Volume 11.08 | Mar 2

ESC & iPSC News 11.08 March 2, 2016
ESC & iPSC News
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Scientists Create Functional Sperm from Stem Cells in Lab
Scientists created functioning sperm from mouse embryonic stem cells in the laboratory, a major scientific development that could lead to a treatment for male infertility in humans. They then successfully used the functional sperm cells to produce healthy mouse offspring, which went on to give birth to the next generation. [Press release from Chinese Academy of Sciences discussing online publication in Cell Stem Cell] Press Release | Full Article | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Establishment of Human iPSC-Based Models for the Study and Targeting of Glioma Initiating Cells
Researchers report on the use of human-induced pluripotent stem cells (hiPSCs) for modeling gliomagenesis. Dysregulation of RTK (receptor tyrosine kinase) and p53 signaling in hiPSC-derived neural progenitor cells recapitulated glioma tumor-initiating cells properties in vitro. [Nat Commun] Full Article

Yap1 Is Dispensable for Self‐Renewal but Required for Proper Differentiation of Mouse Embryonic Stem (ES) Cells
The authors report that Yap1 plays crucial roles in normal differentiation rather than self‐renewal of ES cells. Yap1‐depleted ES cells maintain an undifferentiated state with a typical colony morphology as well as robust alkaline phosphatase activity. [EMBO J] Abstract | Graphical Abstract 

Effects of Genetic Correction on the Differentiation of Hair Cell-Like Cells from iPSCs with MYO15A Mutation
Scientists report the generation of induced pluripotent stem cell (iPSCs) from members of a Chinese family carrying MYO15A c.4642G>A and c.8374G>A mutations and the induction of hair cell-like cells from those iPSCs. The compound heterozygous MYO15A mutations resulted in abnormal morphology and dysfunction of the derived hair cell-like cells. [Cell Death Differ] Abstract

Inhibition of FAK Signaling by Integrin α6β1 Supports Human Pluripotent Stem Cell Self-Renewal
Researchers describe a signaling pathway in human pluripotent stem cells linking self-renewal and expression of pluripotency transcription factors to integrin α6β1 and inactivation of focal adhesion kinase (FAK). [Stem Cells] Abstract

Epigenetic Silencing of the Key Antioxidant Enzyme Catalase in Karyotypically Abnormal Human Pluripotent Stem Cells
Investigators explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. [Sci Rep] Full Article

A Non-Invasive Method to Determine the Pluripotent Status of Stem Cells by Culture Medium MicroRNA Expression Detection
Investigators present a new method to non-destructively determine the pluripotent level of embryonic stem cells and induced pluripotent stem cells, or the types of differentiated cells. [Sci Rep] Full Article

Conditional Mutation of Smc5 in Mouse Embryonic Stem Cells Perturbs Condensin Localization and Mitotic Progression
Using mouse embryonic stem cells with a conditional knockout allele of Smc5, scientists showed that Smc5 protein depletion resulted in destabilization of the Smc5/6 complex, accumulation of cells in G2 phase of the cell cycle and apoptosis. [J Cell Sci] Abstract

Higher-Density Culture in Human Embryonic Stem Cells Results in DNA Damage and Genome Instability
The authors demonstrated that medium acidification linked to culture density is the main cause of DNA damage and genomic alterations in human embryonic stem cells grown on feeder layers, even in the short time span of a single passage. [Stem Cell Reports] Full Article | Graphical Abstract

MiR-134-Mbd3 Axis Regulates the Induction of Pluripotency
Scientists report that the expression level of microRNA-134 (miR-134) was low in mouse embryonic stem cells but significantly up-regulated during neural differentiation, while down-regulated during the induction of induced pluripotent stem cells from neural progenitor cells. [J Cell Mol Med] Abstract

