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ESC & iPSC News
ESC & iPSC News is an online resource dedicated to the latest research in the fields of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
Cabinet Approves Two Draft Bills on Regenerative Medicine
[Overseas Community Affairs Council, Republic of China] Executive Yuan approved the Ministry of Health and Welfare's draft bills for a regenerative medicine act and a regenerative pharmaceuticals act.
Heparan Sulfate Chain-Conjugated Laminin-E8 Fragments Advance Paraxial Mesodermal Differentiation Followed by High Myogenic Induction from hiPSCs
[Advanced Science] A system was described for differentiating hiPSCs on new generation laminin fragments, a recombinant form of a laminin E8 fragment conjugated to the heparan sulfate chains attachment domain of perlecan.
hESC- and hiPSC-Derived Schwann Cells Are Molecularly Comparable and Functionally Equivalent
[iScience] Given that the equivalence of hESCs and hiPSCs remained controversial, investigators sought to compare the molecular and functional equivalence of hESC- and hiPSC-derived Schwann cells generated with a previously reported protocol.
3D Reconstruction of a Gastrulating Human Embryo
[Cell] Scientists constructed a 3D model of the CS8 embryo, in which a range of cell subtypes were identified, based on gene expression patterns and positional register, along the anterior-posterior, medial-lateral, and dorsal-ventral axis in the embryo.
Branching Topology of the Human Embryo Transcriptome Revealed by Entropy Sort Feature Weighting
[Development] The authors showed that Entropy Sorting provided an alternative mathematical framework for feature selection. On synthetic datasets, continuous entropy sort feature weighting outperformed highly variable gene selection in distinguishing cell state specific genes.
A High Efficiency Precision Genome Editing Method with CRISPR in iPSCs
[Scientific Reports] The authors demonstrated that a combination of p53 inhibition and pro-survival small molecules achieved a homologous recombination rate higher than 90% using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) in human iPSCs.
SRRM2 Splicing Factor Modulates Cell Fate in Early Development
[Biology Open] The authors showed that serine/arginine repetitive matrix 2 (Srrm2) dosage was critical for maintaining ESC pluripotency and cell identity.
Development and Application of Haploid Embryonic Stem Cells
[Stem Cell Research & Therapy] Investigators review the progress of haploid ESC research and briefly discuss the applications of haploid ESCs.
Induced Pluripotent Stem Cells (iPSCs): Molecular Mechanisms of Induction and Applications
[Signal Transduction and Targeted Therapy] The authors outline key developments in the iPSC field and highlight the immense versatility of the iPSC technology for in vitro modeling and therapeutic applications.
YY1 Binding Is a Gene-Intrinsic Barrier to Xist-Mediated Gene Silencing
[EMBO Reports] Researchers examined mESC lines with an inducible Xist allele and integrated allele-specific data of gene silencing and decreasing inactive X chromatin accessibility over time courses of Xist induction with cellular differentiation.
Precise Editing of Pathogenic Nucleotide Repeat Expansions in iPSCs Using Paired Prime Editor
[Nucleic Acids Research] Scientists presented a precise and programmable method called prime editor–mediated correction of nucleotide repeat expansion for correcting pathogenic nucleotide repeat expansion.
Maternal Factor Trim75 Contributes to Zygotic Genome Activation Program in Mouse Early Embryos
[Molecular Biology Reports] The authors utilized published single-cell RNA sequencing data from a Dux-mediated mESCs to induce a 2-cell-like transition state and selected potential drivers for the transition according to an RNA velocity analysis.
Since 2007, ESC & iPSC News has been providing updates on the top publications, reviews, and news in pluripotent stem cell research. Through our website, Twitter, and email newsletters, our editorial team is proud to help keep researchers and medical professionals up-to-date with the latest discoveries, jobs, and event postings in the pluripotent stem cell field.
