneration Engineering)

Assistant/Associate/Full Professor – Biomedical Engineering (Worcester Polytechnic Institute)

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