Zinc Chloride Transiently Maintains Mouse Embryonic Stem Cell Pluripotency by Activating Stat3 Signaling
Investigators showed that 2 μM zinc chloride (ZnCl2) transiently maintained mouse embryonic stem (ES) cell pluripotency in vitro. The cultured mouse ES cells remained undifferentiated under 2 μM ZnCl2 treatment in leukemia inhibitory factor withdrawal, retinoic acid or embryoid bodies differentiation assays. [PLoS One] Full Article

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Genome Editing in Pluripotent Stem Cells: Research and Therapeutic Applications
The authors provide an overview of the available genome editing systems and discuss opportunities and perspectives for their application in basic research and clinical practice, with a particular focus on human pluripotent stem cell based research and gene therapy approaches. [Biochem Biophys Res Commun] Abstract

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Xcell Biosciences to Introduce Next Generation System for Cell-Based Assays
Xcell Biosciences, Inc. announced that the company will unveil its Avatar system, a revolutionary new platform for culturing and propagating tumor samples, circulating tumor cells from liquid biopsies, stem cells and primary samples. [Press release from Xcell Biosciences, Inc (Business Wire) discussing research to be presented at the Molecular Medicine Tri-Conference, San Francisco] Press Release

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ReNeuron Gears Up to Move into Welsh Government’s New Facility
ReNeuron is gearing up to move its entire operations to the Welsh Government’s new Advanced Therapies Medicinal Products facility at Pencoed. [Welsh Government] Press Release

STC-Stem Cell Treatment & Research Institute Registers Local Patent for Method to Mass Produce Pluripotent Stem Cells without Side Effects
STC-Stem Cell Treatment & Research Institute Chairman Kye-ho Lee announced registration of a local patent on the method to mass produce its pluripotent stem cells without side effects. [STC-Stem Cell Treatment & Research Institute (PR Newswire Association LLC.)] Press Release
Indian Scientists Decry Spending Plan
Science spending in India is slated to rise 11% in the 2016–17 fiscal year to $1.19 billion, according to the budget proposal presented by the government of Prime Minister Narendra Modi. But many observers point out that inflation—projected to run at least 5% in the coming year—will consume much of the increase and that far greater investments are needed to revamp crumbling infrastructure. [ScienceInsider] Editorial

Italian Scientists Protest ‘Serious Neglect’ of Research
Fed up with their country’s politicians, Italian scientists have launched a national debate about the dire state of their country’s research system. They want the government to reverse years of budget cuts and prevent increasing numbers of researchers moving overseas for work. [ScienceInsider] Editorial
NEW 28th 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
November 29-December 2, 2016
Munich, Germany

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NEW Research Technologist – Pluripotent Stem Cell Biology (STEMCELL Technologies Inc.)

NEW Scientist – Pluripotent Stem Cells (STEMCELL Technologies Inc.)

NEW Postdoctoral Fellow – Chromatin Biology (UT Southwestern Medical Center)

Scientist – Human Pluripotent Stem Cell Neural Differentiation (STEMCELL Technologies Inc.)

Postdoctoral Position – Human Pluripotent Stem Cells, Neurodevelopmental Disorders and Neural Repair (University of Nebraksa Medical Center)

Postdoctoral Position – Stem Cell Biology and Leukemogenesis (Fundação Hemocentro de Ribeirão Preto)

Postdoctoral Positions – Immunology, Cancer, and Stem Cells (University of Connecticut)

PhD Position – Developmental Epigenetics (Institute of Molecular Biology)

Postdoctoral Positions – Human Stem Cells (University of Pittsburgh)

Research Associate – ES Cell Biology Team (Kymab Ltd)

Postdoctoral Position – Genetics and Genomics of Stem Cells (Albert Einstein College of Medicine of Yeshiva University)

Postdoctoral Fellow – Bioinformatics and Stem Cell Biology (University of Texas)

Postdoctoral Candidate – Embryonic Stem Cells and Chromatin Biology (University of Michigan)

Development Engineer/Scientist – Regenerative Medicine (Centre for Commercialization of Regenerative Medicine)

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